Results 231 to 240 of about 41,551 (306)

Transcriptome assemblies for two drug‐type cannabis chemotypes by long‐read RNA sequencing

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Cannabis sativa has undergone over 10,000 years of domestication, resulting in extensive genetic and phenotypic diversity among cultivated chemotypes. Increased medical and recreational use of specialized metabolites accumulating in cannabis glandular trichomes—primarily the cannabinoids ∆9‐tetrahydrocannabinol (THC) and cannabidiol (CBD)—has ...
Oliver Berkowitz, Ricarda Jost, Sophia Ng, Antony Bacic, James Whelan, Mathew G. Lewsey   +5 more
wiley   +1 more source

Neuroprotective effects of G9a inhibition and cannabinoid receptor activation in Alzheimer's disease through a pharmacological approach. [PDF]

Neurotherapeutics
Bellver-Sanchis A, Ribalta-Vilella M, Lillo J, Ortuño-Sahagún D, Franco R, Pallàs M, Navarro G, Griñán-Ferré C.   +7 more
europepmc   +1 more source

Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Canine mammary carcinoma (CMC) is characterised by a chronic inflammatory microenvironment resembling human breast cancer; however, the upstream regulatory mechanisms driving this phenotype remain unclear. The endocannabinoid system (ECS) has emerged as a potential modulator of inflammation and tumour biology.
Gianluca Antonio Franco, Ylenia Marino, Claudia Rifici, Roberta Fusco, Davide di Paola, Salvatore Cuzzocrea, Giuseppe Catone, Cecilia Vullo, Enrico Gugliandolo   +8 more
wiley   +1 more source

In vitro CB₁ receptor activity of halogenated indazole synthetic cannabinoid receptor agonists. [PDF]

Arch Toxicol
Green H, McKenzie C, Hamra E, Rautio T, Wu X, Juneskog E, Sandblom R, Monti MC, Persson M, Norman C.   +9 more
europepmc   +1 more source

Effect of environmental temperature on oxidative status, inflammatory response and endocannabinoid system at oestrus in dairy cows

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Heat stress (HS) poses a significant challenge to dairy production under climate change, as it compromises fertility, productivity and overall health in cows. This seasonal observational cross‐sectional study investigated how environmental temperature affects oxidative status, inflammatory responses and endocannabinoid system (ECS ...
Alice Carbonari, Lorenza Frattina, Matteo Burgio, Vincenzo Cicirelli, Michal Andrzej Kosior, Alessandra Sfacteria, Bianca Gasparrini, Gabriele Marino, Roberta Verde, Fabiana Piscitelli, Annalisa Rizzo   +10 more
wiley   +1 more source

Kinin B1 receptor mediates acute cardiovascular and neural responses following cannabinoid receptor 1 activation in conscious male mice. [PDF]

Physiol Rep
Theobald D, Ahmed SA, Abdel-Rahman AA, Sriramula S.   +3 more
europepmc   +1 more source

Trends in fentanyl‐containing drug samples seized by law enforcement agencies across Canada

Addiction, Volume 121, Issue 6, Page 1530-1540, June 2026.
Abstract Background and aims Canada's drug toxicity crisis has been largely attributed to a volatile fentanyl‐dominated unregulated drug supply with increasing reports of fentanyl detected in combination with benzodiazepines, stimulants and xylazine.
Shaleesa Ledlie, Ria Garg, Pamela Leece, Gillian Kolla, Elaine Hyshka, Mina Tadrous, Tara Gomes   +6 more
wiley   +1 more source

Targeting cannabinoid receptor 1 for antagonism in pro-fibrotic alveolar macrophages mitigates pulmonary fibrosis. [PDF]

JCI Insight
Basu A, Arif M, Wolf KM, Behee M, Johnson N, Pommerolle L, Pineda RH, Sembrat J, Zawatsky CN, Dvorácskó S, Coffey NJ, Park JK, Karagoz SB, Godlewski G, Jourdan T, Harvey-White J, Königshoff M, Iyer MR, Cinar R.   +18 more
europepmc   +1 more source

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

Addiction, Volume 121, Issue 6, Page 1541-1556, June 2026.
Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu, Chia‐Chun Hung, Marc N. Potenza, Kun‐Hsien Chou, Pei‐Lin Lee, Chu‐Chung Huang, Chiang‐Shan R. Li, Tony Szu‐Hsien Lee, Ching‐Po Lin   +8 more
wiley   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source