Results 111 to 120 of about 832,259 (254)

Precision immunomodulation for pediatric hemophagocytic lymphohistiocytosis in intensive care

Pediatric Investigation, EarlyView.
This review presents a bedside framework for recognizing pediatric hemophagocytic lymphohistiocytosis and cytokine storm, stabilizing organ dysfunction, identifying the underlying phenotype, selecting targeted immunomodulation, considering extracorporeal adjuncts, and reassessing response within 24–72 h. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH)
Weerapong Lilitwat, Prakreeti Bhandari
wiley   +1 more source

Combinatorial immunotherapy with anti-ROR1 CAR NK cells and an IL-21 secreting oncolytic virus against neuroblastoma

Children with recurrent/metastatic neuroblastoma (NB) have a dismal survival (
Yaya Chu, Jessica Ayala-Cuesta, Mendelowitz, Alyssa S., Klose, Kayleigh, Alyssa S. Mendelowitz, Foley, Keira, Dean A. Lee, Ayala-Cuesta, Jessica, Lee, Dean A., Timothy P. Cripe, Luo, Wen, Keira Foley, Kayleigh Klose, Cassady, Kevin A., Mehmet F. Ozkaynak, Chu, Yaya, Cairo, Mitchell S., Mitchell S. Cairo, Cripe, Timothy P., Wen Luo, Ozkaynak, Mehmet F., Uksha Saini, Saini, Uksha, Meijuan Tian, Kevin A. Cassady, Tian, Meijuan   +25 more
core   +1 more source

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Rheumatology &Autoimmunity, EarlyView.
The Treg‐stromal cell axis as a central regulator of tissue repair and immune tolerance. Under physiological conditions, bidirectional communication between Tregs and stromal cells—mediated by cell‐surface molecular contacts, anti‐inflammatory cytokines, and extracellular vesicles—orchestrates inflammation resolution, immune tolerance, and complete ...
Peiyan Zhang, Rongyuan Gao, Zhaohui Zheng   +2 more
wiley   +1 more source

UAV‐Based Precision Seed Dropping for Automated Reforestation

Journal of Field Robotics, EarlyView.
ABSTRACT Wildfires and deforestation pose significant threats to forest ecosystems, motivating scalable methods for reforestation beyond labor‐intensive cultivation of native forest seedlings in nurseries. To enable large‐scale direct seeding of native species, this paper presents the design, analysis, and field evaluation of a UAV‐based seed‐dropping ...
Qi Rui Lee, Henrik Hesse, Khuanphirom Naruangsri, Worayut Takaew, Stephen Elliott, Dinesh Bhatia   +5 more
wiley   +1 more source

Engineering CAR-NK Cells with Enhanced Persistence and Functionality for Cancer Immunotherapy

Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of hematologic malignancies, but its application remains limited by manufacturing constraints, toxicity, and antigen escape.
Muyasarah, Kamila
core   +3 more sources

Strong capacity of differentiated PD-L1 CAR-modified UCB-CD34+ cells and PD-L1 CAR-modified UCB-CD34+-derived NK cells in killing target cells and restoration of the anti-tumor function of PD-1-high exhausted T Cells

Stem Cell Research & Therapy
Background Using natural killer (NK) cells to treat hematopoietic and solid tumors has great promise. Despite their availability from peripheral blood and cord blood, stem cell-derived NK cells provide an “off-the-shelf” solution.
Farhoodeh Ghaedrahmati, Vajihe Akbari, Hooria Seyedhosseini-Ghaheh, Nafiseh Esmaeil   +3 more
doaj   +1 more source

CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells

, 2015
Glioblastoma (GB) remains the most aggressive primary brain malignancy. Adoptive transfer of chimeric antigen receptor (CAR)-modified immune cells has emerged as a promising anti-cancer approach, yet the potential utility of CAR-engineered natural killer
Kaur, Balveen, Chu, Jianhong, Grandi, Paola, Wang, Qi-En, Yu, Jianhua, Han, Jianfeng, Cohen, Justus B., Victor, Aaron, He, Xiaoming, Glorioso III, Joseph C., Zhang, Jianying, Keung Chan, Wing, Wang, Youwei, Caligiuri, Michael A., Meisen, Walter H., Nakano, Ichiro, Chiocca, E., Kim, Sung-hak   +17 more
core   +1 more source

Sustainability in Business Process Management: Research Landscape and Theoretical Implications

Sustainable Development, EarlyView.
ABSTRACT Sustainability in Business Process Management (BPM) is a growing priority for organisations seeking to balance operational efficiency with environmental and social responsibility. Although research highlights the benefits of integrating sustainability into BPM—such as regulatory compliance, cost reduction and corporate reputation enhancement ...
Silvia Dallavalle, João Henrique Paulino Pires Eustachio, Walter Leal Filho, Maria Laura Salomão David, Alexandre Rodrigues Cajuela, Lara Letícia Donegá Carreira   +5 more
wiley   +1 more source

In-depth comparative characterization identifies scalable CD123-CAR-NK cells as promising strategy to combat AML

Acute myeloid leukemia (AML) is a hematological malignancy characterized by immense heterogeneity, not only between patients but also within malignant populations, leading to limited curative outcomes.
Claudia Lengerke, Sabine Müller, Juliane Schlueter, Lea Kramer, Fenja Gierschek, Christina Kuhn, Saskia Rudat, Ulrike Köhl, Julia Kostyra, Conny Blumert, Sabine Huenecke, Nina Möker, Claudia Cappel, Irene Gonzalez-Menendez, Philipp Wendel, Ningyu LI, Olaf Penack, Jan Kuska, Hadeer Mohamed Rasheed, Jan-Henning Klusmann, Evelyn Ullrich, Leticia Quintanilla-Martinez, Kristin Reiche, Dennis Löffler, Congcong Zhang   +24 more
core   +1 more source

Cell‐Based Micro/Nanorobots: From Living Carriers to Living Therapeutic Specialists

SmartBot, EarlyView.
Cell‐based micro/nanorobots integrate evolutionarily acquired biological intelligence with engineered capabilities, offering new opportunities for precision medicine in vivo. However, the complex physiological environments of different organs pose significant challenges to their clinical translation.
Junfeng Wu, Zhaoyu Zhang, Ke Xu, Enkuo Li, Yuting Cui, Yuting Zhou, Huanyu Zhou, Beipei Zhang, Shuai Jiang, Xiaodong Wang, Jialin Jiang, Lianqing Liu, Niandong Jiao   +12 more
wiley   +1 more source