Results 41 to 50 of about 4,965,597 (147)
Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid [PDF]
Molecular Therapy, 2016 Adeno-associated viral (AAV) vectors are currently being tested in multiple clinical trials for liver-directed gene transfer to treat the bleeding disorders hemophilia A and B and metabolic disorders. The optimal viral capsid for transduction of human hepatocytes has been under active investigation, but results across various models are inconsistent ...
Koen, Vercauteren +11 more
openaire +2 more sources
AAV capsid sites breakdown: large protein insertions impact on vector dynamics
Frontiers in Bioengineering and BiotechnologyIntroductionAdeno-associated virus (AAV) vectors are one of the most used gene delivery systems, and several capsid engineering strategies have been followed to further improve their performance.
Mariana V. Ferreira +13 more
doaj +1 more source
Design of a large-scale virus capsid model for educational use [PDF]
, 2005 Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.Includes bibliographical references (leaf 23).A foot-scale model of an icosahedral virus capsid, as opposed to a helical capsid shape, was modeled in preparation ...
Doering Heather A. (Heather Anne)
core
Synthetic approaches to construct viral capsid-like spherical nanomaterials [PDF]
, 2018 This feature article describes recent progress in synthetic strategies to construct viral capsid-like spherical nanomaterials using the self-assembly of peptides and/or proteins.
Kazunori Matsuura +6 more
core +1 more source
Molecular Therapy: Methods & Clinical DevelopmentManufacturing of adeno-associated viruses (AAV) for gene and cell therapy applications has increased significantly and spurred development of improved mammalian and insect cell-based production systems.
Yoko Marwidi +14 more
doaj +1 more source
Design and manufacturing of a physical model of an icosahedral virus capsid [PDF]
, 2004 Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004."June 2004."Includes bibliographical references (leaf 19).Viruses enclose genetic material, DNA or RNA, that are the cause of several diseases and conditions ...
Morales, Luis F. (Luis Francisco), 1982-
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Fine-Tuning Translation Kinetics Selection as the Driving Force of Codon Usage Bias in the Hepatitis A Virus Capsid [PDF]
, 2010 Hepatitis A virus (HAV), the prototype of genus Hepatovirus, has several unique biological characteristics that distinguish it from other members of the Picornaviridae family.
Pintó Solé, Rosa María +14 more
core +1 more source
Molecular Therapy: Methods & Clinical Development, 2018 Adeno-associated virus (AAV) has provided the gene therapy field with the most powerful in vivo gene delivery vector to realize safe, efficacious, and sustainable therapeutic gene expression.
Dan Wang +14 more
doaj +1 more source
Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant ‐7m8 [PDF]
Biotechnology and Bioengineering, 2016 ABSTRACTRecently, we described a modified AAV2 vector—AAV2‐7m8—having a capsid‐displayed peptide insertion of 10 amino acids with enhanced retinal transduction properties. The insertion of the peptide referred to as 7m8 is responsible for high‐level gene delivery into deep layers of the retina when virus is delivered into the eye's vitreous.
Khabou, Hanen +7 more
openaire +2 more sources
Molecular Therapy: Methods & Clinical Development, 2019 Adeno-associated virus (AAV) vectors have become one of the most widely used gene transfer tools in human gene therapy. Considerable effort is currently being focused on AAV capsid engineering strategies with the aim of developing novel variants with ...
Marti Cabanes-Creus +15 more
doaj +1 more source