Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis
eLife, 2018 Uncoating of the metastable HIV-1 capsid is a tightly regulated disassembly process required for release of the viral cDNA prior to nuclear import. To understand the intrinsic capsid disassembly pathway and how it can be modulated, we have developed a ...
Chantal L. Márquez +10 more
semanticscholar +1 more source
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
Nature, 2016 During the early stages of infection, the HIV-1 capsid protects viral components from cytosolic sensors and nucleases such as cGAS and TREX, respectively, while allowing access to nucleotides for efficient reverse transcription.
D. Jacques +5 more
semanticscholar +1 more source
Statistical analysis of sizes and shapes of virus capsids and their resulting elastic properties
, 2013 From the analysis of sizes of approximately 130 small icosahedral viruses we find that there is a typical structural capsid protein, having a mean diameter of 5 nm and a mean thickness of 3 nm, with more than two thirds of the analyzed capsid proteins ...
Bozic, Anze Losdorfer +2 more
core +1 more source
The Impact of Capsid Proteins on Virus Removal and Inactivation During Water Treatment Processes [PDF]
, 2015 This study examined the effect of the amino acid composition of protein capsids on virus inactivation using ultraviolet (UV) irradiation and titanium dioxide photocatalysis, and physical removal via enhanced coagulation using ferric chloride.
Abbaszadegan, Morteza A. +3 more
core +3 more sources
Inhibitors of the HIV-1 capsid, a target of opportunity
Current Opinion in HIV and AIDS, 2018 Purpose of review To summarize recent advances in the discovery of chemical inhibitors targeting the HIV capsid and research on their mechanisms of action. Recent findings HIV infection is critically dependent on functions of the viral capsid.
Stephanie K. Carnes +2 more
semanticscholar +1 more source
Assessment of the cross-protective capability of recombinant capsid proteins derived from pig, rat, and avian hepatitis E viruses (HEV) against challenge with a genotype 3 HEV in pigs [PDF]
, 2012 Hepatitis E virus (HEV), the causative agent of hepatitis E, is primarily transmitted via the fecal-oral route through contaminated water supplies, although many sporadic cases of hepatitis E are transmitted zoonotically via direct contact with infected ...
Córdoba, Laura +5 more
core +1 more source
Exposure to wild-type AAV drives distinct capsid immunity profiles in humans
Journal of Clinical Investigation, 2018 Recombinant adeno-associated virus (AAV) vectors have been broadly adopted as a gene delivery tool in clinical trials, owing to their high efficiency of transduction of several host tissues and their low immunogenicity. However, a considerable proportion
K. Kuranda +9 more
semanticscholar +1 more source
Fine Structure of Viral dsDNA Encapsidation
, 2019 In vivo configurations of dsDNA of bacteriophage viruses in a capsid are known to form hexagonal chromonic liquid crystal phases. This article studies the liquid crystal ordering of viral dsDNA in an icosahedral capsid, combining the chromonic model with
Arsuaga, Javier +4 more
core +1 more source
Mechanisms of kinetic trapping in self-assembly and phase transformation [PDF]
, 2011 In self-assembly processes, kinetic trapping effects often hinder the formation of thermodynamically stable ordered states. In a model of viral capsid assembly and in the phase transformation of a lattice gas, we show how simulations in a self-assembling
Baxter R. J. +4 more
core +2 more sources
eLife, 2018 The hepatitis B virus capsid represents a promising therapeutic target. Experiments suggest the capsid must be flexible to function; however, capsid structure and dynamics have not been thoroughly characterized in the absence of icosahedral symmetry ...
Jodi A. Hadden +5 more
semanticscholar +1 more source