Results 21 to 30 of about 47,203 (289)

Investigating cell-specific effects of FMRP deficiency on spiny projection neurons in a mouse model of Fragile X syndrome

Frontiers in Cellular Neuroscience, 2023
IntroductionFragile X syndrome (FXS), resulting from a mutation in the Fmr1 gene, is the most common monogenic cause of autism and inherited intellectual disability.
Gabriele Giua, Gabriele Giua, Gabriele Giua, Olivier Lassalle, Olivier Lassalle, Olivier Lassalle, Leila Makrini-Maleville, Emmanuel Valjent, Pascale Chavis, Pascale Chavis, Pascale Chavis, Olivier J. J. Manzoni, Olivier J. J. Manzoni, Olivier J. J. Manzoni   +13 more
doaj   +1 more source

Changements observés au Canada dans la consommation de cannabis à des fins médicales pendant la pandémie de COVID-19

Promotion de la santé et prévention des maladies chroniques au Canada, 2023
IntroductionLa pandémie de COVID-19 a eu des effets négatifs généralisés sur la santé, notamment une perte de sécurité matérielle et une exacerbation des maladies mentales chez les populations à risque.
Stephanie Lake, Ziva D. Cooper, Kaye Ong, Philippe Lucas   +3 more
doaj   +1 more source

Sex-specific divergent maturational trajectories in the postnatal rat basolateral amygdala

iScience, 2022
Summary: In rodents and humans, the basolateral amygdala (BLA), essential for emotional behaviors, is profoundly reorganized during adolescence. We compared in both sexes the morphology, neuronal, and synaptic properties of BLA neurons in rats at puberty
Pauline Guily, Olivier Lassalle, Pascale Chavis, Olivier J. Manzoni   +3 more
doaj   +1 more source

Puff, Puff, Don’t Pass: harm reduction for cannabis use during a viral respiratory pandemic

Harm Reduction Journal, 2023
Background Prior to the COVID-19 pandemic, cannabis use social practices often involved sharing prepared cannabis (joints/blunts/cigarettes) and cannabis-related paraphernalia.
Ryan D. Assaf, Marjan Javanbakht, Pamina M. Gorbach, Onyebuchi A. Arah, Steven J. Shoptaw, Ziva D. Cooper   +5 more
doaj   +1 more source

Shifts in medical cannabis use in Canada during the COVID-19 pandemic

Health Promotion and Chronic Disease Prevention in Canada, 2023
IntroductionThe COVID-19 pandemic has had widespread secondary negative health impacts including loss of material security and exacerbation of mental illness in at-risk populations.
Stephanie Lake, Ziva D. Cooper, Kaye Ong, Philippe Lucas   +3 more
doaj   +1 more source

Cannabinoids in Medicine: A Multifaceted Exploration of Types, Therapeutic Applications, and Emerging Opportunities in Neurodegenerative Diseases and Cancer Therapy

Biomolecules, 2023
In this review article, we embark on a thorough exploration of cannabinoids, compounds that have garnered considerable attention for their potential therapeutic applications. Initially, this article delves into the fundamental background of cannabinoids,
Victor Voicu, Felix-Mircea Brehar, Corneliu Toader, Razvan-Adrian Covache-Busuioc, Antonio Daniel Corlatescu, Andrei Bordeianu, Horia Petre Costin, Bogdan-Gabriel Bratu, Luca-Andrei Glavan, Alexandru Vlad Ciurea   +9 more
doaj   +1 more source

Cannabinoids in Pediatrics [PDF]

The Journal of Pediatric Pharmacology and Therapeutics, 2017
Despite its controversial nature, the use of medical marijuana and cannabis-derived medicinal products grows more popular with each passing year. As of November 2016, over 40 states have passed legislation regarding the use of either medical marijuana or cannabidiol products. Many providers have started encountering patients experimenting with cannabis
Christopher T, Campbell, Marjorie Shaw, Phillips, Kalen, Manasco   +2 more
openaire   +2 more sources

Sex-dependent effects of in utero cannabinoid exposure on cortical function

eLife, 2018
Cannabinoids can cross the placenta, thus may interfere with fetal endocannabinoid signaling during neurodevelopment, causing long-lasting deficits.
Anissa Bara, Antonia Manduca, Axel Bernabeu, Milene Borsoi, Michela Serviado, Olivier Lassalle, Michelle Murphy, Jim Wager-Miller, Ken Mackie, Anne-Laure Pelissier-Alicot, Viviana Trezza, Olivier J Manzoni   +11 more
doaj   +1 more source

Cannabinoids and Epilepsy [PDF]

Neurotherapeutics, 2015
Cannabis has been used for centuries to treat seizures. Recent anecdotal reports, accumulating animal model data, and mechanistic insights have raised interest in cannabis-based antiepileptic therapies. In this study, we review current understanding of the endocannabinoid system, characterize the pro- and anticonvulsive effects of cannabinoids [e.g ...
Evan C, Rosenberg, Richard W, Tsien, Benjamin J, Whalley, Orrin, Devinsky   +3 more
openaire   +2 more sources

Cannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction

Cell Reports, 2020
Summary: Cannabinoids are reported to rescue cocaine-induced seizures (CISs), a severe complication in cocaine users. However, the molecular targets for cannabinoid therapy of CISs remain unclear.
Guichang Zou, Xin Zuo, Kai Chen, Yushu Ge, Xiaoqun Wang, Guangwei Xu, Huan Wang, Chenjian Miao, Zhenyu Xu, Shuangshuang Tian, Zhen Wang, Yifeng Zhou, Wei Wei, Guangming Huang, Dan Liu, Wei Xiong   +15 more
doaj   +1 more source