Results 51 to 60 of about 43,661 (255)

Curcuma longa extract exerts a myorelaxant effect on the ileum and colon in a mouse experimental colitis model, independent of the anti-inflammatory effect. [PDF]

PLoS ONE, 2012
BACKGROUND: Curcuma has long been used as an anti-inflammatory agent in inflammatory bowel disease. Since gastrointestinal motility is impaired in inflammatory states, the aim of this work was to evaluate if Curcuma Longa had any effect on intestinal ...
Rita Aldini, Roberta Budriesi, Giulia Roda, Matteo Micucci, Pierfranco Ioan, Antonia D'Errico-Grigioni, Alessandro Sartini, Elena Guidetti, Margherita Marocchi, Monica Cevenini, Francesca Rosini, Marco Montagnani, Alberto Chiarini, Giuseppe Mazzella   +13 more
doaj   +1 more source

Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol

Brazilian Journal of Medical and Biological Research, 1997
We investigated the effects of losartan, an AT1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist).
W.A. Saad, A.C. Luiz, L.A.A. Camargo, J.E.N. Silveira, S. Fóglia, J.V. Menani, William A. Saad   +6 more
doaj   +1 more source

Local carbachol application induces oral microvascular recruitment and improves gastric tissue oxygenation during hemorrhagic shock in dogs

Frontiers in Immunology
IntroductionHemorrhagic shock is characterized by derangements of the gastrointestinal microcirculation. Topical therapy with nitroglycerine or iloprost improves gastric tissue oxygenation but not regional perfusion, probably due to precapillary ...
Stefan Hof, Lara Lingens, Marius Michels, Carsten Marcus, Anne Kuebart, Anna Herminghaus, Inge Bauer, Olaf Picker, Richard Truse, Christian Vollmer   +9 more
doaj   +1 more source

TRPV4 Complexes With the Na+/Ca2+ Exchanger and IP3 Receptor 1 to Regulate Local Intracellular Calcium and Tracheal Tension in Mice

Frontiers in Physiology, 2019
Intracellular Ca2+ is critical for regulating airway smooth muscle (ASM) tension. A rapid rise in the intracellular Ca2+ concentration ([Ca2+]i) of ASM cells is crucial for modulating the intensity and length of the ASM contraction.
Jie Zhang, Jie Zhang, Yuan Wei, Suwen Bai, Shenggang Ding, Huiwen Gao, Sheng Yin, Sheng Yin, Shuo Chen, Jinsen Lu, Haoran Wang, Yonggang Shen, Bing Shen, Juan Du   +13 more
doaj   +1 more source

Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]

, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Clapp, LH, Cui, Y, Giblin, JP, Quinn, KV, Tinker, A   +4 more
core   +1 more source

Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of G(i)- and G(q)-mediated signaling [PDF]

, 1999
RGS proteins (Regulators of G protein Signaling) are a recently discovered family of proteins that accelerate the GTPase activity of heterotrimeric G protein α subunits of the i, q, and 12 classes.
Backlund, Peter S., Caron, Joan M., Chen, Ching-Kang, Druey, Kirk M., Jones, Teresa L. Z., Ugur, Ozlem   +5 more
core   +1 more source

Diabetes-induced alterations in urothelium function:Enhanced ATP release and nerve-evoked contractions in the streptozotocin rat bladder [PDF]

, 2018
Up to 80% of patients with diabetes mellitus develop lower urinary tract complications, most commonly diabetic bladder dysfunction (DBD). The aim of this study was to investigate the impact of diabetes on the function of the inner bladder lining ...
Apodaca, Birder, Birder, Brown, Chaiyaprasithi, Cheng, Cheng, Cho, Daly, Daneshgari, Daneshgari, Daneshgari, Dunning-Davies, Eika, Ferguson, Fovaeus, Frimodt-Moller, Golbidi, Gomez, Hanna-Mitchell, Hanna-Mitchell, Hawthorn, Kang, Knight, Kolta, Kumar, Kumar, Lai, Langdale, Liu, Liu, Longhurst, Malmgren, Mumtaz, Munoz, Munoz, Mustafa, Nirmal, Pinna, Ren, Sadananda, Sellers, Silva-Ramos, Smith, Stella, Sun, Tammela, Templeman, Vahabi, Vahabi, Vlaskovska, Wang, Xiao, Xiao, Yoshida, Yoshimura, Zhao   +56 more
core   +1 more source

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

Changes in Anxiety-Related Behaviors, Voiding Patterns, and Urinary Bladder Contractile Properties in Male Mice Exposed to Water Avoidance Stress for 1 Day and 28 Days

Biology
Repeated water avoidance stress (WAS) for 10 days is a common rodent model to mimic the effect of chronic psychological stress on urinary bladder dysfunction.
Sarunnuch Sattayachiti, Panida Chumpong, Seree Niyomdecha, Dania Cheaha, Nipaporn Konthapakdee   +4 more
doaj   +1 more source

Transactivation of the Epidermal Growth Factor Receptor in Colonic Epithelial Cells by Carbachol Requires Extracellular Release of Transforming Growth Factor-α*

Journal of Biological Chemistry, 2002
We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, and Src kinase activation.
D. Mccole, S. Keely, R. Coffey, K. Barrett   +3 more
semanticscholar   +1 more source