Results 131 to 140 of about 6,660,257 (317)
Clinical Pharmacology &Therapeutics, EarlyView.Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott +7 more
wiley +1 more source
Clinical Pharmacology Quality Assurance Program for Global HIV and Co‐Infection Drug Development
Clinical Pharmacology &Therapeutics, EarlyView.When the acquired immunodeficiency syndrome emerged in the 1980s, the United States National Institutes of Health established research networks to conduct clinical trials with the pharmaceutical industry to identify effective antiretroviral therapeutics.
Robin DiFrancesco +17 more
wiley +1 more source
Spontaneous regression of equine sarcoids is an exceptional event
Equine Veterinary Journal, EarlyView.Abstract Sarcoids are benign, yet locally aggressive skin tumours that commonly affect horses and other equid species. The lesions are induced by bovine papillomavirus types 1, 2, and probably 13 in conjunction with other factors including trauma and a genetic predisposition.
Sabine Brandt
wiley +1 more source
Using computational approaches to study dengue virus capsid assembly
Computational and Mathematical Biophysics, 2019 Dengue viral capsid plays a significant role in viral life cycle of dengue, especially in vial genome protection and virus-cell fusion. Revealing mechanisms of the viral capsid protein assembly may lead to the discovery of anti-viral drugs that inhibit ...
Salas Gicela G Saucedo +7 more
doaj +1 more source
Modulation of signaling pathways by RNA virus capsid proteins
Cellular Signalling, 2008 Capsid proteins are structural components of virus particles. They are nucleic acid-binding proteins whose main recognized function is to package viral genomes into protective structures called nucleocapsids.
Matthew D. Urbanowski +2 more
semanticscholar +1 more source
L2, the minor capsid protein of papillomavirus
Virology, 2013 The capsid protein L2 plays major roles in both papillomavirus assembly and the infectious process. While L1 forms the majority of the capsid and can self-assemble into empty virus-like particles (VLPs), L2 is a minor capsid component and lacks the capacity to form VLPs. However, L2 co-assembles with L1 into VLPs, enhancing their assembly.
Wang, Joshua W., Roden, Richard B.S.
openaire +2 more sources
iNew Medicine, EarlyView.ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu +5 more
wiley +1 more source
The Merkel Cell Polyomavirus Minor Capsid Protein
PLoS Pathogens, 2013 The surface of polyomavirus virions is composed of pentameric knobs of the major capsid protein, VP1. In previously studied polyomavirus species, such as SV40, two interior capsid proteins, VP2 and VP3, emerge from the virion to play important roles during the infectious entry process.
Rachel M Schowalter, Christopher B Buck
openaire +4 more sources
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract BACKGROUND Adeno‐Associated Virus vectors are widely used in gene therapy due to their safety and efficacy. Despite the interest in their therapeutical application, AAV purification remains a significant challenge. Density gradient ultracentrifugation using cesium chloride, sucrose, or iodixanol gradients are common methods for AAV ...
Sabrina Leigheb +6 more
wiley +1 more source