Results 51 to 60 of about 396,548 (332)
Non-canonical WNT signalling in the lung [PDF]
Journal of Biochemistry, 2015 The role of WNT signalling in metazoan organogenesis has been a topic of widespread interest. In the lung, while the role of canonical WNT signalling has been examined in some detail by multiple studies, the non-canonical WNT signalling has received limited attention.
Changgong, Li +3 more
openaire +2 more sources
Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways
eLife, 2015 The intracellular signaling molecule Dishevelled (Dvl) mediates canonical and non-canonical Wnt signaling via its PDZ domain. Different pathways diverge at this point by a mechanism that remains unclear.
Ho-Jin Lee, De-Li Shi, Jie J Zheng
doaj +1 more source
The canonical Wnt/β-catenin pathway: From the history of its discovery to clinical application [PDF]
Терапевтический архив, 2016 The Wnt/β signaling pathway (Wnt-SP) is a phylogenetically ancient mechanism that regulates development and maintains tissue homeostasis through the control of cell proliferation, differentiation, migration, and apoptosis.
T A Grebennikova +3 more
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eLife, 2019 Morphogenesis of hierarchical vascular networks depends on the integration of multiple biomechanical signals by endothelial cells, the cells lining the interior of blood vessels.
J. R. Carvalho +9 more
semanticscholar +1 more source
Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease
Neural Regeneration Research, 2018 Alzheimer's disease (AD) is the most common form of dementia in the older population, however, the precise cause of the disease is unknown. The neuropathology is characterized by the presence of aggregates formed by amyloid-β (Aβ) peptide and ...
Cheril Tapia-Rojas, N. Inestrosa
semanticscholar +1 more source
Canonical Wnt signaling negatively regulates platelet function [PDF]
Proceedings of the National Academy of Sciences, 2009 Wnts regulate important intracellular signaling events, and dysregulation of the Wnt pathway has been linked to human disease. Here, we uncover numerous Wnt canonical effectors in human platelets where Wnts, their receptors, and downstream signaling components have not been previously described.
Brian M. Steele +9 more
openalex +3 more sources
Frontiers in Oncology, 2023 IntroductionCancer Stem Cells (CSC) are responsible for maintaining tumor growth, chemoresistance, and metastasis. Therefore, understanding their characteristics is critical to progress in cancer therapy.
Miguel Angel Sarabia-Sánchez +5 more
doaj +1 more source
New Advances in Canonical Wnt/β-Catenin Signaling in Cancer
Cancer Management and Research, 2020 Wnt/β-catenin-mediated signaling is a key pathway regulating tissue growth and development, and tumorigenesis, and has received increasing attention in recent years. In addition to participating in healthy tissue and organ development, ectopic activation
Xiaolan Wen +4 more
semanticscholar +1 more source
OncoTarget, 2017 Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can occur 4 to 12 months after radiation therapy. This process worsens with time and years.
Alexandre Vallée +3 more
semanticscholar +1 more source
Canonical Wnt Signaling Pathway on Polarity Formation of Utricle Hair Cells
Neural Plasticity, 2021 As part of the inner ear, the vestibular system is responsible for sense of balance, which consists of three semicircular canals, the utricle, and the saccule.
Di Deng +8 more
doaj +1 more source