Results 71 to 80 of about 30,272 (291)

CAR T cells outperform CAR NK cells in CAR-mediated effector functions in head-to-head comparison

Experimental Hematology & Oncology
Background CAR NK cells as vehicles for engineered “off-the-shelf” cellular cancer immunotherapy have attracted significant interest. Nonetheless, a comprehensive comparative assessment of the anticancer activity of CAR T cells and CAR NK cells carrying ...
Lukas Egli, Meike Kaulfuss, Juliane Mietz, Arianna Picozzi, Els Verhoeyen, Christian Münz, Obinna Chijioke   +6 more
doaj   +1 more source

Clinical application and prospect of immune checkpoint inhibitors for CAR-NK cell in tumor immunotherapy

Frontiers in Immunology, 2023
Chimeric antigen receptor (CAR) engineering of natural killer (NK) cells is an attractive research field in tumor immunotherapy. While CAR is genetically engineered to express certain molecules, it retains the intrinsic ability to recognize tumor cells ...
Kangdi Yang, Yuze Zhao, Guanqun Sun, Xu Zhang, Jinjin Cao, Mingcong Shao, Xijun Liang, Lina Wang   +7 more
doaj   +1 more source

Combination of targeted pharmacotherapy and immunotherapy with anti-CD19 CAR NK cells in acute lymphoblastic leukemia. [PDF]

Hemasphere
\ua9 2025 The Author(s). HemaSphere published by John Wiley & Sons Ltd on behalf of European Hematology Association.Anti-CD19 CAR NK cells may provide a promising non-HLA-restricted immune cell product and have been clinically studied primarily on ...
Kirchhoff H, Schoenherr C, Fleischer L, Schweighart EK, Esser R, Talbot SR, Schambach A, Koehl U, Heidenreich O, Eder M, Scherr M.   +10 more
europepmc   +3 more sources

Highly Efficient Generation of Transgenically Augmented CAR NK Cells Overexpressing CXCR4 [PDF]

Frontiers in Immunology, 2020
Natural killer (NK) cells are a noteworthy lymphocyte subset in cancer adoptive cell therapy. NK cells initiate innate immune responses against infections and malignancies with natural cytotoxicity, which is independent of foreign antigen recognition.
Arezoo Jamali, Arezoo Jamali, Arezoo Jamali, Jamshid Hadjati, Zahra Madjd, Zahra Madjd, Hamid Reza Mirzaei, Frederic B. Thalheimer, Shiwani Agarwal, Halvard Bonig, Halvard Bonig, Halvard Bonig, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Jessica Hartmann   +15 more
openaire   +6 more sources

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Exploiting Human NK Cells in Tumor Therapy [PDF]

, 2020
NK cells play an important role in the innate defenses against tumor growth and metastases. Human NK cell activation and function are regulated by an array of HLA class I-specific inhibitory receptors and activating receptors recognizing ligands ...
Mingari, M. C., Moretta, L., Munari, E., Pietra, G., Tumino, N., Vacca, P.   +5 more
core   +1 more source

NKG2D-CAR-transduced natural killer cells efficiently target multiple myeloma [PDF]

, 2021
CAR-T-cell therapy against MM currently shows promising results, but usually with serious toxicities. CAR-NK cells may exert less toxicity when redirected against resistant myeloma cells.
Carreño-Tarragona, Gonzalo, Córdoba, Laura, Fernández, Lucía, García-Ortiz, Almudena, Graña-Castro, Osvaldo, Lee, Dean A., Leivas, Alejandra, Martínez-López, Joaquín, Megías, Diego, Ortiz, Alejandra, Paciello, María Liz, Powell, Daniel J., Pérez Martínez, Antonio, Pérez, Manuel, Río, Paula, Sánchez-Pina, Jose, Sánchez-Vega, Laura, Valeri, Antonio   +17 more
core   +1 more source

Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV

Protein & Cell, 2017
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells contribute to the body’s immune defenses. Current chimeric antigen receptor (CAR)-modified T cell immunotherapy shows strong promise for treating various cancers and infectious diseases ...
Dongfang Liu, Shuo Tian, Kai Zhang, Wei Xiong, Ndongala Michel Lubaki, Zhiying Chen, Weidong Han   +6 more
doaj   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Radiotherapy enhances the anti-tumor effect of CAR-NK cells for hepatocellular carcinoma [PDF]

BACKGROUND: Chimeric antigen receptor (CAR)-NK cell therapy has shown remarkable clinical efficacy and safety in the treatment of hematological malignancies. However, this efficacy was limited in solid tumors owing to hostile tumor microenvironment (TME).
Chen, Ying, Dong, Xin, Guo, Yuetong, Guo, Zhaoze, Lin, Xiaotong, Ling, Jing, Liu, Zishen, Sugimura, Ryohichi, Sun, Yao, Wang, Fei, Wang, Kunyuan, Xiang, Hongjin, Xie, Guozhu, Xie, Qiankun, Zhang, Han, Zhang, Yuqin   +15 more
core   +1 more source