Results 41 to 50 of about 30,272 (291)

CAR-NK Cells: From Natural Basis to Design for Kill [PDF]

Frontiers in Immunology, 2021
Chimeric antigen receptors (CARs) are fusion proteins with an extracellular antigen recognition domain and numerous intracellular signaling domains that have been genetically modified. CAR-engineered T lymphocyte-based therapies have shown great success against blood cancers; however, potential fatal toxicity, such as in cytokine release syndrome, and ...
Muhammad Babar Khawar, Muhammad Babar Khawar, Muhammad Babar Khawar, Muhammad Babar Khawar, Haibo Sun, Haibo Sun   +5 more
openaire   +3 more sources

Differential loss of chromosome 11q in familial and sporadic parasympathetic paragangliomas detected by comparative genomic hybridization [PDF]

, 2001
Parasympathetic paragangliomas (PGLs) represent neuroendocrine tumors arising from chief cells in branchiomeric and intravagal paraganglia, which share several histological features with their sympathetic counterpart ...
Dannenberg, H. (Hilde), Dinjens, W.N.M. (Winand), Heitz, P.U., Komminoth, P. (Paul), Krijger, R.R. (Ronald) de, Mooi, W.J. (Wolter), Roth, J. (Joost), Saremaslani, P., Speel, E.J. (Ernst-Jan), Zhao, J. (Jinkou)   +9 more
core   +2 more sources

Systemes hamiltoniens k-symplectiques [PDF]

, 2002
We study some properties of the k−symplectic Hamiltonian systems in analogy with the well-known classical Hamiltonian systems. The integrability of k−symplectic Hamiltonian systems and the relationships with the Nambu’s statistical mechanics ...
Awane, Azzouz, Belam, Mohamed, Fikri, Sadik, Lahmouz, Mohammed, Naanani, Bouchra   +4 more
core   +2 more sources

Targeting B7-H3 Immune Checkpoint With Chimeric Antigen Receptor-Engineered Natural Killer Cells Exhibits Potent Cytotoxicity Against Non-Small Cell Lung Cancer

Frontiers in Pharmacology, 2020
Chimeric antigen receptor (CAR)-modified natural killer (NK) cell therapy represents a kind of promising anti-cancer treatment because CAR renders NK cells activation and recognition specificity toward tumor cells.
Shuo Yang, Shuo Yang, Bihui Cao, Guangyu Zhou, Guangyu Zhou, Lipeng Zhu, Lipeng Zhu, Lu Wang, Li Zhang, Hang Fai Kwok, Hang Fai Kwok, Zhenfeng Zhang, Qi Zhao, Qi Zhao   +13 more
doaj   +1 more source

Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo

Frontiers in Immunology, 2023
IntroductionNatural killer 92 (NK-92) cells are an attractive therapeutic approach as alternative chimeric antigen receptor (CAR) carriers, different from T cells, once they can be used in the allogeneic setting. The modest in vivo outcomes observed with
Renata Nacasaki Silvestre, Jiri Eitler, Jiri Eitler, Julia Teixeira Cottas de Azevedo, Mariane Cariati Tirapelle, Daianne Maciely Carvalho Fantacini, Lucas Eduardo Botelho de Souza, Kamilla Swiech, Dimas Tadeu Covas, Rodrigo T. Calado, Paola Ortiz Montero, Paola Ortiz Montero, Kelen Cristina Ribeiro Malmegrim, Kelen Cristina Ribeiro Malmegrim, Marxa L. Figueiredo, Torsten Tonn, Torsten Tonn, Torsten Tonn, Virginia Picanço-Castro   +18 more
doaj   +1 more source

Human CAR NK cells: A new non-viral method allowing high efficient transfection and strong tumor cell killing [PDF]

, 2019
CAR-NK cells may represent a valuable tool, complementary to CART cells, in adoptive immunotherapy of leukemia and solid tumors. However, gene transfer to human NK cells is a challenging task, particularly with non-virus-based techniques.
Andrea Pelosi, Biagio De Angelis, Claudia Cantoni, Concetta Quintarelli, Concetta Quintarelli, Francesca Besi, Francesca Romana Mariotti, Franco Locatelli, Lorenzo Moretta, Nicola Tumino, Paola Vacca, Tiziano Ingegnere   +11 more
core   +4 more sources

