Results 31 to 40 of about 174,454 (241)

Host-driven evolution of PCV2: insights into genetic diversity and adaptation

Frontiers in Immunology
IntroductionsPorcine circovirus type 2 (PCV2) is a significant pathogen in swine, exhibiting notable genetic and phenotypic diversity. This study explores the evolutionary mechanisms influencing PCV2 variability, emphasizing the role of viral features ...
Giovanni Franzo, Matteo Legnardi, Francesca Poletto, Riccardo Baston, Mattia Cecchinato, Michele Drigo, Claudia Maria Tucciarone   +6 more
doaj   +1 more source

Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines

Viruses, 2020
Capsid-like particles (CLPs) are multimeric, repetitive assemblies of recombinant viral capsid proteins, which are highly immunogenic due to their structural similarity to wild-type viruses.
Kara-Lee Aves, Louise Goksøyr, Adam F. Sander   +2 more
doaj   +1 more source

Interplay between Host tRNAs and HIV-1: A Structural Perspective

Viruses, 2021
The cellular metabolism of host tRNAs and life cycle of HIV-1 cross paths at several key virus–host interfaces. Emerging data suggest a multi-faceted interplay between host tRNAs and HIV-1 that plays essential roles, both structural and regulatory, in ...
Jinwei Zhang
doaj   +1 more source

Capsids and Genomes of Jumbo-Sized Bacteriophages Reveal the Evolutionary Reach of the HK97 Fold

mBio, 2017
Large icosahedral viruses that infect bacteria represent an extreme of the coevolution of capsids and the genomes they accommodate. One subset of these large viruses is the jumbophages, tailed phages with double-stranded DNA genomes of at least 200,000 ...
Jianfei Hua, Alexis Huet, Carlos A. Lopez, Katerina Toropova, Welkin H. Pope, Robert L. Duda, Roger W. Hendrix, James F. Conway   +7 more
doaj   +1 more source

Advances in Recombinant Adeno-Associated Virus Vectors for Neurodegenerative Diseases

Biomedicines, 2023
Recombinant adeno-associated virus (rAAV) vectors are gene therapy delivery tools that offer a promising platform for the treatment of neurodegenerative diseases. Keeping up with developments in this fast-moving area of research is a challenge.
Leyao Li, Lakshmy Vasan, Bryan Kartono, Kevan Clifford, Ahmadreza Attarpour, Raghav Sharma, Matthew Mandrozos, Ain Kim, Wenda Zhao, Ari Belotserkovsky, Claire Verkuyl, Gerold Schmitt-Ulms   +11 more
doaj   +1 more source

HIV-1 infection regulates gene expression by altering alternative polyadenylation correlated with CPSF6 and CPSF5 redistribution

mBio
HIV-1 viral core transport to the nucleus, an early infection event, triggers the redistribution of cleavage and polyadenylation specificity factors (CPSF) 5 and CPSF6 to nuclear speckles, forming puncta-like structures.
Charlotte Luchsinger, Annie Zhi Dai, Hari Yalamanchili, Aiswarya Balakrishnan, Kai-Lieh Huang, Cinzia Bertelli, Bin Cui, Ramon Lorenzo-Redondo, Eric J. Wagner, Felipe Diaz-Griffero   +9 more
doaj   +1 more source

Overlap Intensity: An ImageJ Macro for Analyzing the HIV-1 In Situ Uncoating Assay

Viruses, 2021
Capsid uncoating is at the crossroads of early steps in HIV-1 replication. In recent years, the development of novel assays has expanded how HIV-1 uncoating can be studied.
Zachary Ingram, Hannah Matheney, Emma Wise, Courtney Weatherford, Amy E. Hulme   +4 more
doaj   +1 more source

A Vibrio cholerae viral satellite maximizes its spread and inhibits phage by remodeling hijacked phage coat proteins into small capsids

eLife
Phage satellites commonly remodel capsids they hijack from the phages they parasitize, but only a few mechanisms regulating the change in capsid size have been reported.
Caroline M Boyd, Sundharraman Subramanian, Drew T Dunham, Kristin N Parent, Kimberley D Seed   +4 more
doaj   +1 more source

Phylogeny and Immunoreactivity of Norovirus GII.P16-GII.2, Japan, Winter 2016–17

Emerging Infectious Diseases, 2018
During the 2016–17 winter season in Japan, human norovirus GII.P16-GII.2 strains (2016 strains) caused large outbreaks of acute gastroenteritis. Phylogenetic analyses suggested that the 2016 strains derived from the GII.2 strains detected during 2010–12.
Koo Nagasawa, Yuki Matsushima, Takumi Motoya, Fuminori Mizukoshi, Yo Ueki, Naomi Sakon, Koichi Murakami, Tomomi Shimizu, Nobuhiko Okabe, Noriko Nagata, Komei Shirabe, Hiroto Shinomiya, Wataru Suzuki, Makoto Kuroda, Tsuyoshi Sekizuka, Akihide Ryo, Kiyotaka Fujita, Kazunori Oishi, Kazuhiko Katayama, Hirokazu Kimura   +19 more
doaj   +1 more source

Structural Analysis of Retrovirus Assembly and Maturation

Viruses, 2021
Retroviruses have a very complex and tightly controlled life cycle which has been studied intensely for decades. After a virus enters the cell, it reverse-transcribes its genome, which is then integrated into the host genome, and subsequently all ...
Anna-Sophia Krebs, Luiza M. Mendonça, Peijun Zhang   +2 more
doaj   +1 more source