Results 61 to 70 of about 28,315 (199)

Efficacy and Safety of Diclofenac + Capsaicin Gel in Patients with Acute Back/Neck Pain: A Multicenter Randomized Controlled Study

Pain and Therapy, 2020
Introduction Back and neck pain are common musculoskeletal disorders. Topical non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used to reduce pain and inflammation with fewer systemic side effects and drug interactions compared with oral ...
Hans-Georg Predel, Caty Ebel-Bitoun, Barbara Peil, Thomas W. Weiser, Robert Lange   +4 more
doaj   +1 more source

Research Progress on Upper Airway Cough Syndrome

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source

The Antiproliferative and Apoptotic Effects of Capsaicin on an Oral Squamous Cancer Cell Line of Asian Origin, ORL-48

Medicina, 2019
Background and Objectives: The antitumor activities of capsaicin on various types of cancer cell lines have been reported but the effect of capsaicin on oral cancer, which is prevalent among Asians, are very limited. Thus, this study aimed to investigate
Mohammad Firdaus Kamaruddin, Mohammad Zakir Hossain, Aied Mohamed Alabsi, Marina Mohd Bakri   +3 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brain

Journal of Dental Sciences, 2018
Background/purpose: Although it has been reported that capsaicin ingestion has effects of protecting stomach mucosa and promoting energy consumption, physiological responses to oral stimulation with capsaicin has not been elucidated.
Yoko Kono, Ayako Kubota, Masato Taira, Narumi Katsuyama, Kumiko Sugimoto   +4 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Exploring the effect of capsaicin on gene expression and chemotherapy sensitization in gastric cancer cells

European Journal of Medical Research
Background Capsaicin, phytochemical component in red hot chili peppers, has previously been demonstrated to exhibit antitumor effect in various cancer type.
Weijian Meng, Kun Xie, Zhihong Qi, Rui Zhang, Jie Shen   +4 more
doaj   +1 more source

The brain mechanisms underlying the perception of pungent taste of capsaicin and the subsequent autonomic responses.

Frontiers in Human Neuroscience, 2016
In a human fMRI study, it has been demonstrated that tasting and ingesting capsaicin activate the ventral part of the middle and posterior short gyri (M/PSG) of the insula which is known as the primary gustatory area, suggesting that capsaicin is ...
Shinpei eKawakami, Shinpei eKawakami, Hajime eSato, Akihiro T Sasaki, Akihiro T Sasaki, Akihiro T Sasaki, Hiroki C Tanabe, Yumiko eYoshida, Mitsuru eSaito, Hiroki eToyoda, Norihiro eSadato, Youngnam eKang   +11 more
doaj   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin.

PLoS ONE, 2013
Previous results demonstrated that capsaicin induces the reversible tight junctions (TJ) opening via cofilin activation. The present study investigated the mechanisms underlying the reversible TJ opening and compared the effect to the irreversible ...
Tomoko Shiobara, Takeo Usui, Junkyu Han, Hiroko Isoda, Yoko Nagumo   +4 more
doaj   +1 more source