Results 101 to 110 of about 832,259 (254)

CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation

Journal for ImmunoTherapy of Cancer
Background The antitumor activity of natural killer (NK) cells can be enhanced by specific targeting with therapeutic antibodies that trigger antibody-dependent cell-mediated cytotoxicity (ADCC) or by genetic engineering to express chimeric antigen ...
Torsten Tonn, Hans Klingemann, Winfried S Wels, Jiri Eitler, Natalie Wotschel, Laurent Boissel, Michael Bachmann, Wiebke Rackwitz, Venugopal Gudipati, Nivedha Murali Shankar, Anastasia Sidorenkova, Johannes B Huppa, Paola Ortiz-Montero, Corinna Opitz, Stephan R Künzel, Susanne Michen, Achim Temme, Liliana Rodrigues Loureiro, Anja Feldmann   +18 more
doaj   +1 more source

Chronic conditions associated with paediatric onset inflammatory bowel diseases: A population‐based study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective Several conditions are associated with inflammatory bowel disease (IBD), including immune‐mediated inflammatory diseases (IMIDs), extraintestinal manifestations (EIMs), and psychiatric disorders. This study aimed to describe at population‐level the comorbidities and their relative burden in paediatric‐onset IBD (pIBD).
Nicolas Richard, Ariane Leroyer, Hélène Sarter, Claire Dupont, Dominique Turck, Valérie Bertrand, Pauline Wils, Corinne Gower‐Rousseau, Guillaume Savoye, Nathalie Guillon, Delphine Ley, Mathurin Fumery, EPIMAD Study Group, R. Al Hameedi, M. Al Khatib, S. Al Turk, E. Agoute, J.M. Andre, M. Antonietti, A. Aouakli, A. Armand, L. Armengol‐Debeir, I. Aroichane, F. Assi, J.P. Aubet, E. Auxenfants, A. Avram, F. Ayafi‐Ramelot, K. Azzouzi, D. Bankovski, B. Barbry, N. Bardoux, P. Baron, A. Baudet, P. Bayart, B. Bazin, A. Bebahani, J.P. Becqwort, S. Bellati, V. Benet, H. Benali, C. Benard, C. Benguigui, E. Ben Soussan, A. Bental, I. Berkelmans, J. Bernet, K. Bernou, C. Bernou‐Dron, P. Bertot, N. Bertiaux‐Vandaële, V. Bertrand, E. Billoud, N. Biron, B. Bismuth, M. Bleuet, F. Blondel, V. Blondin, M. Bobula, P. Bohon, V. Bondjemah, E. Boniface, D. Bonkovski, P. Bonnière, E. Bonvarlet, P. Bonvarlet, A. Boruchowicz, R. Bostvironnois, M. Boualit, A. Bouazza, B. Bouche, C. Boudaillez, C. Bourgeaux, M. Bourgeois, A. Bourguet, A. Bourienne, H. Boutaleb, A. Bouthors, J. Branche, G. Bray, F. Brazier, P. Breban, M. Bridenne, H. Brihier, L. Bril, V. Brung‐Lefebvre, P. Bulois, P. Burgiere, J. Butel, J.Y. Canva, V. Canva‐Delcambre, J.P. Capron, F. Cardot, S. Carette, P. Carpentier, E. Cartier, J.F. Cassar, M. Cassagnou, J.F. Castex, P. Catala, S. Cattan, S. Catteau, B. Caujolle, G. Cayron, C. Chandelier, M. Chantre, J. Charles, T. Charneau, M. Chavance‐Thelu, A. Cheny, D. Chirita, A. Choteau, J.F. Claerbout, P.Y. Clergue, H. Coevoet, G. Cohen, R. Collet, M. Colin, J.F. Colombel, S. Coopman, L. Cordiez, J. Corvisart, A. Cortot, F. Couttenier, J.F. Crinquette, V. Crombe, I. Dadamessi, H. Daoudi, V. Dapvril, T. Davion, S. Dautreme, J. Debas, S. Decoster, N. Degrave, F. Dehont, C. Delatre, R. Delcenserie, D. Delesalle, O. Delette, T. Delgrange, L. Delhoustal, J.S. Delmotte, S. Demmane, G. Deregnaucourt, P. Descombes, J.P. Desechalliers, P. Desmet, P. Desreumaux, G. Desseaux, P. Desurmont, A. Devienne, E. Devouge, M. Devred, A. Devroux, A. Dewailly, S. Dharancy, A. Di Fiore, D. Djedir, R. Djedir, W. Doleh, Ml. Dreher‐Duwat, R. Dubois, C. Duburque, P. Ducatillon, J. Duclay, B. Ducrocq, F. Ducrot, P. Ducrotte, A. Dufilho, C. Duhamel, D. Dujardin, C. Dumant‐Forest, J.L. Dupas, F. Dupont, Y. Duranton, A. Duriez, N. Duveau, K. El Achkar, M. El Farisi, C. Elie, M.C. Elie‐Legrand, A. Elkhaki, M. Eoche, E. Essmaeel, D. Evrard, J.P. Evrard, A. Fatome, B. Filoche, L. Finet, M. Flahaut, C. Flamme, D. Foissey, P. Fournier, Mc. Foutrein‐ Comes, P. Foutrein, D. Fremond, T. Frere, M. Fumery, P. Gallais, C. Gamblin, S. Ganga, R. Gerard, G. Geslin, Y. Gheyssens, N. Ghossini, S. Ghrib, T Gilbert, B. Gillet, D. Godart, P. Godard, J.M. Godchaux, R. Godchaux, G. Goegebeur, O. Goria, F. Gottrand, P. Gower, B. Grandmaison, M. Groux, C. Guedon, L. Guerbeau, M. Gueroult‐Dero, J.F. Guillard, L. Guillem, F. Guillemot, D. Guimberd, B. Haddouche, S. Hakim, D. Hanon, V. Hautefeuille, P. Heckestweiller, G. Hecquet, J.P. Hedde, H. Hellal, P.E. Henneresse, B. Heyman, M. Heraud, S. Herve, P. Hochain, L. Houssin‐Bailly, P. Houcke, B. Huguenin, S. Iobagiu, S. Istanboli, A. Ivanovic, I. Iwanicki‐Caron, E. Janicki, M. Jarry, J. Jeu, Jp. Joly, C. Jonas, A. Jouvenet, F. Katherin, A. Kerleveo, A. Khachfe, A. Kiriakos, J. Kiriakos, O. Klein, M. Kohut, R. Kornhauser, D. Koutsomanis, Je. Laberenne, E. Lacotte, G. Laffineur, M. Lagarde, A. Lalanne, A. Lalieu, P. Lannoy, J. Lapchin, M. Laprand, D. Laude, R. Leblanc, P. Lecieux, S. Lecleire, N. Leclerc, C. Le Couteulx, J. Ledent, J. Lefebvre, P. Lefiliatre, C. Le Goffic, C. Legrand, A. Le Grix, P. Lelong, B. Leluyer, C. Lemaitre, C. Lenaerts, G. Lepeut, L. Lepileur, A. Leplat, E. Lepoutre‐Dujardin, H. Leroi, M.Y. Leroy, P. Le Roy, B. Lesage, Jp. Lesage, X. Lesage, J. Lesage, I. Lescanne‐Darchis, J. Lescut, D. Lescut, B. Leurent, P. Levy, M. Lhermie, L. Libier, A. Lion, B. Lisambert, I. Loge, F. Loire, J. Loreau, S. Louf, A. Louvet, L. Lubret, M. Luciani, D. Lucidarme, J. Lugand, O. Macaigne, D. Maetz, D. Maillard, H. Mancheron, O. Manolache, Ab. Marks‐Brunel, C. Marre, R. Marti, F. Martin, G. Martin, E. Marzloff, P. Mathurin, J. Mauillon, V. Maunoury, J.L. Maupas, Ma. Medam Djomo, C. Mechior, Z. Melki, B. Mesnard, P. Metayer, L. Methari, B. Meurisse, F. Meurisse, L. Michaud, X. Mirmaran, P. Modaine, A. Monthe, L. Morel, P.E. Mortier, E. Moulin, O. Mouterde, N. Mozziconaci, J. Mudry, M. Nachury, Md. Ngo, E. N'Guyen Khac, B. Notteghem, V. Ollevier, A. Ostyn, A. Ouraghi, B. Oussadou, D. Ouvry, B. Paillot, C. Painchart, N. Panien‐Claudot, C. Paoletti, A. Papazian, B. Parent, B. Pariente, Jc. Paris, P. Patrier, T. Paupard, B. Pauwels, M. Pauwels, E. Penninck, R. Petit, M. Piat, S. Piotte, C. Plane, B. Plouvier, E. Pollet, P. Pommelet, D. Pop, C. Pordes, G. Pouchain, P. Prades, A. Prevost, Jc. Prevost, G. Quartier, B. Quesnel, A.M. Queuniet, Jf. Quinton, A. Rabache, P. Rabelle, G. Raclot, S. Ratajczyk, D. Rault, V. Razemon, N. Reix, T. Renaut‐Vantroys, M. Revillion, G. Riachi, C. Richez, P. Robinson, J. Rodriguez, J. Roger, J.M. Roux, A. Rudelli, A. Saber, G. Savoye, P. Schlossberg, D. Sefrioui, M. Segrestin, D. Seguy, C. Seminur, M. Serin, A. Seryer, F. Sevenet, N. Shekh, J. Silvie, V. Simon, C. Spyckerelle, N. Talbodec, N. Tavernier, H. Tchandeu, A. Techy, J.L. Thelu, A. Thevenin, H. Thiebault, J. Thomas, J.M. Thorel, C. Thuillier, G. Tielman, M. Tode, J. Toisin, J. Tonnel, Jy. Touchais, P. Toumelin, Y. Touze, J.L. Tranvouez, C. Triplet, N. Triki, D. Turck, S. Uhlen, E. Vaillant, C. Valmage, D. Vanco, N. Vandaele‐Bertiaux, H. Vandamme, E. Vanderbecq, E. Vander Eecken, P. Vandermolen, P. Vandevenne, L. Vandeville, A. Vandewalle, C. Vandewalle, P. Vaneslander, J.P. Vanhoove, A. Vanrenterghem, C. Vanveuren, P. Varlet, I. Vasies, G. Verbiese, J. Verlynde, G. Vernier‐Massouille, P. Vermelle, C. Verne, P. Vezilier‐Cocq, B. Vigneron, M. Vincendet, J. Viot, Y.M. Voiment, A. Wacrenier, L. Waeghemaecker, J.Y. Wallez, M. Wantiez, F. Wartel, J. Weber, J.L. Willocquet, N. Wizla, E. Wolschies, O. Zaharia, S. Zaoui, A. Zalar, B. Zaouri, A. Zellweger, C. Ziade   +480 more
wiley   +1 more source

