Results 61 to 70 of about 247,999 (295)

Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus [PDF]

Brain Structure and Function, 2015
The cannabinoid type 1 receptor (Cnr1, CB1R) mediates a plethora of physiological functions in the central nervous system as a presynaptic modulator of neurotransmitter release. The recently identified cannabinoid receptor-interacting protein 1a (Cnrip1a, CRIP1a) binds to the C-terminal domain of CB1R, a region known to be important for receptor ...
Guggenhuber, S, Alpar, A, Chen, R, Schmitz, N, Wickert, M, Mattheus, T, Harasta, AE, Purrio, M, Kaiser, N, Elphick, MR, Monory, K, Kilb, W, Luhmann, HJ, Harkany, T, Lutz, B, Klugmann, M   +15 more
openaire   +4 more sources

Computational and Experimental Drug Repurposing of FDA-Approved Compounds Targeting the Cannabinoid Receptor CB1

Pharmaceuticals, 2023
The cannabinoid receptor 1 (CB1R) plays a pivotal role in regulating various physiopathological processes, thus positioning itself as a promising and sought-after therapeutic target.
Emanuele Criscuolo, Maria Laura De Sciscio, Angela De Cristofaro, Catalin Nicoara, Mauro Maccarrone, Filomena Fezza   +5 more
doaj   +1 more source

Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies. [PDF]

, 2013
Second-generation antipsychotic exposure, in both children and adults, carries significant risk for excessive weight gain that varies widely across individuals.
Aman, MG, Arnold, LE, Handen, B, Johnson, C, Lecavalier, L, McCracken, JT, McDougle, CJ, Nurmi, EL, Posey, DJ, Research Units on Pediatric Psychopharmacology Autism Network, Ritz, L, Scahill, LL, Spilman, SL, Stigler, KA, Sukhodolsky, DG, Tierney, E, Vitiello, B, Whelan, F   +17 more
core   +1 more source

Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: implications for drug discovery.

Future Medicinal Chemistry, 2019
Allosteric modulators of cannabinoid receptors hold great therapeutic potential, as they do not possess intrinsic efficacy, but instead enhance or diminish the receptor's response of orthosteric ligands allowing for the tempering of cannabinoid receptor ...
F. Gado, Serena Meini, S. Bertini, M. Digiacomo, M. Macchia, C. Manera   +5 more
semanticscholar   +1 more source

Distinct Binding Mechanisms for Allosteric Sodium Ion In Cannabinoid Receptors

bioRxiv, 2021
The therapeutical potential of Cannabinoid receptors is not fully explored due to psychoactive side-effects and lack of selectivity associated with the orthosteric ligands.
Soumajit Dutta, Balaji Selvam, D. Shukla
semanticscholar   +1 more source

Membrane cholesterol dependence of cannabinoid modulation of glycine receptor

The FASEB Journal, 2020
Abstract Cannabinoids exert therapeutic effects on several diseases such as chronic pain and startle disease by targeting glycine receptors (GlyRs). Our previous studies have shown that cannabinoids target a serine residue at position 296 in the third transmembrane helix of the α1/α3 GlyR.
Lei, Yao, Marta, Wells, Xiongwu, Wu, Yan, Xu, Li, Zhang, Wei, Xiong   +5 more
openaire   +3 more sources

Neuroinflammation—the role of heteroreceptor complexes [PDF]

Exploration of Neuroprotective Therapy
Neuroinflammation is a hallmark of various neurodegenerative and neuropsychiatric disorders, driven by complex interactions between neurotransmitter receptors and immune signaling pathways.
Neelakanta Sarvashiva Kiran, Senthilkumar Rajagopal   +1 more
doaj   +1 more source

The bridge between classical and ‘synthetic’/chemical psychoses: towards a clinical, psychopathological and therapeutic perspective [PDF]

, 2019
© 2019 Orsolini, Chiappini, Papanti, De Berardis, Corkery and Schifano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Chiappini, Stephania, Corkery, John Martin, De Berardis, Domenico, Orsolini, Laura, Papanti, Duccio, Schifano, Fabrizio   +5 more
core   +2 more sources

Brain cannabinoid CB2 receptors modulate cocaine's actions in mice [PDF]

Nature Neuroscience, 2011
The presence and function of cannabinoid CB(2) receptors in the brain have been subject to debate. We report here that systemic, intranasal or intra-accumbens local administration of JWH133, a selective CB(2) receptor agonist, dose-dependently inhibits intravenous cocaine self-administration, cocaine-enhanced locomotion, and cocaine-enhanced accumbens ...
Xi, Zheng-Xiong, Peng, Xiao-Qing, Li, Xia, Song, Rui, Zhang, Haiying, Liu, Qing-Rong, Yang, Hong-Ju, Bi, Guo-Hua, Li, Jie, Gardner, Eliot L.   +9 more
openaire   +1 more source

Cannabinoid Modulation of Memory Consolidation in Rats: Beyond the Role of Cannabinoid Receptor Subtype 1 [PDF]

Frontiers in Pharmacology, 2017
The effects induced by exogenous manipulation of endocannabinoid neurotransmission on emotion and memory are often contradictory. Among the different factors involved, of particular interest is the binding affinity of endocannabinoids, and their analogs, for other receptor families beyond cannabinoid receptors, such as the peroxisome proliferator ...
RATANO, PATRIZIA, PALMERY, Maura, Trezza, Viviana, CAMPOLONGO, Patrizia   +3 more
openaire   +3 more sources