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Journal of Molecular Cell Biology, 2023 Abstract Lenacapavir, targeting the human immunodeficiency virus type-1 (HIV-1) capsid, is the first-in-class antiretroviral drug recently approved for clinical use. The development of Lenacapavir is attributed to the remarkable progress in our understanding of the capsid protein made during the last few years.
Ian A Taylor, Ariberto Fassati
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Nanomedicine and Phage Capsids [PDF]
Viruses, 2018 Studies of phage capsids have at least three potential interfaces with nanomedicine. First, investigation of phage capsid states potentially will provide therapies targeted to similar states of pathogenic viruses. Recently detected, altered radius-states of phage T3 capsids include those probably related to intermediate states of DNA injection and DNA ...
Philip Serwer, Elena T. Wright
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The Astrovirus Capsid: A Review [PDF]
Viruses, 2017 Astroviruses are enterically transmitted viruses that cause infections in mammalian and avian species. Astroviruses are nonenveloped, icosahedral viruses comprised of a capsid protein shell and a positive-sense, single-stranded RNA genome. The capsid protein undergoes dramatic proteolytic processing both inside and outside of the host cell, resulting ...
Arias, Carlos F, DuBois, Rebecca M
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How to Assemble a Capsid [PDF]
Cell, 2007 Retroviral capsids are composed of hexagonal arrays of the viral CA protein. In this issue of Cell, Ganser-Pornillos et al. (2007) provide a molecular model of the hexagonal HIV-1 CA lattice obtained from a new electron cryomicroscopic reconstruction. This study reveals the three principal stabilizing interfaces in the capsid lattice and explains how ...
Wesley I. Sundquist, Christopher P. Hill
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Maturation of Papillomavirus Capsids [PDF]
Journal of Virology, 2005 ABSTRACT The papillomavirus capsid is a nonenveloped icosahedral shell formed by the viral major structural protein, L1. It is known that disulfide bonds between neighboring L1 molecules help to stabilize the capsid. However, the kinetics of inter-L1 disulfide bond formation during particle morphogenesis have not previously been examined.
Christopher B. Buck +4 more
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A Unique Role of the Human Cytomegalovirus Small Capsid Protein in Capsid Assembly
mBio, 2022 Human cytomegalovirus (HCMV) is a ubiquitous pathogen causing life-threatening disease in immunocompromised individuals. Virus-specific processes such as capsid assembly and genome packaging can be exploited to design new antiviral strategies.
Eva Maria Borst +8 more
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Mechanical properties of viral capsids [PDF]
Physical Review E, 2005 12 ...
Zandi, Roya, Reguera, D. (David)
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Architecture of the Adenovirus Capsid [PDF]
Journal of Bacteriology, 1965 Smith, Kendall O. (Baylor University College of Medicine, Houston, Tex.), Warren D. Gehle, and Melvin D. Trousdale . Architecture of the adenovirus capsid. J. Bacteriol. 90: 254–261.
Kendall O. Smith +2 more
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Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
eLife, 2022 The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use. Here, we investigate the effect of lenacapavir on HIV capsid stability and uncoating.
Chantal L Márquez +12 more
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The A, B, Cs of Herpesvirus Capsids [PDF]
Viruses, 2015 Assembly of herpesvirus nucleocapsids shares significant similarities with the assembly of tailed dsDNA bacteriophages; however, important differences exist. A unique feature of herpesviruses is the presence of different mature capsid forms in the host cell nucleus during infection.
Ritesh Tandon +2 more
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