Results 81 to 90 of about 47,826 (189)

Comparison of Thrombocytopenia and Splenomegaly in Locally Advanced Rectal Cancer Patients Receiving Total Neoadjuvant Therapy With and Without Immunotherapy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Background Thrombocytopenia is a common toxicity of oxaliplatin‐based chemotherapy and may be linked to hepatic sinusoidal obstruction and splenic enlargement. In the TORCH trial, adding PD‐1 blockade to an oxaliplatin‐containing total neoadjuvant therapy (TNT) regimen improved tumor response in patients with locally advanced rectal cancer ...
Shuwen Li, Mingxu Yan, Qiong Ma, Yiqun Sun, Zhen Zhang, Lijun Shen, Juefeng Wan, Hui Zhang, Ruiyan Wu, Fan Xia, Yaqi Wang   +10 more
wiley   +1 more source

Traditional Chinese Medicine Combined With Chemotherapy for Mammary Paget's Disease With Multifocal Heterogeneous Breast Cancer: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
This flowchart systematically outlines the full diagnostic and therapeutic pathway of mammary Paget's disease with ipsilateral multifocal breast cancer, covering preoperative radiological assessment, postoperative histopathological confirmation of inter‐lesional molecular heterogeneity, individualized multimodal treatment, recurrence‐free follow‐up ...
Hongyu Cheng, Jiayin Tang, Chang Yao
wiley   +1 more source

The evolving landscape of the Warburg effect in gastric cancer: From molecular mechanisms to targeted therapy

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu, Pan Li, Zizhuo Li, Jie Li, Chenggang Zhang, Yihua Wang, Weiming Kang, Xin Ye   +7 more
wiley   +1 more source

Prognostic and Predictive Role of Circulating Tumor DNA in Locally Advanced Rectal Cancer Managed With Total Neoadjuvant Therapy: A Systematic Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Circulating tumor DNA (ctDNA) has emerged as a promising biomarker of tumor burden and minimal residual disease. As total neoadjuvant therapy (TNT) increasingly supports organ‐preserving strategies in locally advanced rectal cancer (LARC), reliable markers of treatment response are needed.
Faizan Bashir, Qurat‐ul‐Aine Bhat, Jayden Allegakoen, Dorsa Shekouh, Sajida Zaiter   +4 more
wiley   +1 more source

The Dual Role of the Gut Microbiota in Cancer Chemoresistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi, Aisa Bahar, Meisam Khazaei, Mohammad Reza Arabestani   +3 more
wiley   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

A pilot study investigating plasma pharmacokinetics and tolerance of oral capecitabine in carcinoma-bearing dogs

BMC Veterinary Research
Background Capecitabine is an oral prodrug of the active metabolite 5-fluorouracil, which has been used effectively in human colorectal, head and neck, and mammary carcinomas.
Sarah Wetzel, Janean Fidel, Dale Whittington, Nicolas F. Villarino   +3 more
doaj   +1 more source

Effects of a Psycho‐Behavioural Intervention on Cancer‐Related Fatigue Among Patients With Colorectal Cancer: A Pilot Randomised Controlled Trial

Psycho-Oncology, Volume 35, Issue 8, August 2026.
ABSTRACT Background Post‐treatment colorectal cancer patients commonly experience cancer‐related fatigue (CRF), yet few interventions address this concern. Objectives To examine the feasibility, acceptability, and preliminary effects of a psycho‐behavioural intervention on CRF and other health outcomes in this population.
Jinling Lu, Yuen Yu Chong
wiley   +1 more source

A Tale of Two Cell Lines: Characterization of Differential Efficacy of Small Molecule Drugs Cediranib and NU‐7441 on Primary Versus Metastatic Colorectal Cancer

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Colorectal cancer is recognized as one of the leading causes of cancer death amongst both sexes in the U.S. Despite rigorous screening, those diagnosed with colon cancer often face poor prognosis, and approximately 70% of affected patients will develop metastatic relapse. The investigation of colon carcinoma cell lines' genetic variability and
Josephine D. Tsang, Cai M. Roberts
wiley   +1 more source