Results 91 to 100 of about 76,053 (241)

Identification and cost of adverse events in metastatic breast cancer in taxane and capecitabine based regimens. [PDF]

, 2014
PurposeWe sought to compare the economic impact of treatment-related adverse events (AEs) in patients with metastatic breast cancer (mBC) using taxane- or capecitabine-based treatment regimens as either first- or second-line (FL or SL) therapy in the US ...
Brammer, Melissa, Hansen, Ryan N, Hurvitz, Sara A, Kamath, Tripthi, Lalla, Deepa, Masaquel, Anthony, Ramsey, Scott D, Sullivan, Sean D   +7 more
core   +1 more source

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, EarlyView.
ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source

Integration Analysis of Bayesian and Machine Learning for Heterogeneity, Biomarkers, and Optimal Combination Regimens of Pucotenlimab in Solid Tumors. [PDF]

Cancer Med
ABSTRACT The efficacy of PD‐1 inhibitor pucotenlimab (HX008) in solid tumors exhibits heterogeneity. This study integrated data from 6 clinical trials (covering gastric/gastroesophageal junction cancer, triple‐negative breast cancer, melanoma, and dMMR/MSI‐H solid tumors) using Bayesian meta‐analysis, machine learning (optimal XGBoost AUC = 0.86), and ...
He Y, Gao C, Zhang S, Hao Y, He S, Peng K, Li L.   +6 more
europepmc   +2 more sources

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Capecitabine-induced coronary artery vasospasm in a patient who previously experienced a similar episode with fluorouracil therapy

Türk Kardiyoloji Derneği Arşivi, 2016
Capecitabine is a chemotherapeutic agent used in the treatment of metastatic colon cancer and metastatic breast cancer. It is metabolized into fluorouracil (5-FU) in the liver; hence, its mechanism of action is similar to that of 5-FU.
Uğur Nadir Karakulak, Elifcan Aladağ, Naresh Maharjan, Kenan Övünç   +3 more
doaj   +1 more source

Characterisation of the immune-related transcriptome in resected biliary tract cancers [PDF]

, 2017
Although biliary tract cancers (BTCs) are known to have an inflammatory component, a detailed characterisation of immune-related transcripts has never been performed.
Braconi, Chiara, Carotenuto, Pietro, Cascione, Luciano, Cillo, Umberto, Fassan, Matteo, Ghidini, Michele, Hahne, Jens C., Lampis, Andrea, Mescoli, Claudia, Previdi, Maria Chiara, Raj, Maya, Rimassa, Lorenza, Roncalli, Massimo, Rugge, Massimo, Said-Huntingford, Ian, Santoro, Armando, Torzilli, Guido, Trevisani, Francesco, Valeri, Nicola, Zerbi, Alessandro   +19 more
core   +3 more sources

Palbociclib in the Treatment of HR+/ HER2‐ Advanced or Metastatic Breast Cancer in Australia: A Real‐World Retrospective Analysis

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This study investigated the real‐world use of CDK4/6 inhibitors in Australian patients with HR+/HER2‐ advanced or metastatic breast cancer, providing data on patient demographics, treatment patterns, and outcomes with palbociclib. ABSTRACT Background There is limited real‐world data on the use of CDK4/6 inhibitors in Australian patients with HR+/HER2 ...
Louise Nott, Eugene Moylan, Maree Colosimo, Giles Stratton, Thomas Chiu, Mahsa H. Kouhkamari, Maureen Hitschfeld, Jessica Michie, Richard De Boer   +8 more
wiley   +1 more source

044. Unlocking The Potential: Comparing The Effects of Probiotics Alone and in Combination with Capecitabine Against Colorectal Cancer in Rats

JBN (Jurnal Bedah Nasional)
Background: Colorectal cancer (CRC) is a leading cause of cancer deaths globally. While capecitabine is an effective chemotherapy for CRC, its use is limited by side effects and resistance. This has sparked interest in combining capecitabine with natural
Reza Yuneri Putri, Suci Berlian Hemilton, Muhammad Iqbal Rivai, Rini Suswita, Irwan Irwan, Avit Suchitra   +5 more
doaj   +1 more source

Quantification and expert evaluation of evidence for chemopredictive biomarkers to personalize cancer treatment. [PDF]

, 2017
Predictive biomarkers have the potential to facilitate cancer precision medicine by guiding the optimal choice of therapies for patients. However, clinicians are faced with an enormous volume of often-contradictory evidence regarding the therapeutic ...
Beckman, Robert A., Boca, Simina M., Brody, Jonathan R., Madhavan, Subha, Marshall, John L., Pishvaian, Michael J., Rao, Shruti, Riazi, Shahla, Yabar, Cinthya S.   +8 more
core   +1 more source

Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski, Rachel Dear, Sanjeev Kumar, Hilary Martin, Dhanusha Sabanathan, Stephen J. Luen, Belinda Yeo   +6 more
wiley   +1 more source