Results 81 to 90 of about 4,965,597 (147)

Advances in endothelial cell targeting by AAV vectors

open access: yesActa Biochimica Polonica
Adeno-associated virus (AAV) vectors have become a cornerstone of in vivo gene delivery. However, although the endothelium is the first cellular interface encountered after systemic delivery, native AAV serotypes exhibit poor endothelial transduction ...
Milena Cichon   +3 more
doaj   +1 more source

Structural studies of Parvoviridae capsid assembly and evolution: implications for novel AAV vector design

open access: yesFrontiers in Artificial Intelligence
Adeno-associated virus (AAV) vectors have emerged as powerful tools in gene therapy, potentially treating various genetic disorders. Engineering the AAV capsids through computational methods enables the customization of these vectors to enhance their ...
Heather A. Noriega   +3 more
doaj   +1 more source

Dissecting positive selection events and immunological drives during the evolution of adeno-associated virus lineages.

open access: yesPLoS Pathogens
Adeno-associated virus (AAV) serotypes from primates are being developed and clinically used as vectors for human gene therapy. However, the evolutionary mechanism of AAV variants is far from being understood, except that genetic recombination plays an ...
Lirong Li   +16 more
doaj   +1 more source

Cell Culture Adaptive Amino Acid Substitutions in FMDV Structural Proteins: A Key Mechanism for Altered Receptor Tropism

open access: yesViruses
The foot-and-mouth disease virus is a highly contagious and economically devastating virus of cloven-hooved animals, including cattle, buffalo, sheep, and goats, causing reduced animal productivity and posing international trade restrictions. For decades,
Hassan Mushtaq   +4 more
doaj   +1 more source

Engineering Vanderbilt; Vol. 47 No. 01, 2006

open access: yes, 2006
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core  

Engineering Vanderbilt; Vol. 44 No. 02, 2003

open access: yes, 2003
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of Engineering.School of ...
Vanderbilt University. School of Engineering
core  

Plant production and immunogenic characterisation of Human papillomavirus chimaeric vaccines [PDF]

open access: yes, 2011
Includes abstract.Includes bibliographical references (leaves 153-175).Cervical cancer is primarily caused by infection with Human papillomavirus (HPV) and is a global concern, particularly in developing countries which contain ~80% of the cervical ...
Pineo, Catherine
core  

Stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids

open access: yesNature Communications
Tailed bacteriophages are one of the most numerous and diverse group of viruses. They store their genome at quasi-crystalline densities in capsids built from multiple copies of proteins adopting the HK97-fold.
Jennifer M. Podgorski   +8 more
doaj   +1 more source

Engineering Vanderbilt; Vol. 48 No. 02, 2007

open access: yes, 2007
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core  

Engineering Vanderbilt; Vol. 49 No. 01, 2008

open access: yes, 2008
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core  

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