Results 61 to 70 of about 76,093 (303)

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Molecular basis for heat desensitization of TRPV1 ion channels. [PDF]

, 2019
The transient receptor potential vanilloid 1 (TRPV1) ion channel is a prototypical molecular sensor for noxious heat in mammals. Its role in sustained heat response remains poorly understood, because rapid heat-induced desensitization (Dh) follows ...
Kamau, Peter Muiruri, Lai, Ren, Li, Bowen, Luo, Lei, Wang, Yunfei, Xu, Lizhen, Yang, Fan, Yang, Shilong, Zheng, Jie   +8 more
core   +2 more sources

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu, Guiyang Zhang, Liangping Ni, Gaolin Liang, Fang Yang, Ye Zhang, Shufang He   +15 more
wiley   +1 more source

The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes [PDF]

, 2005
The boundary cap (BC) is a transient neural crest-derived group of cells located at the dorsal root entry zone (DREZ) that have been shown to differentiate into sensory neurons and glia in vivo.
Cederberg, A, Enerback, S, Ernfors, P, Heglind, M, Hjerling-Leffler, J, Koltzenburg, M, Marmigere, F   +6 more
core   +2 more sources

Selbstassemblierte (Aza‐)BODIPY Farbstoffe für Biomedizinische In Vivo Bildgebung

Angewandte Chemie, EarlyView.
Dieses Minireview klassifiziert (Aza‐)BODIPY‐Farbstoffe anhand ihrer molekularen Stapelungsmodi und Aggregattypen (H‐, oblique‐ oder J‐Typ) in wässrigen Medien und setzt diese Merkmale in Beziehung zu ihrer multimodalen Bildgebungsleistung. Durch die Verknüpfung von molekularem Design, Exzitonenkopplung und pfadabhängiger Assemblierung stellen wir ...
Antonia Albers, Max Masthoff, Gustavo Fernández   +2 more
wiley   +1 more source

Optical study to identify and quantify capsaicin in optical window

Heliyon, 2021
Capsaicin is an active compound in hot peppers. It has been studied for its health benefits for humans. Optical spectroscopy is an important tool for determining the optical properties or chemical composition of matter.
Manuel Abraham López Pacheco, José Javier Báez Rojas, Jorge Castro-Ramos, José Fabian Villa Manríquez, Karen Esmonde-White   +4 more
doaj   +1 more source

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]

, 2019
© 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta, Czoty, Paul W., DeLoid, Heather B., Ding, Huiping, Hsu, Fang Chi, Husbands, Stephen M., Kiguchi, Norikazu, Ko, Mei Chuan, Sukhtankar, Devki D., Toll, Lawrence   +9 more
core   +5 more sources

Self‐Assembled (Aza)BODIPY Dyes for Biomedical in Vivo Imaging

Angewandte Chemie International Edition, EarlyView.
This minireview classifies (aza)BODIPY dyes according to their molecular stacking modes and aggregate types (H‐, oblique‐, or J‐type) in aqueous media, correlating these features with their multimodal imaging performance. By linking molecular design, exciton coupling, and pathway‐dependent assembly, we provide a framework for engineering next ...
Antonia Albers, Max Masthoff, Gustavo Fernández   +2 more
wiley   +1 more source

The impact of topical capsaicin application on the muscle metaboreflex and microvascular responsiveness

Physiological Reports
Topical capsaicin reduces metaboreflex responses during post‐exercise circulatory arrest (PECA) in males, but its effects in females and on microvascular responsiveness in either sex remain unclear.
Nikolaus D. Carpenter, Aaron E. Wahl, Alec L. E. Butenas, Sherwin Toribio, Jacob T. Caldwell   +4 more
doaj   +1 more source

Modifications of Capsaicin-Sensitive Neurons in Isolated Guinea Pig Ileum by [6]-Gingerol and Lafutidine

Journal of Pharmacological Sciences, 2003
A segment of guinea pig ileum was used to confirm the hypothesis that [6]-gingerol and lafutidine interact with capsaicin-sensitive neurons. Addition of 30 and 100 μM [6]-gingerol (a pungent constituent of ginger) induced contraction of the ileum ...
Akiyoshi Someya, Shunji Horie, Hisashi Yamamoto, Toshihiko Murayama   +3 more
doaj   +1 more source