Results 181 to 190 of about 1,705,592 (288)

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Membrane Expression Enhances Folding, Multimeric Structure Formation, and Immunogenicity of Viral Capsid Proteins. [PDF]

ACS Infect Dis
Cui J, Yuan F, Qin J, Jeon JH, Yun DS, Wang T, Xu R, Cao H, Tungate AA, Netherton CL, Chen J.   +10 more
europepmc   +1 more source

Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles. [PDF]

PLoS Pathog, 2022
Francis AC, Cereseto A, Singh PK, Shi J, Poeschla E, Engelman AN, Aiken C, Melikyan GB.   +7 more
europepmc   +1 more source

SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy

Movement Disorders, EarlyView.
Abstract Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of heritable neurodegenerative disorders resulting from mutations in a wide variety of genes. HSP locomotor symptoms include lower limb weakness and spasticity that arise from progressive degeneration of corticospinal axons projecting from the motor cortex to the distal ...
Emanuela Piermarini, Peter W. Baas
wiley   +1 more source

Molecular dynamics simulations reveal mechanistic insights into aptamer-induced structural rearrangements in viral capsid proteins. [PDF]

J Comput Aided Mol Des
Low CF, Ghadin N, Mohamad Jamali MA.
europepmc   +1 more source

Development of a Rapid Adeno-Associated Virus (AAV) Identity Testing Platform through Comprehensive Intact Mass Analysis of Full-Length AAV Capsid Proteins. [PDF]

J Proteome Res, 2023
Smith J, Guapo F, Strasser L, Millán-Martín S, Milian SG, Snyder RO, Bones J.   +6 more
europepmc   +1 more source

Ranavirus risk depends on host community characteristics more than the presence of Batrachochytrium dendrobatidis

Oikos, EarlyView.
Novel parasite introductions are threatening wildlife communities globally. The degree of threat depends on the ecological context, namely host community characteristics and the presence of other parasites. How these two factors interact to shape the outcomes of parasite introductions is not known. We experimentally investigated how infection following
David R. Daversa, Andy Fenton, Lola M. Brookes, Gonçalo M. Rosa, Chris Sergeant, Trenton W. J. Garner   +5 more
wiley   +1 more source

Dynamic early biomarkers predict outcomes in pediatric Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis

Pediatric Investigation, EarlyView.
This study elucidates the critical pathogenic mechanisms of pediatric Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis (EBV‐HLH), where EBV infection triggers a cytokine storm leading to immune cell hyperactivation and tissue damage. Dynamic plasma biomarkers (EBV‐DNA, ferritin, and interferon‐γ) effectively predict treatment response ...
Feifei Liu, Qing Zhang, Sitong Chen, Yunze Zhao, Dong Wang, Hongyun Lian, Honghao Ma, Tianyou Wang, Rui Zhang, Zhigang Li   +9 more
wiley   +1 more source

Capsid proteins of two bovine enteroviruses [PDF]

Biochemical Journal, 1970
M D, Johnston, S J, Martin
openaire   +2 more sources

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source