Results 41 to 50 of about 832,259 (254)

Construction of anti-HER2 affibody-directed CAR-NK and its synergistic effects with doxorubicin-loaded nanodrug against HER2-positive breast cancer

Frontiers in Immunology
IntroductionChimeric antigen receptor (CAR)-engineered T or natural killer (NK) cells are a promising approach for cancer immunotherapy. The leading region of the CAR structure is generally a single-chain antibody (scFv) fragment specific for a tumor ...
Xuesong He, Xuesong He, Zhaoyuan Liang, Qing Liu, Xiaofei Zhang, Hao Liang, Runqing Jia, Wang Sheng   +7 more
doaj   +1 more source

Clinical application and prospect of immune checkpoint inhibitors for CAR-NK cell in tumor immunotherapy

Frontiers in Immunology, 2023
Chimeric antigen receptor (CAR) engineering of natural killer (NK) cells is an attractive research field in tumor immunotherapy. While CAR is genetically engineered to express certain molecules, it retains the intrinsic ability to recognize tumor cells ...
Kangdi Yang, Yuze Zhao, Guanqun Sun, Xu Zhang, Jinjin Cao, Mingcong Shao, Xijun Liang, Lina Wang   +7 more
doaj   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

CAR T cells outperform CAR NK cells in CAR-mediated effector functions in head-to-head comparison

Experimental Hematology & Oncology
Background CAR NK cells as vehicles for engineered “off-the-shelf” cellular cancer immunotherapy have attracted significant interest. Nonetheless, a comprehensive comparative assessment of the anticancer activity of CAR T cells and CAR NK cells carrying ...
Lukas Egli, Meike Kaulfuss, Juliane Mietz, Arianna Picozzi, Els Verhoeyen, Christian Münz, Obinna Chijioke   +6 more
doaj   +1 more source

Strategies for the Development of NK Cell-Based Therapies for Cancer Treatment

Cells
CAR-T cell therapy is a promising method of cancer treatment, but it has some disadvantages. These disadvantages have led scientists to explore the use of safer CAR-NK cells and new genetic modifications in order to improve the effectiveness of CAR cells.
Tatiana Budagova, Anna Efremova, Margarita Maiak, Dmitry Goldshtein   +3 more
doaj   +1 more source

Taking Lessons from CAR-T Cells and Going Beyond: Tailoring Design and Signaling for CAR-NK Cells in Cancer Therapy

Frontiers in Immunology, 2022
Cancer immunotherapies utilize the capabilities of the immune system to efficiently target malignant cells. In recent years, chimeric antigen receptor (CAR) equipped T cells showed promising results against B cell lymphomas.
Katharina Eva Ruppel, Stephan Fricke, Ulrike Köhl, Ulrike Köhl, Ulrike Köhl, Dominik Schmiedel   +5 more
doaj   +1 more source

Universal Gripper for Industrial Manipulation With Enhanced Rigid Mechanics and Self‐Adaptable Fingers

Advanced Robotics Research, EarlyView.
An enhanced universal gripper combining rigid mechanics with self‐adaptable fingers is presented for industrial automation. The novel six‐bar linkage with integrated compliant pad eliminates mechanical interference while enabling passive shape adaptation.
Muhammad Usman Khalid, Nirmal Kumar Ravikumar, Mattia Frascio, Sumanth Nagalakunta, Alessandro Seitone, Benoît Lévesque, Alessandro Zanella, Matteo Zoppi   +7 more
wiley   +1 more source

Scalable process development of NK and CAR-NK expansion in a closed bioreactor

Frontiers in Immunology
Production of large amounts of functional NK and CAR-NK cells represents one of the bottlenecks for NK-based immunotherapy. In this study, we developed a large-scale, reliable, and practicable NK and CAR-NK production using G-Rex 100M bioreactors, which ...
Xuening Wang, Maeve Elizabeth Byrne, Chang Liu, Minh Tuyet Ma, Dongfang Liu, Dongfang Liu   +5 more
doaj   +1 more source

Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV

Protein & Cell, 2017
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells contribute to the body’s immune defenses. Current chimeric antigen receptor (CAR)-modified T cell immunotherapy shows strong promise for treating various cancers and infectious diseases ...
Dongfang Liu, Shuo Tian, Kai Zhang, Wei Xiong, Ndongala Michel Lubaki, Zhiying Chen, Weidong Han   +6 more
doaj   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source