Results 11 to 20 of about 45,565 (301)

Gastrin-Releasing Peptide Facilitates Cholinergically Mediated Contractions of the Mouse Gastric Fundus. [PDF]

open access: yesPharmacol Res Perspect
Gastrin‐releasing peptide concentration‐dependently potentiates the cholinergic contractions of mouse gastric fundus circular muscle evoked by electric field stimulation. ABSTRACT Gastrin‐releasing peptide (GRP) and neuromedin B (NMB) are found in the stomach's myenteric plexus and muscular layers.
Currò D, Makwana R, Sanger GJ.
europepmc   +2 more sources

Phytochemical Analysis, Antispasmodic, Myorelaxant, and Antioxidant Effect of Dysphania ambrosioides (L.) Mosyakin and Clemants Flower Hydroethanolic Extracts and Its Chloroform and Ethyl Acetate Fractions

open access: yesMolecules, 2021
Dysphania ambrosioides (L.) Mosyakin and Clemants is an annual or ephemeral perennial herb used traditionally in the Mediterranean region in folk medicine to treat various illnesses, including those related to the digestive system.
Fahd Kandsi   +9 more
doaj   +1 more source

A Cholinergic Synaptically Triggered Event Participates in the Generation of Persistent Activity Necessary for Eye Fixation [PDF]

open access: yes, 2004
An exciting topic regarding integrative properties of the nervous system is how transient motor commands or brief sensory stimuli are able to evoke persistent neuronal changes, mainly as a sustained, tonic action potential firing.
Alvarado, Juan Carlos   +5 more
core   +4 more sources

KV7 Channel Expression and Function Within Rat Mesenteric Endothelial Cells

open access: yesFrontiers in Physiology, 2020
Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs).
Samuel N. Baldwin   +4 more
doaj   +1 more source

Water Drinking Behavior Associated with Aversive Arousal in Rats: An Integrative Approach

open access: yesBrain Sciences, 2022
Cholinergic muscarinic stimulation of vast areas of the limbic brain induced a well-documented polydipsia in laboratory rats. This excessive water-drinking behavior has not received any convincing biological and physiological interpretation for the last ...
Stefan M. Brudzynski
doaj   +1 more source

Resilient Hippocampal Gamma Rhythmogenesis and Parvalbumin-Expressing Interneuron Function Before and After Plaque Burden in 5xFAD Alzheimer’s Disease Model

open access: yesFrontiers in Synaptic Neuroscience, 2022
Recent studies have implicated impaired Parvalbumin Fast-Spiking Interneuron (PVIN) function as a precipitating factor underlying abnormalities in network synchrony, oscillatory rhythms, and cognition associated with Alzheimer’s disease (AD).
Connie A. Mackenzie-Gray Scott   +9 more
doaj   +1 more source

Muscarinic Receptors as Targets for Metronomic Therapy in Ovarian Cancer

open access: yesDüzce Tıp Fakültesi Dergisi, 2023
Aim: In this study, the effects of muscarinic acetylcholine receptor (mAChR) agonist carbachol on the proliferation of cisplatin-resistant (A2780cis) and cisplatin-free (SKOV-3) ovarian cancer cell line were for the first time investigated to further ...
Fatma Söylemez   +1 more
doaj   +1 more source

Intracellular stored calcium plays a minor role in Gq-coupled receptor-mediated contraction in rat airway smooth muscle

open access: yesLife Sciences, Medicine and Biomedicine, 2018
The general notion of activation of Gq-protein coupled receptors involves the mobilisation of stored and extracellular calcium and leads to smooth muscle tissue contraction.
Kayatri Govindaraju   +3 more
doaj   +1 more source

Carbachol increases intracellular free calcium concentrations in human granulosa-lutein cells [PDF]

open access: yes, 1992
We investigated whether the stimulation of human granulosa-lutein cells with muscarinic and nicotinic receptor agonists can cause increases in intracellular free calcium (Ca2+), using Fura-2 microfluorimetry.
Föhr, K. J.   +3 more
core   +1 more source

Clinical outcomes of combined versus separate carbachol and brimonidine drops in correcting presbyopia

open access: yesEye and Vision, 2016
BackgroundTo test and compare in a masked fashion the efficacy of using a parasympathomimetic drug (3% carbachol) and an alpha-2 agonist (0.2% brimonidine) in both combined and separate forms to create optically beneficial miosis to pharmacologically ...
A. Abdelkader, H. Kaufman
semanticscholar   +1 more source

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