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Structure of the herpes-simplex virus portal-vertex [PDF]
, 2018 Herpesviruses include many important human pathogens such as herpes simplex virus, cytomegalovirus, varicella-zoster virus, and the oncogenic Epstein–Barr virus and Kaposi sarcoma–associated herpesvirus.
Bhella, David +3 more
core +2 more sources
Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms [PDF]
Cell Host & Microbe, 2019 The HIV-1 capsid is an ordered protein shell that houses the viral genome during early infection. Its expansive surface consists of an ordered and interfacing array of capsid protein hexamers and pentamers that are recognized by numerous cellular proteins. Many of these proteins recognize specific, assembled capsid interfaces not present in unassembled
Brady J, Summers +7 more
openaire +2 more sources
The HIV capsid mimics karyopherin engagement of FG-nucleoporins
NatureHIV can infect non-dividing cells because the viral capsid can overcome the selective barrier of the nuclear pore complex and deliver the genome directly into the nucleus1,2. Remarkably, the intact HIV capsid is more than 1,000 times larger than the size
C. F. Dickson +12 more
semanticscholar +1 more source
Understanding Flavivirus Capsid Protein Functions: The Tip of the Iceberg
Pathogens, 2020 Flaviviruses are enveloped positive-sense single-stranded RNA arboviruses, infectious to humans and many other animals and are transmitted primarily via tick or mosquito vectors.
S. Sotcheff, Andrew L. Routh
semanticscholar +1 more source
Phylogeny and Immunoreactivity of Norovirus GII.P16-GII.2, Japan, Winter 2016–17
Emerging Infectious Diseases, 2018 During the 2016–17 winter season in Japan, human norovirus GII.P16-GII.2 strains (2016 strains) caused large outbreaks of acute gastroenteritis. Phylogenetic analyses suggested that the 2016 strains derived from the GII.2 strains detected during 2010–12.
Koo Nagasawa +19 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2022 Prescreening of participants in clinical trials that use adeno-associated virus (AAV) vectors is required to identify naive participants, as preexisting neutralizing antibodies can limit the efficacy of AAV gene therapies.
Matthew R. Gardner +6 more
doaj +1 more source
Role of Genome in the Formation of Conical Retroviral Shells
, 2016 Human immunodeficiency virus (HIV) capsid proteins spontaneously assemble around the genome into a protective protein shell called the capsid, which can take on a variety of shapes broadly classified as conical, cylindrical and irregular. The majority of
Erdemci-Tandogan, Gonca +3 more
core +2 more sources
Bacteriophages and their structural organisation [PDF]
, 2012 Viruses are extremely small infectious particles that are not visible in a light microscope, and are able to pass through fine porcelain filters. They exist in a huge variety of forms and infect practically all living systems: animals, plants ...
Orlova, Elena
core +2 more sources
Host-driven evolution of PCV2: insights into genetic diversity and adaptation
Frontiers in ImmunologyIntroductionsPorcine circovirus type 2 (PCV2) is a significant pathogen in swine, exhibiting notable genetic and phenotypic diversity. This study explores the evolutionary mechanisms influencing PCV2 variability, emphasizing the role of viral features ...
Giovanni Franzo +6 more
doaj +1 more source
HIV Capsid Inhibitors Beyond PF74
Diseases, 2019 Human immunodeficiency virus (HIV) capsid plays important roles at multiple stages of viral replication. At the initial stages, controlled uncoating (disassembly) of the capsid ensures efficient reverse transcription of the single-stranded RNA genome ...
Carole McArthur +3 more
doaj +1 more source