Frontiers in Neuroanatomy, 2017 Cholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and ...
Mohammed Z. Ariffin +4 more
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Cells, 2023 p190RhoGAP, which exists in two paralogs, p190RhoGAP-A (p190A) and p190RhoGAP-B (p190B), is a GTPase activating protein (GAP) contributing to the regulation of the cellular activity of RhoGTPases.
Magdolna K. Levay +3 more
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M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes [PDF]
, 2017 Morphine inefficiency to induce the internalization of mu opioid (MOP) receptors observed in numerous experimental models constitutes a paradigm of G-protein coupled receptor (GPCR) functional selectivity.
Alvarez-Curto, Elisa +2 more
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Carbachol and Nicotine in Prefrontal Cortex Have Differential Effects on Sleep-Wake States
Frontiers in Neuroscience, 2020 The role of the brainstem cholinergic system in the regulation of sleep-wake states has been studied extensively but relatively little is known about the role of cholinergic mechanisms in prefrontal cortex in the regulation of sleep-wake states.
Anjum Parkar +11 more
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Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET [PDF]
, 2010 Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the ...
Alvarez-Curto, Elisa +3 more
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Allergology International, 2005 Background: The bronchodilating action of β-agonists depends on the tone of airway smooth muscle or on spasmogen. To estimate the precise intrinsic activity of β-agonists, relaxation responses should be examined on maximally contracted airway smooth ...
Yuichiro Kamikawa, Naomi Takayama
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Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes. [PDF]
PLoS ONE, 2014 Inositol 1,4,5-trisphosphate (IP3) evokes release of Ca2+ from the endoplasmic reticulum (ER), but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles.
Cristina I López Sanjurjo +2 more
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Multiple Residues in the Second Extracellular Loop Are Critical for M3 Muscarinic Acetylcholine Receptor Activation [PDF]
, 2007 Recent studies suggest that the second extracellular loop (o2 loop) of bovine rhodopsin and other class I G protein-coupled receptors (GPCRs) targeted by biogenic amine ligands folds deeply into the transmembrane receptor core where the binding of cis ...
Kim, Soo-Kyung +3 more
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Carbachol inhibits TNF-α-induced endothelial barrier dysfunction through alpha 7 nicotinic receptors
Acta Pharmacologica Sinica, 2010 Aim:To test whether carbachol can influence endothelial barrier dysfunction induced by tumor necrosis factor (TNF)-α and whether the alpha 7 nicotinic receptor can mediate this process.Methods:Rat cardiac microvascular endothelial cells were exposed to ...
Yu-Zhen Li +4 more
semanticscholar +1 more source
Regulation of CCK-induced ERK1/2 activation by PKC epsilon in rat pancreatic acinar cells
AIMS Molecular Science, 2017 The extracellular signal-regulated kinase ERK1/2 is activated in pancreatic acinar cells by cholecystokinin (CCK) and other secretagogues with this activation mediated primarily by protein kinase C (PKC).
Chenwei Li, John A. Williams
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