Engineering CD5-targeting CAR-NK cells from peripheral blood for the treatment of CD5-positive hematological malignancies. [PDF]
Lin H +6 more
europepmc +1 more source
A short‐term flood, implemented in a field experiment with sprinkler irrigation in maize production systems, increased soil moisture levels and reduced autoclaved citrate extractable protein, an indicator of soil biological health that reflects organically bound soil nitrogen, and also corresponded to greater differential abundance of soil bacterial ...
Katherine Naasko +7 more
wiley +1 more source
Anti-Mesothelin CAR-NK cells as a novel targeted therapy against cervical cancer. [PDF]
Kutle I +16 more
europepmc +1 more source
Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging
T cells are the most dynamically altered immune population in the aged liver. Accumulation of CD8+ Tex in aged livers. Spatial enrichment of CD8+ Tex in the portal vein zone. PP hepatocytes promote T cell exhaustion via Lpin1. T cell exhaustion correlates with liver disease progression.
Jiahua Lu +7 more
wiley +1 more source
CAR-NK cells with dual targeting of PD-L1 and MICA/B in lung cancer tumor models. [PDF]
Zhi L +8 more
europepmc +1 more source
From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki +2 more
wiley +1 more source
A structural, genetic and clinical comparison of CAR-T cells and CAR-NK cells: companions or competitors? [PDF]
Andrea AE +4 more
europepmc +1 more source
Signatures of Radiation‐Induced Stress and Putative Selection on Immune Targets in Chornobyl Wolves
ABSTRACT Investigating the physiological and evolutionary consequences of contaminant exposure in wild populations is critical for understanding long‐term ecological impacts of anthropogenic change. However, how and why species persist, even thrive, in highly contaminated regions in the absence of humans remains a topic of much debate.
Cara N. Love +9 more
wiley +1 more source
CD28 signaling domain boosts persistence and <i>in vivo</i> anti-tumor activity of stem cell-derived CD19-CAR-NK cells. [PDF]
Kok N +9 more
europepmc +1 more source
Schematic summary of the machine learning‐driven analysis for high‐yield cucumber architecture. This study employs machine learning methods to analyze key shoot and root traits, building a predictive model for yield. The analysis identifies an optimal plant architecture: a compact and sturdy shoot structure, combined with a narrow yet larger‐diameter ...
Cuifang Zhu +8 more
wiley +1 more source

