VirusesThis work builds AAV-CapNet, a deep learning model integrating Fourier frequency enhancement and cross-attention fusion, to predict the infectivity of 20 AAV capsid variants across 52 cancer cell lines with a self-built multi-omics dataset of 392 ...
Junhan Dong, Zhiyun Cheng, Yong Diao
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Oligonucleotide conjugated multi-functional adeno-associated viruses
Scientific Reports, 2018 Recombinant adeno-associated viruses (AAVs) are among the most commonly used vehicles for in vivo gene delivery. However, their tropism is limited, and additionally their efficacy can be negatively affected by prevalence of neutralizing antibodies in ...
Dhruva Katrekar +4 more
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A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions [PDF]
, 2012 Herpes viruses are prevalent and well characterized human pathogens. Despite extensive study, much remains to be learned about the structure of the genome packaging and release machinery in the capsids of these large and complex double-stranded DNA ...
Rixon Frazer J. +23 more
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Engineered MS2 Virus Capsids for Cellular Display of Peptide Antigens
ACS Chemical BiologyABSTRACT Our ability to respond to emerging pandemics and pathogen resistance relies critically on our ability to build vaccines quickly and efficiently. In this report we used an efficient enzymatic oxidative coupling reaction to create a viral capsid-based vaccine platform that is modular and quickly adaptable for ...
Hannah S. Martin +4 more
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Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis
Nature Communications, 2019 The adaptor protein SHN3 suppresses new bone formation by controlling osteoblast activity. Here, the authors show that ablation of SHN3 function, either genetically or by delivering an artificial miRNA via AAV9, rescues bone loss in osteoporotic mice ...
Yeon-Suk Yang +7 more
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Reversible loading of thiol-modified curcumin in an engineered protein capsid
RSC Advances, 2017 The dodecahedral capsid formed by Aquifex aeolicus lumazine synthase (AaLS) is a promising protein scaffold for bionanotechnological applications.
Q. Guo, G. C. Thomas, K. J. Woycechowsky
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Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein [PDF]
, 1996 Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease.
Milon, Alain +13 more
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Structural and functional consequences of AAV capsid engineering [PDF]
The use of patients' own cells to fight cancer has become a focus of cancer research in recent years. The production of T cells with tumour-specific receptors, so-called chimeric antigen receptors (CARs), is a method to activate the patient's immune system by recognising the tumour.
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Rationally engineered novel AAV capsids for intra-articular gene delivery
Molecular Therapy - Methods & Clinical DevelopmentIntra-articular adeno-associated virus (AAV) gene therapy has been explored as a potential strategy for joint diseases. However, concerns of low transduction efficacy, off-target expression, and neutralizing antibodies (Nabs) still need to be addressed.
Wenjun Li +4 more
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The molecular basis of mouse adaptation by human enterovirus 71 [PDF]
, 2008 A mouse-adapted strain of human enterovirus 71 (HEV71) was selected by serial passage of a HEV71 clinical isolate (HEV71-26M) in Chinese hamster ovary (CHO) cells (CHO-26M) and in newborn BALB/c mice (MP-26M).
Chua, B.H. +4 more
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