Results 51 to 60 of about 71,965 (172)

Statistical analysis of sizes and shapes of virus capsids and their resulting elastic properties

, 2013
From the analysis of sizes of approximately 130 small icosahedral viruses we find that there is a typical structural capsid protein, having a mean diameter of 5 nm and a mean thickness of 3 nm, with more than two thirds of the analyzed capsid proteins ...
Bozic, Anze Losdorfer, Podgornik, Rudolf, Siber, Antonio   +2 more
core   +1 more source

Micro‐ and Nano‐Bots for Infection Control

Advanced Materials, EarlyView.
This review presents a strategic vision for integrating micro‐ and nanobots in the pipeline for infection diagnosis, prevention, and treatment. To develop these robots as a practical solution for infection management, their design principles are clarified based on their propulsion mechanisms and then categorized infection management domains based on ...
Azin Rashidy Ahmady, Shadman Khan, Hong Han, Wei Gao, Zeinab Hosseinidoust, Tohid F. Didar   +5 more
wiley   +1 more source

Atomic Structure of the Human Herpesvirus 6B Capsid and Capsid-Associated Tegument Complexes [PDF]

Biophysical Journal, 2019
AbstractHuman herpesvirus 6B (HHV-6B) belongs to the β-herpesvirus subfamily of the Herpesviridae. To understand capsid assembly and capsid-tegument interactions, here we report atomic structures of HHV-6B capsid and capsid-associated tegument complex (CATC) obtained by cryoEM and sub-particle reconstruction.
Steve Jacobson, Ana L. Alvarez-Cabrera, Guo-Qiang Bi, Yanxiang Cui, Ye Mei, Wei Liu, Emily C. Leibovitch, Zihang Li, Vinay Kumar, Yibo Zhang, Yibo Zhang, Z. Hong Zhou   +11 more
openaire   +8 more sources

Structures of Capsid and Capsid-Associated Tegument Complex Inside the Epstein-Barr Virus [PDF]

Biophysical Journal, 2020
As the first discovered human cancer virus, Epstein-Barr virus (EBV) causes Burkitt's lymphoma and nasopharyngeal carcinoma. Isolating virions for determining high-resolution structures has been hindered by latency-a hallmark of EBV infection-and atomic structures are thus available only for recombinantly expressed EBV proteins.
Caiyan Wang, Caiyan Wang, Yanxiang Cui, Danyang Gong, Danyang Gong, Xinghong Dai, Xinghong Dai, Ren Sun, Guo-Qiang Bi, Z. Hong Zhou, Zihang Li, Wei Liu, Wei Liu   +12 more
openaire   +7 more sources

Mimicking Biochemical Traits with a Synthetic Lipid Nanoparticles SARS‐COV‐2 Model

Advanced Therapeutics, EarlyView.
A synthetic virus model developed using lipid nanoparticles, which incorporate encapsulated mRNA and nucleocapsid (N) protein along with surface‐conjugated spike (S) protein, mimics the characteristics of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), allowing for the advancement of diagnostic product assessment.
Ignasia Handipta Mahardika, Hyun Park, Eunjin Huh, Changyoon Baek, Shin‐Gyu Cho, Kwang‐Hwan Jung, Junhong Min, Kwanwoo Shin   +7 more
wiley   +1 more source

Three-Dimensional Localization of the Smallest Capsid Protein in the Human Cytomegalovirus Capsid [PDF]

Journal of Virology, 2005
ABSTRACT The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We used electron cryomicroscopy and antibody labeling to show that the 8-kDa SCP of human cytomegalovirus is attached only to major capsid ...
Fenyong Liu, Xuekui Yu, Pierrette Lo, Ivo Atanasov, William J. Britt, Sanket Shah, Z. Hong Zhou   +6 more
openaire   +2 more sources

The role of packaging sites in efficient and specific virus assembly

, 2015
During the lifecycle of many single-stranded RNA viruses, including many human pathogens, a protein shell called the capsid spontaneously assembles around the viral genome. Understanding the mechanisms by which capsid proteins selectively assemble around
Hagan, M. F., Perlmutter, J. D.
core   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Kinetics of viral self-assembly: the role of ss RNA antenna [PDF]

, 2007
A big class of viruses self-assemble from a large number of identical capsid proteins with long flexible N-terminal tails and ss RNA. We study the role of the strong Coulomb interaction of positive N-terminal tails with ss RNA in the kinetics of the in ...
B. I. Shklovskii, D. F. Evans, M. V. Smoluchowski, S. Campbell, S. Campbell, S. J. Flint, Tao Hu   +6 more
core   +1 more source

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source