Results 11 to 20 of about 16,333 (208)

Combined Effects of Intermittent Hypoxia and Amyloid Beta on Hippocampal Activity, Its Cholinergic Modulation, and Memory. [PDF]

open access: yesHippocampus
ABSTRACT Obstructive sleep apnea (OSA), characterized by repetitive upper airway obstruction, leads to chronic intermittent hypoxia (cIH) and induces cognitive and neuronal network disruptions similar to those observed in Alzheimer's disease (AD). These pathologies are often presented together in the elderly and share some pathophysiological mechanisms.
Pinedo-Vargas L   +4 more
europepmc   +2 more sources

Light-Activated Pharmacological Tools for Exploring the Cholinergic System. [PDF]

open access: yesMed Res Rev
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Colleoni A   +5 more
europepmc   +2 more sources

KV7 Channel Expression and Function Within Rat Mesenteric Endothelial Cells

open access: yesFrontiers in Physiology, 2020
Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs).
Samuel N. Baldwin   +4 more
doaj   +1 more source

Water Drinking Behavior Associated with Aversive Arousal in Rats: An Integrative Approach

open access: yesBrain Sciences, 2022
Cholinergic muscarinic stimulation of vast areas of the limbic brain induced a well-documented polydipsia in laboratory rats. This excessive water-drinking behavior has not received any convincing biological and physiological interpretation for the last ...
Stefan M. Brudzynski
doaj   +1 more source

The Muscarinic Acetylcholine M2 Receptor-Induced Nitration of p190A by eNOS Increases RhoA Activity in Cardiac Myocytes

open access: yesCells, 2023
p190RhoGAP, which exists in two paralogs, p190RhoGAP-A (p190A) and p190RhoGAP-B (p190B), is a GTPase activating protein (GAP) contributing to the regulation of the cellular activity of RhoGTPases.
Magdolna K. Levay   +3 more
doaj   +1 more source

Medial Septum Modulates Cellular Response Induced in Hippocampus on Microinjection of Cholinergic Agonists into Hypothalamic Lateral Supramammillary Nucleus

open access: yesFrontiers in Neuroanatomy, 2017
Cholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and ...
Mohammed Z. Ariffin   +4 more
doaj   +1 more source

Muscarinic Receptors as Targets for Metronomic Therapy in Ovarian Cancer

open access: yesDüzce Tıp Fakültesi Dergisi, 2023
Aim: In this study, the effects of muscarinic acetylcholine receptor (mAChR) agonist carbachol on the proliferation of cisplatin-resistant (A2780cis) and cisplatin-free (SKOV-3) ovarian cancer cell line were for the first time investigated to further ...
Fatma Söylemez   +1 more
doaj   +1 more source

Intracellular stored calcium plays a minor role in Gq-coupled receptor-mediated contraction in rat airway smooth muscle

open access: yesLife Sciences, Medicine and Biomedicine, 2018
The general notion of activation of Gq-protein coupled receptors involves the mobilisation of stored and extracellular calcium and leads to smooth muscle tissue contraction.
Kayatri Govindaraju   +3 more
doaj   +1 more source

Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes. [PDF]

open access: yesPLoS ONE, 2014
Inositol 1,4,5-trisphosphate (IP3) evokes release of Ca2+ from the endoplasmic reticulum (ER), but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles.
Cristina I López Sanjurjo   +2 more
doaj   +1 more source

In vitro Comparison of the Intrinsic Activity of Functional Antagonism between β-agonists and Spasmogens in the Guinea-pig Tracheal Muscle

open access: yesAllergology International, 2005
Background: The bronchodilating action of β-agonists depends on the tone of airway smooth muscle or on spasmogen. To estimate the precise intrinsic activity of β-agonists, relaxation responses should be examined on maximally contracted airway smooth ...
Yuichiro Kamikawa, Naomi Takayama
doaj   +1 more source

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