Results 51 to 60 of about 30,272 (291)

Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

Journal of Hematology & Oncology, 2020
Natural killer (NK) cells are a critical component of the innate immune system. Chimeric antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding antigens, creating major opportunities in the fight against cancer.
Ahmet Yilmaz, Hanwei Cui, Michael A. Caligiuri, Jianhua Yu   +3 more
doaj   +1 more source

CAR NK Cell Therapy for T Follicular Helper Cells [PDF]

Cell Reports Medicine, 2020
T follicular helper (TFH) cells are associated with the development of both autoimmune disease and T cell malignancies. In this issue, Reighard et al.,1 describe the design of PD-L1 chimeric antigen receptor (CAR) NK cells that effectively target and eliminate TFH cells.
openaire   +4 more sources

Synergistic Effects of Cabozantinib and EGFR-Specific CAR-NK-92 Cells in Renal Cell Carcinoma

Journal of Immunology Research, 2017
The chimeric antigen receptor-modified immune effector cell (CAR-T and CAR-NK) therapies are newly developed adoptive treatments of cancers. However, their therapeutic efficacy against solid tumors is limited.
Qing Zhang, Kang Tian, Jinjing Xu, Haixu Zhang, Liantao Li, Qiang Fu, Dafei Chai, Huizhong Li, Junnian Zheng   +8 more
doaj   +1 more source

Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells [PDF]

, 2021
Immune checkpoint therapy has resulted in remarkable improvements in the outcome for certain cancers. To broaden the clinical impact of checkpoint targeting, we devised a strategy that couples targeting of the cytokine-inducible Src homology 2–containing
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core   +2 more sources

CAR NK cells for cancer retargeting

, 2018
Adaptive immunotherapy using redirected chimeric antigen receptor (CAR) T cells against leukemia has led to promising results with improved patient survival. The continuously increasing interest in those advanced gene therapy medicinal products leads to a manufacturing challenge regarding automation, process robustness, and cell storage.
Esser, Ruth, Koehl, Ulrike, Glienke, Wolfgang, Morgan, Michael, Kaiser, Andrew, Abken, Hinrich, Heuser, Michael, Aleksandrova, Krasimira, Leise, Jana, Oberschmidt, Olaf, Priesner, Christoph, Arseniev, Lubomir, Schambach, Axel, Kloess, Stephan   +13 more
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Adoptive NK Cell Therapy - a Beacon of Hope in Multiple Myeloma Treatment [PDF]

, 2023
Major advances in the treatment of multiple myeloma (MM) have been achieved by effective new agents such as proteasome inhibitors, immunomodulatory drugs, or monoclonal antibodies.
Ha Hong Pham, Je-Jung Lee, Je-Jung Lee, Manh-Cuong Vo, Son Hai Vu, Sung-Hoon Jung, Sung-Hoon Jung, Thanh Thien Le, Thao Thi Phuong Pham, Xuan-Hung Nguyen, Xuan-Hung Nguyen   +10 more
core   +1 more source

CD28 is superior to 4-1BB costimulation in generating CAR-NK cells for tumor immunotherapy

Experimental Hematology & Oncology
Chimeric antigen receptor (CAR)-NK therapy holds great potential for tumor treatment, but current CAR designs are primarily optimized for T cells, raising concerns about their suitability for NK cells. This study compared two dominant CAR designs used in
Pengchao Zhang, Xuejia Feng, Xiangyun Niu, Zhongming Liu, Minghui Li, Maoxuan Liu, Dehong Yan, Guizhong Zhang, Xiaochun Wan   +8 more
doaj   +1 more source

Precision targeting of rhabdomyosarcoma by combining primary CAR NK cells and radiotherapy. [PDF]

J Immunother Cancer
Background: Rhabdomyosarcoma (RMS) is the most common type of soft-tissue sarcoma in children, and it remains a challenging cancer with poor outcomes in high-risk and metastatic patients.
Reindl LM, Jalili L, Bexte T, Harenkamp S, Thul S, Hehlgans S, Wallenwein A, Rothweiler F, Cinatl J, Michaelis M, Bonig H, Gradhand E, Vogler M, Rödel F, Wels WS, Ullrich E.   +15 more
europepmc   +3 more sources

Taking Lessons from CAR-T Cells and Going Beyond: Tailoring Design and Signaling for CAR-NK Cells in Cancer Therapy

Frontiers in Immunology, 2022
Cancer immunotherapies utilize the capabilities of the immune system to efficiently target malignant cells. In recent years, chimeric antigen receptor (CAR) equipped T cells showed promising results against B cell lymphomas.
Katharina Eva Ruppel, Stephan Fricke, Ulrike Köhl, Ulrike Köhl, Ulrike Köhl, Dominik Schmiedel   +5 more
doaj   +1 more source