Results 71 to 80 of about 43,661 (255)

The Role of Endogenous Human Trp4 in Regulating Carbachol-induced Calcium Oscillations in HEK-293 Cells*

open access: yesJournal of Biological Chemistry, 2002
We utilized 2-aminoethyoxydiphenyl borane, an agent that blocks store-operated Ca2+ entry, as well as an antisense approach to characterize endogenous Ca2+ entry pathways in HEK-293 cells.
Xiaoyan Wu   +3 more
semanticscholar   +1 more source

A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart [PDF]

open access: yes, 1982
These experiments employ the photoisomerizable compound, 3,3'-bis- [alpha-(trimethylammonium)methyl]azobenzene (Bis-Q), to study the response to muscarinic agents in frog myocardium. In homogenates from the heart, trans-Bis-Q blocks the binding of [3H]-N-
Birdsall, Nigel J. M.   +5 more
core   +1 more source

Glial cells in the heart: Implications for their roles in health and disease

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya   +2 more
wiley   +1 more source

C-fos expression in the pons and medulla of the cat during carbachol- induced active sleep

open access: yesJournal of Neuroscience, 1993
Microinjection of carbachol into the rostral pontine tegmentum of the cat induces a state that is comparable to naturally occurring active (REM, rapid eye movement) sleep.
J. Yamuy   +3 more
semanticscholar   +1 more source

An integrated platform for 2‐D and 3‐D optical and electrical mapping of arrhythmias in Langendorff‐perfused rabbit hearts

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Integrated multimodal platform for panoramic cardiac mapping in isolated heart experiments. On the left, an image of the experimental setup during data acquisition showing a Langendorff‐perfused rabbit heart surrounded by three optical cameras (CAM A, B and C) positioned 120° apart, each coupled with high‐power LEDs for panoramic
Jimena Siles   +8 more
wiley   +1 more source

Inhibitory Effect of the Phosphoinositide 3-Kinase Inhibitor LY294002 on Muscarinic Acetylcholine Receptor-Induced Calcium Entry in PC12h Cells

open access: yesJournal of Pharmacological Sciences, 2007
Phosphoinositide-3 kinase (PI3K) and phospholipase C (PLC) utilize the same phosphoinositides as substrates to produce different signaling molecules. These enzymes are activated by a similar set of cell signaling mechanisms, i.e., tyrosine kinases and G ...
Mitsuhiro Morita   +3 more
doaj   +1 more source

Combination of lipopolysaccharide and hypoxia-ischemia attenuates cholinergic anti-inflammatory effect in newborn rat brains

open access: yesClinical and Experimental Obstetrics & Gynecology, 2020
Aim: Pharmacologic parasympathetic nerve stimulation markedly reduces brain damage in a newborn rat model of hypoxia-ischemia (HI). Our aim is to determine whether a brain-protective effect can be achieved by parasympathetic nerve stimulation even with ...
S. Furukawa, L. Yang, H. Sameshima
doaj   +1 more source

Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons [PDF]

open access: yes, 1990
A method for clamping cytosolic free Ca2+ ([Ca2+]i) in cultures of rat sympathetic neurons at or below resting levels for several days was devised to determine whether Ca2+ signals are required for neurite outgrowth from neurons that depend on Nerve ...
Murrell, R D   +3 more
core   +2 more sources

Distinct Roles of SLC26A3 and CFTR in Surface pH Regulation and Bicarbonate Secretion in Human Intestinal Epithelium

open access: yesActa Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Mahdi Amiri, Azam Salari, Ursula Seidler
wiley   +1 more source

Possible approaches to reproduction of endothelial dysfunction. searching for the optimal model

open access: yesФармакокинетика и Фармакодинамика
Purpose of the study. Search for an optimal approach to developing a translational model of endothelial dysfunction (ED).Materials and methods. The experiments were carried out on 58 white male rats, which were randomized into 8 groups: 1st (n = 6 ...
I. B. Tsorin   +5 more
doaj   +1 more source

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