Results 51 to 60 of about 16,333 (208)

Pharmacological basis for the medicinal use of cardamom in asthma

Bangladesh Journal of Pharmacology, 2011
Cardamom (Elettaria cardamomum) is widely used in folk medicine for the treatment of asthma. This study describes its airways relaxant potential, with elucidation of possible underlying mechanism.
Arif ullah Khan, Qaiser Jabeen Khan, Anwar Hassan Gilani   +2 more
doaj   +1 more source

Gαq signalling from endosomes: A new conundrum

British Journal of Pharmacology, Volume 182, Issue 14, Page 3068-3089, July 2025.
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Biomimetic Design of Biocompatible Neural Probes for Deep Brain Signal Monitoring and Stimulation: Super Static Interface for Immune Response‐Enhanced Contact

Advanced Functional Materials, Volume 35, Issue 23, June 5, 2025.
Ultrathin, flexible neural probes are developed with an innovative, biomimetic design incorporating brain tissue‐compatible materials. The material system employs biomolecule‐based encapsulation agents to mitigate inflammatory responses, as demonstrated through comprehensive in vitro and in vivo studies.
Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Seon Yeong Chae, Min Jae Kim, Ki Jun Yu, Hwa Kyoung Shin, Suck Won Hong   +7 more
wiley   +1 more source

Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways

Advances in Pharmacological Sciences, 2014
Objective. The objective of this study was to find out the possible antiulcer mechanism of action of Eremomastax speciosa. Method. Carbachol- and histamine-induced hypersecretion, associated with the pylorus ligation technique, were used in rats. Gastric
Amang André Perfusion, Paul V. Tan, Nkwengoua Ernestine, Nyasse Barthélemy   +3 more
doaj   +1 more source

Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK

Advanced Science, Volume 12, Issue 23, June 20, 2025.
PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou, Junliang Jiang, Yunqin Li, Xinyi Ding, Qiuping Tong, Ying Shi, Lei Xiao, Ling Chen   +7 more
wiley   +1 more source

The Role of Muscarinic Receptors on spasmolytic Activity of Hydroalcohlic Extract of Parsley(petroselinum crispum)Seed in Adult Male Rat's Ileum [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2016
Background: because of the side effects of chemical drugs, using plant drugs was considered during recent decades. Based on previous studies, various concentrations of plant extracts can reduce ileum contraction caused by KCl and carbachol. Therefore, in
Raede Tavalaee, Ahmad Ali Moazedi, Mohammadkazem Gharib Naseri, Mohammadreza Akhond   +3 more
doaj  

Antispasmodic and bronchorelaxant activities of Salsola imbricata are mediated through dual Ca+2 antagonistic and β-adrenergic agonistic effects

Pharmaceutical Biology, 2017
Context: Salsola imbricata Forssk. (Chenopodiaceae) has folkloric repute for the treatment of various gastrointestinal and respiratory ailments. Objective: The present study investigates spasmolytic and bronchorelaxant effects of S. imbricata.
Naveed Aslam, Khalid Hussain Janbaz
doaj   +1 more source

Inhibition of Female and Male Human Detrusor Smooth Muscle Contraction by the Rac Inhibitors EHT1864 and NSC23766

Frontiers in Pharmacology, 2020
IntroductionLower urinary tract symptoms (LUTS) due to overactive bladder (OAB) are caused by spontaneous detrusor contractions. Medical treatment with muscarinic receptor antagonists or β3-adrenoceptor agonists aims to inhibit detrusor contractions, but
Bingsheng Li, Qingfeng Yu, Ruixiao Wang, Christian Gratzke, Christian Gratzke, Xiaolong Wang, Annabel Spek, Annika Herlemann, Alexander Tamalunas, Frank Strittmatter, Raphaela Waidelich, Christian G. Stief, Martin Hennenberg   +12 more
doaj   +1 more source

Gender-differences of in vitro colonic motility after chemo- and radiotherapy in humans

BMC Pharmacology and Toxicology, 2018
Background The aim of the present in vitro study was to investigate, in different genders, motor responses in surgical colonic specimens from patients with rectal cancer undergoing and not undergoing chemotherapy with capecitabine and radiotherapy ...
Maria Antonietta Maselli, Antonia Ignazzi, Francesco Pezzolla, Annunziata Scirocco, Dionigi Lorusso, Fabrizio De Ponti, Carola Severi   +6 more
doaj   +1 more source