Results 71 to 80 of about 4,965,597 (147)
Structural characterization and epitope mapping of the AAVX affinity purification ligand
Molecular Therapy: Methods & Clinical DevelopmentThe application of adeno-associated virus (AAV) vectors in human gene therapies requires reproducible and homogeneous preparations for clinical efficacy and safety.
Mario Mietzsch +5 more
doaj +1 more source
301. AAV Capsid Engineering to Improve Transduction in Retina and Brain
Molecular Therapy, 2016 Gene therapy vectors based on adeno-associated virus (AAV) are currently in clinical studies for numerous disease indications including Leber's congenital amaurosis, age-related macular degeneration, hemophilia, muscular dystrophy and Parkinson's disease. AAV vectors hold considerable promise as therapeutic agents; however there is potential to further
Jennifer Sullivan +11 more
openaire +1 more source
Journal of Biological EngineeringBackground Several treatments for genetic diseases utilizing recombinant adeno-associated viruses (AAVs) have recently gained approval. However, the development of a greater number of therapeutic AAVs is constrained by certain limitations.
Sergio Milagros +6 more
doaj +1 more source
CapBuild: a cloud-native tool for adeno-associated virus capsid engineering
Nucleic Acids ResearchAbstract Adeno-associated virus (AAV) capsid engineering is essential for advancing gene therapy but remains limited by structural complexity and computational constraints. To address these challenges, we developed CapBuild, a cloud-native web server that streamlines AAV capsid prediction, assembly and engineering.
Anne H Klein +6 more
openaire +2 more sources
Engineering a bivalent nanoparticle vaccine with PCV2 capsid protein and PRRSV epitopes
Journal of NanobiotechnologyCoinfection with multiple viruses is a common occurrence in the pig industry. Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) are two significant pathogens, with a notable prevalence of their coinfection observed in clinical settings.
Jun Ma +7 more
openaire +3 more sources
eLifeRecombinant adeno-associated viruses (rAAVs) are the predominant gene therapy vector. Several rAAV vectored therapies have achieved regulatory approval, but production of sufficient rAAV quantities remains difficult.
Nina K Jain +2 more
doaj +1 more source
Scratching the surface of RGD-directed AAV capsid engineering
Molecular Therapy, 2021 Sergei, Zolotukhin +3 more
openaire +2 more sources
Molecular Therapy: Methods & Clinical DevelopmentSystemic delivery of adeno-associated virus serotype 9 (AAV9) to the central nervous system (CNS) is insufficient due to hindrance from the tight junctions of the blood-brain barrier (BBB).
Qingkai Song +11 more
doaj +1 more source
A geometric criterion links HIV-1 capsid topography to its biophysical properties and function
Nature CommunicationsMathematical models of virus capsid structure are pillars of modern virology, aiding the understanding of viral mechanisms and the design of antiviral interventions.
Wenhan Li +4 more
doaj +1 more source
mBioRNA phages are attractive platforms for the design of programmable bioparticles, but their development has been constrained by limited knowledge of genomic sites that can tolerate sequence insertion.
Shin-Yae Choi +6 more
doaj +1 more source