Results 31 to 40 of about 396,548 (332)

Determining zebrafish dorsal organizer size by a negative feedback loop between canonical/non-canonical Wnts and Tlr4/NFκB

Nature Communications, 2023
In vertebrate embryos, the canonical Wnt ligand primes the formation of dorsal organizers that govern dorsal-ventral patterns by secreting BMP antagonists.
Juqi Zou, Satoshi Anai, Satoshi Ota, Shizuka Ishitani, Masayuki Oginuma, Tohru Ishitani   +5 more
doaj   +1 more source

Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)

International Journal of Oncology, 2017
Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-differentiation, undergo epigenetic, epithelial-mesenchymal, immunological and metabolic reprogramming to adapt to the tumor microenvironment and survive host ...
M. Katoh
semanticscholar   +1 more source

Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate

Nature Communications, 2020
The choroid plexus secretes cerebrospinal fluid and is critical for the development and function of the brain. In the telencephalon, the choroid plexus epithelium arises from the Wnt- expressing cortical hem.
Arpan Parichha, Varun Suresh, Mallika Chatterjee, Aditya Kshirsagar, Lihi Ben-Reuven, T. Olender, M. M. Taketo, V. Radošević, Mihaela Bobić-Rasonja, Sara Trnski, M. Holtzman, N. Jovanov-Milošević, O. Reiner, S. Tole   +13 more
semanticscholar   +1 more source

Canonical Wnt signaling in diabetic retinopathy

Vision Research, 2017
Diabetic retinopathy (DR) is a common eye complication of diabetes, and the pathogenic mechanism of DR is still under investigation. The canonical Wnt signaling pathway is an evolutionarily conserved pathway that plays fundamental roles in embryogenesis and adult tissue homeostasis.
Qian, Chen, Jian-Xing, Ma
openaire   +2 more sources

Transient Deregulation of Canonical Wnt Signaling in Developing Pyramidal Neurons Leads to Dendritic Defects and Impaired Behavior

Cell Reports, 2019
Summary: During development, the precise implementation of molecular programs is a key determinant of proper dendritic development. Here, we demonstrate that canonical Wnt signaling is active in dendritic bundle-forming layer II pyramidal neurons of the ...
Beatrice Viale, Lin Song, Volodymyr Petrenko, Anne-Laure Wenger Combremont, Alessandro Contestabile, Riccardo Bocchi, Patrick Salmon, Alan Carleton, Lijia An, Laszlo Vutskits, Jozsef Zoltan Kiss   +10 more
doaj   +1 more source

Transcriptomic Identification of Draxin-Responsive Targets During Cranial Neural Crest EMT

Frontiers in Physiology, 2021
Canonical Wnt signaling plays an essential role in proper craniofacial morphogenesis, at least partially due to regulation of various aspects of cranial neural crest development.
Erica J. Hutchins, Michael L. Piacentino, Marianne E. Bronner   +2 more
doaj   +1 more source

Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/β-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis

Frontiers in Immunology, 2018
Inflammation and oxidative stress are common and co-substantial pathological processes accompanying, promoting, and even initiating numerous cancers.
Alexandre Vallée, Y. Lecarpentier
semanticscholar   +1 more source

Non-canonical Wnt signaling in the eye

Progress in Retinal and Eye Research, 2023
Wnt signaling comprises a group of complex signal transduction pathways that play critical roles in cell proliferation, differentiation, and apoptosis during development, as well as in stem cell maintenance and adult tissue homeostasis. Wnt pathways are classified into two major groups, canonical (β-catenin-dependent) or non-canonical (β-catenin ...
Shah, Ruchi, Amador, Cynthia, Chun, Steven T, Ghiam, Sean, Saghizadeh, Mehrnoosh, Kramerov, Andrei A, Ljubimov, Alexander V   +6 more
openaire   +3 more sources

Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells.

PLoS ONE, 2015
The Wnt system is highly complex and is comprised of canonical and non-canonical pathways leading to the activation of gene expression. Our aim was to examine changes in the expression of Wnt ligands and regulators during hepatic stellate cell (HSC ...
Laura Corbett, Jelena Mann, Derek A Mann
doaj   +1 more source

Role of Wnt canonical pathway in hematological malignancies

Journal of Hematology & Oncology, 2010
Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the pathogenesis of many carcinomas.
Wang Xin, GE Xueling
doaj   +1 more source