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Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells.

Blood, 2017
Adeno-associated virus (AAV) is a replication-deficient parvovirus that is extensively used as a gene therapy vector. CD8+ T-cell responses against the AAV capsid protein can, however, affect therapeutic efficacy.
G. Rogers +12 more
semanticscholar +1 more source

Hepatitis B Virus Capsid Completion Occurs through Error Correction.

Journal of the American Chemical Society, 2017
Understanding capsid assembly is important because of its role in virus lifecycles and in applications to drug discovery and nanomaterial development.
Corinne A. Lutomski +5 more
semanticscholar +1 more source

Clinical targeting of HIV capsid protein with a long-acting small molecule

Nature, 2020
J. Link +72 more
semanticscholar +1 more source

Microglia-specific targeting by novel capsid-modified AAV6 vectors

Molecular Therapy: Methods & Clinical Development, 2016
Recombinant adeno-associated viruses (rAAV) have been widely used in gene therapy applications for central nervous system diseases. Though rAAV can efficiently target neurons and astrocytes in mouse brains, microglia, the immune cells of the brain, are ...
Awilda M. Rosario +11 more
semanticscholar +1 more source

Site-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoprotease [PDF]

, 1990
The structural proteins of Sindbis virus are translated as a polyprotein precursor that is cleaved upon translation. The capsid protein is postulated to be a serine protease that releases itself from the N terminus of the nascent polyprotein by ...
Hahn, Chang S., Strauss, James H.
core

Method for the isolation of bacteriphage T4 mutants that produce particles with giant capsids [PDF]