Results 21 to 30 of about 190,613 (246)

Cellular changes at the glia-neuro-vascular interface in definite idiopathic normal pressure hydrocephalus

Frontiers in Cellular Neuroscience, 2022
Idiopathic normal pressure hydrocephalus (iNPH) is a subtype of dementia with overlap toward Alzheimer's disease. Both diseases show deposition of the toxic metabolites amyloid-β and tau in brain.
Per Kristian Eide, Per Kristian Eide
doaj   +1 more source

MECHANISM OF PARTIAL METAL MELT STRATIFICATION IN CAPILLARS [PDF]

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2013
Experimental results of diameter, inclination, angle and length effects on metal melt stratification rate are represented. These relationships determined experimentally were compared with relationships obtained on the basis of simple hydrodynamics ...
N.P. Ouglev
doaj  

Specificity of lipoprotein lipase binding to endothelial cells.

Journal of Lipid Research, 1993
Lipoprotein lipase (LPL) hydrolyzes circulating lipoprotein triglyceride molecules while it is associated with the luminal surface of capillary endothelial cells. The precise molecular mechanism by which LPL attaches to these cells is unknown.
MF Stins, P Sivaram, A Sasaki, IJ Goldberg   +3 more
doaj   +1 more source

Neurovascular Uncoupling Is Linked to Microcirculatory Dysfunction in Regions Outside the Ischemic Core Following Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Normal brain function depends on the ability of the vasculature to increase blood flow to regions with high metabolic demands. Impaired neurovascular coupling, such as the local hyperemic response to neuronal activity, may contribute to poor ...
Christian Staehr, John T. Giblin, Eugenio Gutiérrez‐Jiménez, Halvor Ø. Guldbrandsen, Jianbo Tang, Shaun L. Sandow, David A. Boas, Vladimir V. Matchkov   +7 more
doaj   +1 more source

Capillary orbits [PDF]

Nature Communications, 2019
AbstractMillimeter-sized objects trapped at a liquid surface distort the interface by their weight, which in turn attracts them towards each other. This ubiquitous phenomenon, colloquially called the “Cheerios effect” is seen in the clumping of cereals in a breakfast bowl, and turns out to be a highly promising route towards controlled self-assembly of
Gauthier, Anaïs, van Der Meer, Devaraj, Snoeijer, Jacco, Lajoinie, Guillaume   +3 more
openaire   +4 more sources

An unusual presentation of Goodpasture syndrome

Saudi Journal of Anaesthesia, 2023
Goodpasture disease is an anti–glomerular basement membrane (anti-GBM) disease that manifests as progressive glomerulopathy and alveolar hemorrhage. Our case was a 68-year-old female who presented with decompensated liver disease (DCLD) with no prior ...
Jisa George, Buddhan Rajarathinam, Rajkumar Kulasekaran, Pranjali Kurhekar   +3 more
doaj   +1 more source

Structural Microangiopathies in Skeletal Muscle Related to Systemic Vascular Pathologies in Humans

Frontiers in Physiology, 2020
It is unclear how microangiopathic changes in skeletal muscle vary among systemic vascular pathologies. We therefore analyzed the capillary fine structure in skeletal muscle from patients with arterial hypertension (HYPT), diabetes mellitus type 2 (T2DM)
Oliver Baum, Jonathan Bernd, Samuel Becker, Adolfo Odriozola, Benoît Zuber, Stefan A. Tschanz, Andreas Zakrzewicz, Stuart Egginton, Janine Berkholz   +8 more
doaj   +1 more source

Capillary malformations

Journal of Clinical Investigation
Capillary malformation (CM), or port wine birthmark, is a cutaneous congenital vascular anomaly that occurs in 0.1%-2% of newborns. Patients with a CM localized on the forehead have an increased risk of developing a neurocutaneous disorder called encephalotrigeminal angiomatosis or Sturge-Weber syndrome (SWS), with complications including seizure ...
Hammill, Adrienne M., Boscolo, Elisa
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source