Revving up natural killer cells and cytokine-induced killer cells against hematological malignancies [PDF]

, 2015
Natural killer (NK) cells belong to innate immunity and exhibit cytolytic activity against infectious pathogens and tumor cells. NK-cell function is finely tuned by receptors that transduce inhibitory or activating signals, such as killer immunoglobulin ...
Alici, Alnabhan, Aversa, Bachanova, Bachanova, Bachanova, Benjamin, Benson, Benyunes, Berg, Berg, Bertaina, Betters, Biassoni, Biassoni, Bonanno, Bonanno, Braud, Burns, Burshtyn, Burshtyn, Caligiuri, Caligiuri, Campbell, Campbell, Cany, Carlens, Cheng, Cheng, Cho, Chouaib, Chu, Colonna, Conlon, Cooley, Cooley, Cosman, Curti, Denman, Durrieu, D’Andrea, Edinger, Escudier, Farag, Fehniger, Frei, Frohn, Fry, Fujisaki, Fujisaki, Garg, Gleason, Gleason, Glienke, Gong, Grimm, Gumperz, Guven, Hercend, Hontscha, Imai, Imamura, Introna, Introna, Introna, Iyengar, Jiang, Jiang, Jiang, Karlhofer, Karre, Kim, Kim, Klingemann, Klingemann, Klingemann, Knorr, Knorr, Koehl, Koehl, Koehl, Koepsell, Lang, Lapteva, Lee, Li, Li, Lim, Lim, Linn, Lister, Litwin, Liu, Ljunggren, Llano, Lotze, Lu, Luhm, Lundqvist, Lundqvist, Lundqvist, Mackall, Maus, McKenna, Meehan, Meyer-Monard, Miller, Miller, Miller, Miller, Miller, Oevermann, Olcese, Olioso, Parkhurst, Pende, Pende, Peragine, Perussia, Phillips, Phillips, Phillips, Pittari, Pittari, Rabinowich, Rettinger, Rizzieri, Romagne, Rosenberg, Rosenberg, Rosenberg, Rubnitz, Ruggeri, Rutella, Rutella, Rutella, Rutella, Schmeel, Schmidt-Wolf, Schmidt-Wolf, Schumm, Shah, Shaim, Shi, Shimasaki, Siegler, Soiffer, Somanchi, Somanchi, Spanholtz, Stern, Stroncek, Sutlu, Sweeney, Tam, Tam, Tam, Tanaka, Tomchuck, Tonn, Venstrom, Venstrom, Verneris, Vey, Vitale, Wagtmann, Wagtmann, Wiernik, Winter, Yan, Yang, Yoon, Yron, Zhang, Zhang   +174 more
core   +2 more sources

Multiple cancer treatment advances with CAR-NK

Highlights in Science, Engineering and Technology, 2023
In the 21st century, cancer therapy has entered the era of combination therapy. The elucidation of immune system mechanism and the further development of cell culture technology pave the way for the application of immunotherapy in cancer clinical treatment.
openaire   +1 more source

Anti-FAP CAR-NK cells as a novel targeted therapy against cervical cancer and cancer-associated fibroblasts. [PDF]

Oncoimmunology
The tumor microenvironment (TME) has a central role in many cancers, particularly by fostering an immunosuppressive milieu. Chimeric antigen receptor (CAR)-based immunotherapy displays a promising strategy to re-direct immune cells toward specific ...
Polten R, Kutle I, Stalp JL, Hachenberg J, Seyda AK, Neubert L, Kamp JC, von Kaisenberg C, Schaudien D, Hillemanns P, Klapdor R, Morgan M, Schambach A.   +12 more
europepmc   +3 more sources

Soluble factors released by peripheral blood-derived CAR-NK cells cause bystander myeloid cell activation

Frontiers in Immunology
IntroductionCAR-T cell therapy is associated with life-threatening inflammatory toxicities, partly due to the activation and secretion of inflammatory cytokines by bystander myeloid cells (BMCs).
Supreet Khanal, Alan Baer, Md Kamal Hossain, Winston Colon-Moran, Santosh Panthi, Nirjal Bhattarai   +5 more
doaj   +1 more source