Results 191 to 200 of about 177,162 (260)

AAVrh32.33 capsid demonstrates unexpected dermal tropism regardless of immunodominant epitope. [PDF]

Mol Ther
Arjomandnejad M, Essien K, Sylvia K, Blackwood M, Tutto A, Katz E, Tang Q, Harris JE, Keeler AM.   +8 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, Volume 16, Issue 6, Page 1132-1141, June 2026.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Viral Pathogens Threatening Cage‐Cultured Nile Tilapia in Lake Victoria: Epidemiology, Emerging Risks and Integrated Health Management Strategies

Aquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.
ABSTRACT The rapid expansion of cage culture for Nile tilapia (Oreochromis niloticus) in Lake Victoria is central to food security and profitable development in East Africa. Nevertheless, viral conditions affect the sustainability of this sector, with significant imbalances in livelihood, trade and aquaculture adaptability.
Richard S. Komba, Chacha J. Mwita
wiley   +1 more source

Regulation of HPV-16 infection by ubiquitination of the L1 major capsid protein. [PDF]

J Virol
Trejo-Cerro O, Bergant Marušič M, Wlodarczyk P, Repnik U, Lovšin N, Myers MP, Garcea RL, Banks L, Broniarczyk J.   +8 more
europepmc   +1 more source

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy

Aggregate, Volume 7, Issue 6, June 2026.
Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding   +5 more
wiley   +1 more source

Many paths, similar destinations: viruses and bacterial microcompartments form polyhedra inside cells. [PDF]

J Virol
Parent KN, Kerfeld CA.
europepmc   +1 more source

Transient prophylactic immunosuppression with abatacept or dasatinib prevents immune responses in AAV gene transfer. [PDF]

Mol Ther
Xicluna R, Yamada K, Gonzalez-Visiedos M, Greenwood CM, Zaugg D, Waiz D, Steiner G, Hahn K, Schwandt T, Otteneder MB, Biswas M, Muñoz-Melero M, Kumar SRP, Herzog RW, Haegel H.   +14 more
europepmc   +1 more source

Relationships Among Maternal Epstein–Barr Virus Antibodies, COVID‐19, and Stress in Mothers up to 1‐Year Postpartum

American Journal of Human Biology, Volume 38, Issue 6, June 2026.
ABSTRACT Objectives Both psychosocial stress and current infection can increase the likelihood of reactivation of latent Epstein–Barr virus (EBV). Pregnancy and infection with SARS‐CoV‐2 can be stressful and modulate immune function. However, it is unknown how SARS‐CoV‐2 infection and stress further interact among postpartum women to affect EBV antigen
Emma Anastasi, Delaney J. Glass, Tiffany D. Pan, Eleanor Brindle, Beatrice Caffe, Caroline B. Smith, Amanda E. Kunkle, Maia A. Kent, Alexandra D. Navarrete, Christina D. W. Pace, Dan T. A. Eisenberg, Ryan M. Pace, Janet E. Williams, Sylvia H. Ley, Celestina Barbosa‐Leiker, Mark A. McGuire, Michelle K. McGuire, Courtney L. Meehan, Melanie A. Martin   +18 more
wiley   +1 more source

Structural organization of HBV pgRNA genome driven by phase separation in capsid confinement. [PDF]

Nat Commun
Bian Y, Pan H, Mao J, He Y, Wang Y, Cao Y, Li W, Wang W.   +7 more
europepmc   +1 more source

Enhanced Recombinant Adeno‐Associated Virus (rAAV) Biomanufacturing: Design of Experiment (DOE) Enabled Transfection Optimization for Maximum Full Capsid Yield and Robust Scale‐Up

Biotechnology Journal, Volume 21, Issue 6, June 2026.
Graphical Abstract and Lay Summary The graphic presents our 2‐stage DOE approach used for transfection optimization to produce rAAV5 consisting of a screening DOE to identify significant factors, followed by an RSD for optimization. Optimal conditions were scaled up from 6‐well plates to a 50L WAVE reactor resulting in > 60% full capsids at scale ...
Alexandra Bogdanovic, Nicholas Donohue, Brian Glennon, Susan Mc Donnell, Jessica Whelan   +4 more
wiley   +1 more source