Novel strategies to overcome tumor immunotherapy resistance using CAR NK cells

Frontiers in Immunology
While immunotherapy faces obstacles, the emergence of chimeric antigen receptor (CAR) engineered natural killer (NK) cells is paving new ways and might become a preferred option over CAR T cells very soon.
Jun-Hui Guo, Ali Afzal, Ali Afzal, Sadia Ahmad, Ghazala Saeed, Amna Rehman, Umair Ali Khan Saddozai, Umair Ali Khan Saddozai, Lei Liu, Shi-Hao Guo, Xin-Ying Ji, Xin-Ying Ji, Muhammad Babar Khawar, Muhammad Babar Khawar, Muhammad Babar Khawar   +14 more
doaj   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Divergent on-target off-tumor effects by CAR T and CAR NK cells suggest different efficacy and safety of cell therapies

OncoImmunology
CAR-based cell therapies have shown clinical success in treating various cancers, with CAR T cell therapies entering the clinical route and CAR NK cell therapies being evaluated in early-stage clinical trials.
Katharina Schindler-Wnek, Anika Stahringer, Nadine Heimer, Ulrike Koehl, Stephan Fricke, Dominik Schmiedel   +5 more
doaj   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source

Leukoreduction filter derived NK cells offer a promising source for off the shelf CAR NK cell immunotherapy

Scientific Reports
Immunotherapy employing natural killer (NK) cells has emerged as a transformative approach to treating hematological malignancies. The reprogramming of NK cells by incorporating a chimeric antigen receptor (CAR) equipped with potent signaling domains has
Ali Moazzeni, Maryam Kheirandish, Gholamreza Khamisipour, Fatemeh Rahbarizadeh, Ali Akbar Pourfathollah   +4 more
doaj   +1 more source

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

Pediatric Investigation, EarlyView.
Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia, Jie Zheng, Meng Yuan, Hongbo He, Yibo Fan, Bin Wang, Guanghua Zhu, Jun Yang, Yanhui Luo, Lixiao Cai, Pan Zhang, Yanlong Duan, Maoquan Qin   +12 more
wiley   +1 more source