Results 1 to 10 of about 31,706 (117)

Enhancing CAR-NK persistence to unlock its full therapeutic potentials [PDF]

Frontiers in Immunology
Chimeric Antigen Receptor-Natural Killer Cell (CAR-NK) is a promising next-generation immunotherapy. Persistence of CAR-NK cell therapy is considered a key hurdle limiting its full therapeutic potential.
Ovini Amarasinghe, Ovini Amarasinghe, Ovini Amarasinghe, Heqing Ma, Cédric S. Tremblay, Cédric S. Tremblay, Cédric S. Tremblay, Sam K. P. Kung   +7 more
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eVLP-mediated CREM editing enhances cytotoxicity of bicistronic IL-15-armored CD19/BCMA dual-target CAR-NK cells [PDF]

Frontiers in Immunology
Chimeric antigen receptor (CAR)-engineered natural killer (NK) cells represent a promising platform for cancer immunotherapy; however, optimization of CAR architecture and additional engineering strategies remain necessary to improve their functional ...
Fengqin Shang, Guanlie Li, Shiting Gong, Lijiao Zhao, Bingyu Niu, Hanyi Chen, Yuchen Fu, Lijun Zhao, Jianxun Wang, Yuanyuan Shi   +9 more
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Enhanced CD33 CAR-NK cells secreting anti-CD73scFv overcome adenosine-mediated immunosuppression and improve anti-AML efficacy [PDF]

Journal for ImmunoTherapy of Cancer
Background Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with dismal outcomes, especially in relapsed/refractory settings. Chimeric antigen receptor natural killer (CAR-NK) cell therapy holds promise but is constrained by the ...
Xin Chen, Jun Wang, Lu Wang, Weiwei Chen, Xiaohong Lu, Lei Xi, Xiaohu Fan, Pengbo Ning, Sha Gong, Yingying Bao, Nan Mei, Huanming Zhang, Huaiyu Wang   +12 more
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CD38‐Specific CAR Integrated into CD38 Locus Driven by Different Promoters Causes Distinct Antitumor Activities of T and NK Cells

Advanced Science, 2023
The robust and stable expression of CD38 in T‐cell acute lymphoblastic leukemia (T‐ALL) blasts makes CD38 chimeric antigen receptor (CAR)‐T/natural killer (NK) a potential therapy for T‐ALL. However, CD38 expression in normal T/NK cells causes fratricide
Chan Liao, Yajie Wang, Yanjie Huang, Yanting Duan, Yan Liang, Jiangqing Chen, Jie Jiang, Kai Shang, Chun Zhou, Ying Gu, Nan Liu, Xun Zeng, Xiaofei Gao, Yongmin Tang, Jie Sun   +14 more
doaj   +1 more source

From CAR-T Cells to CAR-NK Cells: A Developing Immunotherapy Method for Hematological Malignancies

Frontiers in Oncology, 2021
The approval of CD19 chimeric antigen receptor (CAR)-engineered T (CAR-T) cell products in B-cell malignancies represents a breakthrough in CAR-T cell immunotherapy.
Hui Lu, Xiaoyan Zhao, Ziying Li, Yu Hu, Huafang Wang   +4 more
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NK Cells Equipped With a Chimeric Antigen Receptor That Overcomes Inhibition by HLA Class I for Adoptive Transfer of CAR-NK Cells

Frontiers in Immunology, 2022
Dominant inhibitory receptors for HLA class I (HLA-I) endow NK cells with high intrinsic responsiveness, a process termed licensing or education, but hinder their ability to kill HLA-I+ tumor cells. Cancer immunotherapy with adoptive transfer of NK cells
Xiaoxuan Zhuang, Eric O. Long
doaj   +1 more source

ENHANCED ANTI-TUMOR ACTIVITY OF CD19.CAR-NK CELLS BY INCORPORATING IL-27

Hematology, Transfusion and Cell Therapy, 2023
Autologous T-cells expressing Chimeric Antigen Receptor (CAR) have shown great efficacy against hematologic malignancies, however, severe side effects limit their clinical use.
AFB Biggi, RN Silvestre, JTC Azevedo, MC Tirapelle, KCR Malmegrim, ML Figueiredo, DT Covas, V Picanço-Castro   +7 more
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Single VHH-directed BCMA CAR-NK cells for multiple myeloma

Experimental Hematology & Oncology, 2023
Natural killer (NK) cells are promising alternatives for the production of “off-the-shelf” CAR products, posing a lower risk of cytokine release syndrome (CRS) than CAR-T cells.
Quan Ren, Yingling Zu, Hongchang Su, Qiumei Lu, Bin Xiang, Yanping Luo, Jishuai Zhang, Yongping Song   +7 more
doaj   +1 more source

Targeting B7-H3 Immune Checkpoint With Chimeric Antigen Receptor-Engineered Natural Killer Cells Exhibits Potent Cytotoxicity Against Non-Small Cell Lung Cancer

Frontiers in Pharmacology, 2020
Chimeric antigen receptor (CAR)-modified natural killer (NK) cell therapy represents a kind of promising anti-cancer treatment because CAR renders NK cells activation and recognition specificity toward tumor cells.
Shuo Yang, Shuo Yang, Bihui Cao, Guangyu Zhou, Guangyu Zhou, Lipeng Zhu, Lipeng Zhu, Lu Wang, Li Zhang, Hang Fai Kwok, Hang Fai Kwok, Zhenfeng Zhang, Qi Zhao, Qi Zhao   +13 more
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CD44v6 specific CAR-NK cells for targeted immunotherapy of head and neck squamous cell carcinoma

Frontiers in Immunology, 2023
Head and neck squamous cell carcinoma (HNSCC) is a major challenge for current therapies. CAR-T cells have shown promising results in blood cancers, however, their effectiveness against solid tumors remains a hurdle. Recently, CD44v6-directed CAR-T cells
Ioana Sonya Ciulean, Joe Fischer, Andrea Quaiser, Christoph Bach, Hinrich Abken, Uta Sandy Tretbar, Stephan Fricke, Ulrike Koehl, Ulrike Koehl, Dominik Schmiedel, Dominik Schmiedel, Thomas Grunwald   +11 more
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