Results 11 to 20 of about 16,333 (208)
Combined Effects of Intermittent Hypoxia and Amyloid Beta on Hippocampal Activity, Its Cholinergic Modulation, and Memory. [PDF]
HippocampusABSTRACT Obstructive sleep apnea (OSA), characterized by repetitive upper airway obstruction, leads to chronic intermittent hypoxia (cIH) and induces cognitive and neuronal network disruptions similar to those observed in Alzheimer's disease (AD). These pathologies are often presented together in the elderly and share some pathophysiological mechanisms.
Pinedo-Vargas L +4 more
europepmc +2 more sources
Light-Activated Pharmacological Tools for Exploring the Cholinergic System. [PDF]
Med Res RevABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Colleoni A +5 more
europepmc +2 more sources
KV7 Channel Expression and Function Within Rat Mesenteric Endothelial Cells
Frontiers in Physiology, 2020 Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs).
Samuel N. Baldwin +4 more
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Water Drinking Behavior Associated with Aversive Arousal in Rats: An Integrative Approach
Brain Sciences, 2022 Cholinergic muscarinic stimulation of vast areas of the limbic brain induced a well-documented polydipsia in laboratory rats. This excessive water-drinking behavior has not received any convincing biological and physiological interpretation for the last ...
Stefan M. Brudzynski
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Cells, 2023 p190RhoGAP, which exists in two paralogs, p190RhoGAP-A (p190A) and p190RhoGAP-B (p190B), is a GTPase activating protein (GAP) contributing to the regulation of the cellular activity of RhoGTPases.
Magdolna K. Levay +3 more
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Frontiers in Neuroanatomy, 2017 Cholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and ...
Mohammed Z. Ariffin +4 more
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Muscarinic Receptors as Targets for Metronomic Therapy in Ovarian Cancer
Düzce Tıp Fakültesi Dergisi, 2023 Aim: In this study, the effects of muscarinic acetylcholine receptor (mAChR) agonist carbachol on the proliferation of cisplatin-resistant (A2780cis) and cisplatin-free (SKOV-3) ovarian cancer cell line were for the first time investigated to further ...
Fatma Söylemez +1 more
doaj +1 more source
Life Sciences, Medicine and Biomedicine, 2018 The general notion of activation of Gq-protein coupled receptors involves the mobilisation of stored and extracellular calcium and leads to smooth muscle tissue contraction.
Kayatri Govindaraju +3 more
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Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes. [PDF]
PLoS ONE, 2014 Inositol 1,4,5-trisphosphate (IP3) evokes release of Ca2+ from the endoplasmic reticulum (ER), but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles.
Cristina I López Sanjurjo +2 more
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Allergology International, 2005 Background: The bronchodilating action of β-agonists depends on the tone of airway smooth muscle or on spasmogen. To estimate the precise intrinsic activity of β-agonists, relaxation responses should be examined on maximally contracted airway smooth ...
Yuichiro Kamikawa, Naomi Takayama
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