Results 41 to 50 of about 298,386 (364)
Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR
Nature Structural & Molecular Biology, 2020 HIV-1 capsid plays multiple key roles in viral replication, and inhibition of capsid assembly is an attractive target for therapeutic intervention. Here, we report the atomic-resolution structure of capsid protein (CA) tubes, determined by magic-angle ...
Manman Lu +9 more
semanticscholar +1 more source
Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]
, 2019 Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Balogun, Rilwan +9 more
core +2 more sources
Hepatitis A Virus Capsid Structure [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 Hepatitis A virus (HAV) has been enigmatic, evading detailed structural analysis for many years. Its recently determined high-resolution structure revealed an angular surface without the indentations often characteristic of receptor-binding sites. The viral protein 1 (VP1) β-barrel shows no sign of a pocket factor and the amino terminus of VP2 displays
Stuart, D +4 more
openaire +3 more sources
Viruses, 2020 Capsid-like particles (CLPs) are multimeric, repetitive assemblies of recombinant viral capsid proteins, which are highly immunogenic due to their structural similarity to wild-type viruses.
Kara-Lee Aves +2 more
doaj +1 more source
TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
Nature Communications, 2020 The tripartite-motif protein, TRIM5α, is an innate immune sensor that potently restricts retrovirus infection by binding to human immunodeficiency virus capsids.
A. Yu +5 more
semanticscholar +1 more source
Capsids and Genomes of Jumbo-Sized Bacteriophages Reveal the Evolutionary Reach of the HK97 Fold
mBio, 2017 Large icosahedral viruses that infect bacteria represent an extreme of the coevolution of capsids and the genomes they accommodate. One subset of these large viruses is the jumbophages, tailed phages with double-stranded DNA genomes of at least 200,000 ...
Jianfei Hua +7 more
doaj +1 more source
Measuring the force ejecting DNA from phage [PDF]
, 2004 We discuss how a balance can be established between the force acting to eject DNA from viral capsids and the force resisting its entry into a colloidal suspension which mimics the host cell cytoplasm.
Castelnovo, M. +3 more
core +1 more source
Proton-Linked Dimerization of a Retroviral Capsid Protein Initiates Capsid Assembly [PDF]
Structure, 2009 In mature retroviral particles, the capsid protein (CA) forms a shell encasing the viral replication complex. Human immunodeficiency virus (HIV) CA dimerizes in solution, through its C-terminal domain (CTD), and this interaction is important for capsid assembly.
Bailey, Graham +3 more
openaire +3 more sources
mBio, 2020 HIV is the causative agent of AIDS, which has no cure. The protein shell that encases the viral genome, the capsid, is critical for HIV replication in cells at multiple steps.
Z. Zhong +11 more
semanticscholar +1 more source
Radial distribution of RNA genome packaged inside spherical viruses
, 2008 The problem of RNA genomes packaged inside spherical viruses is studied. The viral capsid is modeled as a hollowed sphere. The attraction between RNA molecules and the inner viral capsid is assumed to be non-specific and occurs at the inner capsid ...
J. Johnson +3 more
core +1 more source