Results 161 to 170 of about 6,660,257 (317)
Expression of Glycoprotein B (gB) Correlates With Poor Prognosis in Nasopharyngeal Carcinoma
Cancer Science, EarlyView.The extent of EBV lytic replication in NPC has not been fully clarified. Our study demonstrated EBV replication and release in NPC and identified a significant association between expression of the late lytic protein gB and poor prognosis. These findings suggest that late lytic gene products may contribute to tumor progression and that gB represents a ...
Shigetaka Komura +24 more
wiley +1 more source
A facile chemical strategy to synthesize precise AAV-protein conjugates for targeted gene delivery
Molecular Therapy: OncologyCurrent adeno-associated virus (AAV) gene therapies are limited by a lack of tissue-specificity, leading to toxic off-target impacts and increased therapeutic costs. More target-specific AAV vectors can offer safer and less expensive therapies.
Quan Pham +7 more
doaj +1 more source
Multiple origins of viral capsid proteins from cellular ancestors
Proceedings of the National Academy of Sciences of the United States of America, 2017 M. Krupovic, E. Koonin
semanticscholar +1 more source
Cell Proliferation, EarlyView.AAV's widespread application is currently confronting critical challenges. This study established a systematic framework of ‘natural discovery–evolutionary analysis–functional optimization’, providing a new paradigm for the development of next‐generation AAV vectors with clinical‐grade tissue specificity, low immunogenicity, and cross‐species ...
Liyu Zhu +11 more
wiley +1 more source
Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources
The FEBS Journal, EarlyView.This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani +8 more
wiley +1 more source
Haemophilia, EarlyView.ABSTRACT Introduction Valoctocogene roxaparvovec, an adeno‐associated virus (AAV)‐based gene therapy, enables endogenous factor VIII (FVIII) expression in patients with severe hemophilia A without the need for regular FVIII infusions. Long‐term follow‐up assesses durability, safety, and immune‐related challenges following gene therapy.
Kerstin Herbst +8 more
wiley +1 more source
Capsid proteins of two bovine enteroviruses [PDF]
Biochemical Journal, 1970 M D, Johnston, S J, Martin
openaire +2 more sources