Results 251 to 260 of about 812,191 (301)

Editorial: Achilles heel of CAR T-cell therapy. [PDF]

open access: yesFront Immunol
Chiriva-Internati M, Grizzi F.
europepmc   +1 more source

Boosting CAR T-cell efficacy by blocking proteasomal degradation of membrane antigens.

open access: yesBlood
Rieger L   +32 more
europepmc   +1 more source

An NK-like CAR T cell transition in CAR T cell dysfunction

open access: yesCell, 2021
Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in hematological malignancies but remains ineffective in solid tumors, due in part to CAR T cell exhaustion in the solid tumor microenvironment. To study dysfunction of mesothelin-redirected CAR T cells in pancreatic cancer, we establish a robust model of continuous antigen ...
M Angela Aznar   +2 more
exaly   +4 more sources

CAR T Cells

Neurosurgery Clinics of North America, 2021
Chimeric antigen receptor T (CAR-T) cells, an immunotherapy that demonstrates marked success in treatment of hematologic malignancies, are an emergent therapeutic for patients with glioblastoma (GBM). GBM CAR-T trials have focused on targeting well-characterized antigens in the pathogenesis of GBM.
Thilan, Tudor   +2 more
openaire   +2 more sources

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