Results 121 to 130 of about 832,259 (254)

CAR-NK cells for gastrointestinal cancer immunotherapy: from bench to bedside

Molecular Cancer
Background Gastrointestinal (GI) cancers represent a significant health burden worldwide. Their incidence continues to increase, and their management remains a clinical challenge.
Xingwang Zhu, Jieyun Xue, Hongzhou Jiang, Dongwei Xue   +3 more
doaj   +1 more source

Signaling intact membrane-bound IL-15 enables potent anti-tumor activity and safety of CAR-NK cells

Frontiers in Immunology
BackgroundChimeric antigen receptor (CAR)-NK cells are a promising and safe alternative to CAR-T cells. However, the limited persistence in vivo restricts their clinical application and sustained therapeutic responses.
Xiaodi Xu, Peiyu Cao, Meng Wang, Meng Wang, Meng Wang, Yan Wan, Shuwen Sun, Yuxin Chen, Yuxin Chen, Yuxin Chen, Yilin Liu, Tong Su, Tong Su, Tong Su, Ge Gao, Ge Gao, Ge Gao, Xinze Liu, Weixiang Zhong, Xi Chen, Xiaoyuan Lu, Buze Chen, Buze Chen, Junnian Zheng, Junnian Zheng, Gang Wang, Gang Wang, Gang Wang, Huizhong Li, Huizhong Li, Huizhong Li   +30 more
doaj   +1 more source

Interface as a design choice: How the implementation of interfaces influences coordination and performance in modular systems

Strategic Management Journal, EarlyView.
Abstract Research Summary Modular systems play a central role in technological innovation. Such systems emerge when interdependencies among modules in a complex system are isolated through interfaces. While early seminal work highlighted the importance of interface design, subsequent research on modularity has largely overlooked it.
Daniel Albert, Martin Ganco
wiley   +1 more source

CAR-NK Cell Therapy: A Transformative Approach to Overcoming Oncological Challenges

Biomolecules
The use of chimeric antigen receptor (CAR) in natural killer (NK) cells for cancer therapy is gaining momentum, marking a significant shift in cancer treatment.
Wangshu Li, Xiuying Wang, Xu Zhang, Aziz ur Rehman Aziz, Daqing Wang   +4 more
doaj   +1 more source

Data_Sheet_2_Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing.PDF

, 2019
CAR-NK cells may represent a valuable tool, complementary to CAR-T cells, in adoptive immunotherapy of leukemia and solid tumors. However, gene transfer to human NK cells is a challenging task, particularly with non-virus-based techniques.
Tiziano Ingegnere (6647330), Francesca Romana Mariotti (6647333), Andrea Pelosi (4912558), Lorenzo Moretta (247081), Franco Locatelli (130400), Francesca Besi (768381), Paola Vacca (377695), Biagio De Angelis (6647336), Nicola Tumino (650284), Claudia Cantoni (326729), Concetta Quintarelli (6627311)   +10 more
core   +1 more source

Strategic search: Adaptation of internal fit and market positioning under competition

Strategic Management Journal, EarlyView.
Abstract Research Summary Firms seeking competitive advantage need both internal fit and a distinctive market position, yet strategy research says little about how the search for the two is related. We develop a model of strategic search that integrates an NK landscape with differentiated Cournot competition, allowing a firm's position to shape both ...
Gianluigi Giustiziero, Aseem Kaul, Dirk Martignoni   +2 more
wiley   +1 more source

CAR NK cell production from human cord blood NK progenitor cells is enhanced by stimulation of the IL-15 receptor

Cancer Immunology, Immunotherapy
Cord blood (CB)-derived chimeric antigen receptor (CAR) natural killer (NK) cells have demonstrated significant antitumor efficacy. We recently reported that CB-derived CAR NK cells predominantly originate from CD7+CD56−CD34−HLA-DR−Lin− NK cell ...
Yosuke Kogue, Shunya Ikeda, Yuto Maehara, Ryuhei Kawamoto, Makiko Suga, Shuhei Kida, Kumi Shibata, Kazuhito Tsutsumi, Hiraku Murakami, Emiko Mizuta, Yo Mizutani, Yuta Yamaguchi, Daisuke Okuzaki, Naoki Hosen   +13 more
doaj   +1 more source

Normal‐Mode‐Aware Augmented Kernel One‐Class SVM for Heterogeneous Normality Modeling

IEEJ Transactions on Electrical and Electronic Engineering, EarlyView.
Despite the rapid advances in anomaly detection, many existing methods assume that normal data are homogeneous and can be modeled by a single one‐class boundary. However, in many practical scenarios, normal data are heterogeneous and consist of multiple latent modes, making conventional latent‐space kernels insufficient to characterize normality.
Wenqian Yu, Jiaying Wu, Jinglu Hu
wiley   +1 more source

The Efficacy of CD19/CD22 Bispecific Chimeric Antigen Receptor (CAR) in NK-92 Cells, αβ T Cells, and γδ T Cells for B Cell Lymphoma (BCL) Cells

, 2023
Background: Anti-CD19 chimeric antigen receptor (CAR) T cell therapy is effective in the treatment of relapsed or refractory aggressive B-cell lymphomas, but it can induce antigen-escape such as CD19low or CD19- malignant B cells and relapse.
한민아
core  

Aligning Transnational due Diligence: The EU Deforestation Regulation and Brazil's Fragmented Beef Governance

Global Policy, EarlyView.
ABSTRACT Transnational due diligence regulations, such as the European Union Regulation on Deforestation‐Free Products (EUDR), are reshaping sustainability governance by transforming voluntary norms into binding global rules. Yet, their effectiveness depends on how well they align with domestic governance systems and on the power asymmetries that ...
John James Loomis, Khalid Nadvi, José Antônio Puppim de Oliveira   +2 more
wiley   +1 more source