Results 51 to 60 of about 849,115 (259)

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

Organism-specific Trends in Carbapenem-resistant Enterobacterales Infections in a Cohort of Hospitalized Patients, 2012–2022

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Carbapenem-resistant Enterobacterales (CRE) infections are an urgent public health threat. An estimated 12,700 CRE (including E. coli, Klebsiella spp., and Enterobacter spp.) infections occurred in the United States in 2020.
Mohammed Khan, Hannah Wolford, Natalie McCarthy, Babatunde Olubajo, Jonathan Bishop, James Baggs, Joseph Lutgring, Sujan Reddy, Maroya Walters   +8 more
doaj   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Concurrent Resistance to Carbapenem and Colistin Among Enterobacteriaceae Recovered From Human and Animal Sources in Nigeria Is Associated With Multiple Genetic Mechanisms

Frontiers in Microbiology, 2021
Resistance to last resort drugs such as carbapenem and colistin is a serious global health threat. This study investigated carbapenem and colistin resistance in 583 non-duplicate Enterobacteriaceae isolates utilizing phenotypic methods and whole genome ...
Emmanuel O. Ngbede, Folasade Adekanmbi, Anil Poudel, Anwar Kalalah, Patrick Kelly, Yi Yang, Andrew M. Adamu, Salem T. Daniel, Alex A. Adikwu, Chinedu A. Akwuobu, Paul O. Abba, Levi M. Mamfe, Nanven A. Maurice, Mohammed I. Adah, Olivia Lockyear, Patrick Butaye, Patrick Butaye, Chengming Wang   +17 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Mechanisms of carbapenem resistance: exploring the complexities [PDF]

JAC-Antimicrobial Resistance, 2019
Graphical Abstract.
openaire   +2 more sources

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

Prevalence of bla OXA-48 and other carbapenemase encoding genes among carbapenem-resistant Pseudomonas aeruginosa clinical isolates in Egypt

BMC Infectious Diseases
Background Resistance to carbapenem, the last line of treatment for gram-negative bacterial infections has been increasing globally and becoming a public health threat.
Wedad M. Abdelraheem, Doaa Elzaeem Ismail, Safaa S. Hammad   +2 more
doaj   +1 more source

Prevalence, Risk Factors, and Outcome of Carbapenem-resistant Acinetobacter Infections in a Community Hospital in Madinah, Saudi Arabia

Saudi Journal of Medicine and Medical Sciences
Background Acinetobacter is a Gram-negative bacterium that causes nosocomial infections, increasing healthcare costs, patient morbidity, and mortality.
Zied Gaifer, Raneem Fallatah, Alhanouf Alanazi, Raghad Alfagi, Lina Alharbi, Haitham Osman   +5 more
doaj   +1 more source

Characterisation of carbapenem-resistant Gram-negative organisms from clinical specimens in Yola, Nigeria

Journal of Global Antimicrobial Resistance, 2020
Objectives: This study aimed to identify carbapenem-resistant Gram-negative bacteria from clinical specimens of patients in Yola, Nigeria. Methods: Routine clinical specimens were screened for the presence of carbapenem-resistant Gram-negative bacteria ...
Shuwaram A. Shettima, Isabella A. Tickler, Caitlin M. dela Cruz, Fred C. Tenover   +3 more
doaj   +1 more source