Results 91 to 100 of about 832,259 (254)

New Insights Into the Anconeus Epitrochlearis Muscle and Its Relationship to the Ulnar Nerve: Anatomical Study

Clinical Anatomy, EarlyView.
ABSTRACT Ulnar neuropathy due to compression at the cubital tunnel is common. However, our understanding of the relationships between this type of nerve compression and the variant anconeus epitrochlearis muscle (AEM) is poorly understood. Therefore, the present anatomical study was performed to better elucidate these relationships.
Somdeb Banerjee, Khoa Nguyen, Julia L. Bishop, Jaice E. Pujol, Jared E. Rosbrugh, Laphatrada Yurasakpong, Arada Chaiyamoon, Athikhun Suwannakhan, Aaron S. Dumont, Georgi P. Georgiev, Joe Iwanaga, R. Shane Tubbs   +11 more
wiley   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Harmonizing flow‐based quantification of CD19‐directed CAR‐T cells: Results from a multi‐center interlaboratory comparison

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract CD19‐directed CAR‐T cell therapy has become the standard of care for the treatment of relapsed/refractory LBCL, MCL, FL and BCP‐ALL. Expansion of CAR‐T cells in the peripheral blood (PB) of patients in the first weeks after infusion is an important biomarker for the prediction of therapy response and occurrence of toxicities.
Gerulf Hänel, Veit Bücklein, Carolina Berger, Anita Badbaran, Boris Fehse, Guranda Chitadze, Deniz Nogueira Gezer, Michael Hundemer, Wolfgang Kern, Sarah Klapproth, Ines Peschel‐Schaar, Christiane Siewert, Simon Völkl, Maria Xydia, Thomas Nebe, Michael Spannagl, Marion Subklewe   +16 more
wiley   +1 more source

KLRG1 silencing increases the efficacy of CAR NK cell therapy against colon cancer via SHP-2/ZAP-70/NF-κB signal pathway

Journal of Translational Medicine
Background NK cells are the core cells of the innate immune system, which can kill cancer cells non-specifically and almost do not cause immune rejection or neurotoxicity, thereby enabling broad application in immune cell therapy.
Yiran Chen, Muhammad Asad Farooq, Xinhui Hui, Yunhe Huang, Yue Hu, Min Xue, Iqra Ajmal, Yaojun Ren, Yuzhou Ji, Chen Wang, Wenzheng Jiang   +10 more
doaj   +1 more source

The effect of awns on seed yield and germination characteristics in Elymus nutans Griseb.

Grassland Research, EarlyView.
The effect of awns on seed yield. Three‐year field trials demonstrated that awns significantly regulate seed yield components and germination characteristics of Elymus nutans Griseb, laying a theoretical foundation for the breeding of high‐yielding forage varieties and seed production.
Yongsen Qiu, Yuying Zheng, Huanhuan Lu, Liuban Tang, Haoqin Liao, Wengang Xie   +5 more
wiley   +1 more source

Application and prospects of genetic engineering in CAR-NK cell therapy

Frontiers in Immunology
With the rapid advancement of genetic engineering technologies, CAR-NK cell therapy, as an emerging immunotherapeutic approach, has demonstrated significant potential.
Caidong Hu, Wenhong Lai, Bin Tian, Xi Xu, Shuiling Xie, Wenting Zhong, Huiqiang Kang, Xiaoyun Chen, Hailiang Li, Jingxin Xu, Liping Liu   +10 more
doaj   +1 more source

Craniofacial Resection for Advanced Cutaneous Squamous Cell Carcinoma: Results From the 2nd International Collaborative Case‐Series

Head &Neck, EarlyView.
ABSTRACT Background Robust outcome data for anterior skull base cutaneous squamous cell carcinoma (cSCC) are limited, particularly as emerging therapies reshape management. We evaluated survival and prognostic factors following craniofacial resection. Methods Retrospective multi‐institutional case‐series (1995–2015) of patients who underwent skull base
Michael J. C. Schachtel, Benedict J. Panizza, James J. Bowman, Catherine Barnett, Cristina Valero, Ian Ganly, Snehal G. Patel, Helena Levyn, Dauren Adilbay, Alana Eagan, Marc A. Cohen, Lillian A. Boe, Junting Zheng, Mithat Gonen, Prathamesh Pai, Paolo Castelnuovo, Fang Ju Gao, Cesare Piazza, Piero Nicolai, Luiz P. Kowalski, Ronaldo N. Toledo, Claudio Cernea, Sergio Goncalves, Dan M. Fliss, John R. de Almeida, Ian Witterick, Philippe Herman, Walter Fontanella, Gregorio Sanchez Aniceto, Alvaro Rivero Calle, Sefik Hosal, Serdar Ozer, Subramania Iyer, Richard J. Harvey, C. Rene Leemans, Jan‐Jaap Hendrickx, Marcelo Figari, Luis Boccalatte, Ken Ichi Nibu, Peter Clarke, Catherine Rennie, Yiming Zhu, Rodney J. Schlosser, Fernando L. Dias, Zoukaa Sargi, Shahzada Ahmed, Wojciech Golusinski, Se Heon Kim, Shirley Y. Su, Shaan M. Raza, Franco DeMonte, Ehab Hanna, Jatin P. Shah   +52 more
wiley   +1 more source

Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk

, 2012
Natural killer (NK) cells play a critical role in antitumor immunity, their activation being regulated through NK cell receptors. Although the endogenous ligands for these receptors are largely unknown, viral ligands have been identified. We investigated
Bateman, Andrew R, Elliott, Tim, James, Edward, Chinnery, Fay, King, Catherine A   +4 more
core   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source