Results 61 to 70 of about 30,272 (291)

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights from a large international sicca registry

Arthritis Care &Research, Accepted Article.
Purpose The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögrens International Collaborative Clinical Alliance (SICCA) cohort. Methods Retrospective analysis examining 16 ocular symptoms (most graded 0‐4) and artificial tear (AT) use (graded 0‐3) as predictors of DED signs [abnormal ocular surface staining ...
Pragnya R Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Interleukin-21 engineering enhances CD19-specific CAR-NK cell activity against B-cell lymphoma via enriched metabolic pathways

Experimental Hematology & Oncology
Background NK cells engineered to express interleukin-15 (IL-15) and a CD19-targeted chimeric antigen receptor (CAR) have been used to treat patients with relapsed and/or refractory B cell malignances, demonstrating encouraging outcomes and favorable ...
Bailin He, Hong Chen, Jiaxu Wu, Shiqiu Qiu, Qiusui Mai, Qing Zeng, Cong Wang, Shikai Deng, Zihong Cai, Xiaoli Liu, Li Xuan, Chengyao Li, Hongsheng Zhou, Qifa Liu, Na Xu   +14 more
doaj   +1 more source

Constitutive IL-7 signaling promotes CAR-NK cell survival in the solid tumor microenvironment but impairs tumor control

Journal for ImmunoTherapy of Cancer
Background Adoptive transfer of chimeric antigen receptor (CAR)-expressing natural killer (NK) cells has demonstrated success against hematological malignancies.
Robin Parihar, Cliona M Rooney, Matthew Dysthe, Ishwar Navin, Corrine Baumgartner, Dayenne van Leeuwen, Josue Pineda   +6 more
doaj   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

CD28 Costimulation Augments CAR Signaling in NK Cells via the LCK/CD3ζ/ZAP70 Signaling Axis [PDF]

Multiple factors in the design of a chimeric antigen receptor (CAR) influence CAR T-cell activity, with costimulatory signals being a key component. Yet, the impact of costimulatory domains on the downstream signaling and subsequent functionality of CAR ...
Acharya, Sunil, Banerjee, Pinaki P, Basar, Rafet, Biederstädt, Alexander, Cha, Sophia L, Chen, Ken, Daher, May, Deyter, Gary M, Ensley, Emily, Fathi, Mohsen, Fowlkes, Natalie W, Guo, Xingliang, Jain, Antrix, Jiang, Xianli, Jiang, Xin R, Kaplan, Mecit, Khoury, Joseph D, Kim, Kun H, Kumar, Bijender, Kundu, Kiran, Li, Ping, Li, Ye, Lin, Paul, Lin, Pei, Liu, Bin, Liu, Enli, Marin, David, Melo Garcia, Luciana, Mohanty, Vakul, Montalvo, Melisa J, Muniz-Feliciano, Luis, Nunez Cortes, Ana K, Pan, Yuchen, Rafei, Hind, Raso, Maria G, Reyes-Silva, Francia, Rezvan, Ali, Rezvani, Katayoun, Roszik, Janos, Shanley, Mayra, Shpall, Elizabeth J, Shrestha, Rejeena, Solis Soto, Luisa M, Uprety, Nadima, Varadarajan, Navin, Vega, Francisco, Zhang, Chenyu   +46 more
core   +2 more sources

Células asesinas naturales con el receptor de antígeno quimérico (CAR-NK): terapia emergente contra el cáncer [PDF]

, 2021
One of the novel and effective devices against leukemia and solid tumors in adoptive immunotherapies is the use of the chimeric antigen receptor “CAR”.
Mendoza-Rincón , Jorge Flavio, Mendoza-Rincón, Jorge Flavio, Vázquez Rodríguez , Adrián, Vázquez Rodríguez, Adrián   +3 more
core   +2 more sources

Chimeric antigen receptor-natural killer cell therapy: current advancements and strategies to overcome challenges

Frontiers in Immunology
Chimeric antigen receptor-natural killer (CAR-NK) cell therapy is a novel immunotherapy targeting cancer cells via the generation of chimeric antigen receptors on NK cells which recognize specific cancer antigens. CAR-NK cell therapy is gaining attention
Jun Chang Kong, Mohammad Auwal Sa’ad, Mohammad Auwal Sa’ad, Hema Manusri Vijayan, Manickam Ravichandran, Manickam Ravichandran, Venugopal Balakrishnan, Seng Kong Tham, Gee Jun Tye   +8 more
doaj   +1 more source

CAR-NK cell therapy: a potential antiviral platform

Science Bulletin
Viral infections persist as a significant cause of morbidity and mortality worldwide. Conventional therapeutic approaches often fall short in fully eliminating viral infections, primarily due to the emergence of drug resistance. Natural killer (NK) cells, one of the important members of the innate immune system, possess potent immunosurveillance and ...
Ming-Hao, Lin, Li-Juan, Hu, Jeffrey S, Miller, Xiao-Jun, Huang, Xiang-Yu, Zhao   +4 more
openaire   +2 more sources

Universal Gripper for Industrial Manipulation With Enhanced Rigid Mechanics and Self‐Adaptable Fingers

Advanced Robotics Research, EarlyView.
An enhanced universal gripper combining rigid mechanics with self‐adaptable fingers is presented for industrial automation. The novel six‐bar linkage with integrated compliant pad eliminates mechanical interference while enabling passive shape adaptation.
Muhammad Usman Khalid, Nirmal Kumar Ravikumar, Mattia Frascio, Sumanth Nagalakunta, Alessandro Seitone, Benoît Lévesque, Alessandro Zanella, Matteo Zoppi   +7 more
wiley   +1 more source

Estrategias basadas en el receptor de antígeno quimérico de las células NK para el tratamiento del cáncer / Strategies based on chimeric antigen receptor NK cells for cancer treatment [PDF]

, 2023
Introducción: Las células asesinas naturales o células NK son una parte esencial de la inmunovigilancia tumoral. Debido a su capacidad innata para eliminar las células tumorales, las inmunoterapias contra el cáncer basadas en células NK se han ...
Acosta Castro, Yesdel, Luzardo Lorenzo, María del Carmen, Serrano Jaime, Leivys Laura   +2 more
core   +2 more sources