Results 21 to 30 of about 4,965,597 (147)

Capsid

, 2011
Capsid is a water-jet cut optiwhite glass and perspex artwork suspended in a grid-like formation by vertical nylon wires, created in an attempt to visualize a viral capsid in the process of self-assembly or ...
Rennie, Colin
core   +5 more sources

Structural basis of receptor usage by the engineered capsid AAV-PHP.eB

Molecular Therapy - Methods & Clinical Development, 2022
Adeno-associated virus serotype 9 (AAV9) is a promising gene therapy vector for treating neurodegenerative diseases due to its ability to penetrate the blood-brain barrier. PHP.eB was engineered from AAV9 by insertion of a 7-amino acid peptide and point mutation of neighboring residues, thereby enhancing potency in the central nervous system.
Seongmin Jang, Hao K. Shen, Xiaozhe Ding, Timothy F. Miles, Viviana Gradinaru   +4 more
openaire   +5 more sources

Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses

Molecular Therapy: Methods & Clinical Development, 2019
Parvoviruses are highly attractive templates for the engineering of safe, efficient, and specific gene therapy vectors, as best exemplified by adeno-associated virus (AAV).
Julia Fakhiri, Marc A. Schneider, Jens Puschhof, Megan Stanifer, Verena Schildgen, Stefan Holderbach, Yannik Voss, Jihad El Andari, Oliver Schildgen, Steeve Boulant, Michael Meister, Hans Clevers, Ziying Yan, Jianming Qiu, Dirk Grimm   +14 more
doaj   +1 more source

Chondroitin Sulfate is the Primary Receptor for a Peptide-Modified AAV That Targets Brain Vascular Endothelium In Vivo

Molecular Therapy: Nucleic Acids, 2014
Recently, we described a peptide-modified AAV2 vector (AAV-GMN) containing a capsid-displayed peptide that directs in vivo brain vascular targeting and transduction when delivered intravenously.
James C Geoghegan, Nicholas W Keiser, Anna Okulist, Inês Martins, Matthew S Wilson, Beverly L Davidson   +5 more
doaj   +1 more source

Non-canonical amino acid incorporation into AAV5 capsid enhances lung transduction in mice

Molecular Therapy: Methods & Clinical Development, 2023
Gene therapy using recombinant adeno-associated virus (rAAV) relies on safe, efficient, and precise in vivo gene delivery that is largely dependent on the AAV capsid.
Hao Chang, Ailing Du, Jun Jiang, Lingzhi Ren, Nan Liu, Xuntao Zhou, Jialing Liang, Guangping Gao, Dan Wang   +8 more
doaj   +1 more source

Capsid-Specific Antibody Responses of Domestic Pigs Immunized with Low-Virulent African swine fever virus

, 2023
Excel file contains the raw data (P/N ratios) and results of statistical analyses that were used to plot the figures outlined in the publication Tng et al.
Egle Pauletto (14720951), Joshua Hui (760051), Christopher L. Netherton (6661382), Laila Al-Adwani (14720950), Priscilla Y. L. Tng (8377884)   +4 more
core   +1 more source

Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry

Viruses, 2021
Human gene therapy has advanced from twentieth-century conception to twenty-first-century reality. The recombinant Adeno-Associated Virus (rAAV) is a major gene therapy vector. Research continues to improve rAAV safety and efficacy using a variety of AAV
Edward E. Large, Mark A. Silveria, Grant M. Zane, Onellah Weerakoon, Michael S. Chapman   +4 more
doaj   +1 more source

Adipose Tissue: An Emerging Target for Adeno-associated Viral Vectors

Molecular Therapy: Methods & Clinical Development, 2020
Adipose tissue is one of the largest organs, playing important roles in physiology and pathologies of multiple diseases. However, research related to adeno-associated virus (AAV) targeting adipose tissue has been left far behind studies carried out in ...
Rhiannon Bates, Wei Huang, Lei Cao
doaj   +1 more source

A beta-herpesvirus with fluorescent capsids to study transport in living cells. [PDF]

, 2012
Fluorescent tagging of viral particles by genetic means enables the study of virus dynamics in living cells. However, the study of beta-herpesvirus entry and morphogenesis by this method is currently limited.
Lisa Marcinowski, Marcinowski, Lisa, Ulrich H Koszinowski, Christophe Jung (152124), Jens von Einem, Gaul, Ulrike, Paul Walther, Einem, Jens von, Jens B Bosse, Paul Walther (113867), Ruzsics, Zsolt, Ulrike Gaul, Ulrich H. Koszinowski (152143), Bosse, Jens B., Zsolt Ruzsics (75383), Leonhard Popilka (152101), Leonhard Popilka, Christophe Jung, Jens B. Bosse (138966), Lisa Marcinowski (138962), Jens B. Bosse, Martina Taeglich (152115), Rudolf Bauerfeind (152093), Taeglich, Martina, Koszinowski, Ulrich H., Hannah Striebinger, Zsolt Ruzsics, Ulrike Gaul (3154), Ulrich H. Koszinowski, Jung, Christophe, Hannah Striebinger (152128), Martina Taeglich, Jens von Einem (152134), Bauerfeind, Rudolf, Striebinger, Hannah, Rudolf Bauerfeind, Walther, Paul, Popilka, Leonhard, Jung Christophe, Taeglich Martina, Bosse Jens B., Popilka Leonhard, Bauerfeind Rudolf, Marcinowski Lisa, Walther Paul, Striebinger Hannah, von Einem Jens, Koszinowski Ulrich H., Ruzsics Zsolt, Gaul Ulrike   +49 more
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The Cold Case Files of rAAV Capsid Influence on Transduction: New Leads

Viruses
Adeno-associated virus (AAV) is a prevalent vector in viral gene therapy. Given its importance, significant efforts focus on engineering the capsid residues on the exterior surface to increase cell/tissue-specific binding to cellular receptors or to ...
Sara K. Powell
doaj   +1 more source