Results 51 to 60 of about 216,910 (182)
DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHV. [PDF]
, 2019 Assembly of Kaposi's sarcoma-associated herpesvirus (KSHV) begins at a bacteriophage-like portal complex that nucleates formation of an icosahedral capsid with capsid-associated tegument complexes (CATCs) and facilitates translocation of an ∼150-kb dsDNA
Bi, Guo-Qiang +6 more
core
Different Outcomes of Experimental Hepatitis E Virus Infection in Diverse Mouse Strains, Wistar Rats, and Rabbits [PDF]
, 2018 Hepatitis E virus (HEV) is the causative agent of acute hepatitis E in humans in developing countries, but autochthonous cases of zoonotic genotype 3 (HEV-3) infection also occur in industrialized countries.
Dremsek, Paul +9 more
core +1 more source
The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein
mBio, 2018 Zika virus (ZIKV) is a significant global health threat, as infection has been linked to serious neurological complications, including microcephaly. Using a human stem cell-derived neural progenitor model system, we find that a critical cellular quality ...
Krystal A. Fontaine +10 more
semanticscholar +1 more source
Osmotic pressure: resisting or promoting DNA ejection from phage [PDF]
, 2008 Recent in vitro experiments have shown that DNA ejection from bacteriophage can be partially stopped by surrounding osmotic pressure when ejected DNA is digested by DNase I on the course of ejection.
Castelnovo, Martin +4 more
core +3 more sources
Physical properties of the HIV-1 capsid from all-atom molecular dynamics simulations
Nature Communications, 2017 Human immunodeficiency virus type 1 (HIV-1) infection is highly dependent on its capsid. The capsid is a large container, made of ∼1,300 proteins with altogether 4 million atoms.
J. Perilla, K. Schulten
semanticscholar +1 more source
Nature Communications, 2018 The capsids of double-stranded DNA viruses protect the viral genome from the harsh extracellular environment, while maintaining stability against the high internal pressure of packaged DNA.
N. Stone, G. Demo, E. Agnello, B. Kelch
semanticscholar +1 more source
A beta-herpesvirus with fluorescent capsids to study transport in living cells. [PDF]
, 2012 Fluorescent tagging of viral particles by genetic means enables the study of virus dynamics in living cells. However, the study of beta-herpesvirus entry and morphogenesis by this method is currently limited.
Bauerfeind, Rudolf +11 more
core +4 more sources
PF74 Reinforces the HIV-1 Capsid To Impair Reverse Transcription-Induced Uncoating
Journal of Virology, 2018 The capsid-binding small molecule PF74 inhibits HIV-1 infection at early stages and perturbs uncoating. However, the mechanism by which PF74 alters capsid stability and reduces viral infection is presently unknown.
Sanela Rankovic +3 more
semanticscholar +1 more source
Multiple Pathways in Capsid Assembly.
Journal of the American Chemical Society, 2018 For a three-dimensional structure to spontaneously self-assemble from many identical components, the steps on the pathway must be kinetically accessible.
Corinne A. Lutomski +5 more
semanticscholar +1 more source