Results 41 to 50 of about 48,910 (207)

IN VITRO EFFICACY OF CICLOPIROX AGAINST CARBAPENEM RESISTANT ENTEROBACTERIACEAE

Pakistan Armed Forces Medical Journal, 2021
Objective: To determine the in vitro efficacy of Ciclopirox against Carbapenem Resistant Enterobacteriaceae by determining its minimum inhibitory concentration by micro agar dilution method. Study Design: Quasi experimental study.
Maliha Ansari, Hassan Ikram, Nadia Saad, Aaminah Hanif, Aiza Sadia, Qazi Ikram Ullah   +5 more
doaj  

Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes [PDF]

Diagnostic Microbiology and Infectious Disease, 2013
The emergence of carbapenem resistance in Enterobacteriaceae is an important threat to global health. Reported outcomes of infections with carbapenem-resistant Enterobacteriaceae (CRE) are poor. Very few options remain for the treatment of these virulent organisms.
David, van Duin, Keith S, Kaye, Elizabeth A, Neuner, Robert A, Bonomo   +3 more
openaire   +2 more sources

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Association between antibiotic consumption and the rate of carbapenem-resistant Gram-negative bacteria from China based on 153 tertiary hospitals data in 2014

Antimicrobial Resistance and Infection Control, 2018
Background This study aimed to investigate the relationship between the rate of carbapenem-resistant Gram-negative bacteria and antibiotic consumption intensity in 153 tertiary hospitals from China in 2014.
Ping Yang, Yunbo Chen, Saiping Jiang, Ping Shen, Xiaoyang Lu, Yonghong Xiao   +5 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Organism-specific Trends in Carbapenem-resistant Enterobacterales Infections in a Cohort of Hospitalized Patients, 2012–2022

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Carbapenem-resistant Enterobacterales (CRE) infections are an urgent public health threat. An estimated 12,700 CRE (including E. coli, Klebsiella spp., and Enterobacter spp.) infections occurred in the United States in 2020.
Mohammed Khan, Hannah Wolford, Natalie McCarthy, Babatunde Olubajo, Jonathan Bishop, James Baggs, Joseph Lutgring, Sujan Reddy, Maroya Walters   +8 more
doaj   +1 more source

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

Concurrent Resistance to Carbapenem and Colistin Among Enterobacteriaceae Recovered From Human and Animal Sources in Nigeria Is Associated With Multiple Genetic Mechanisms

Frontiers in Microbiology, 2021
Resistance to last resort drugs such as carbapenem and colistin is a serious global health threat. This study investigated carbapenem and colistin resistance in 583 non-duplicate Enterobacteriaceae isolates utilizing phenotypic methods and whole genome ...
Emmanuel O. Ngbede, Folasade Adekanmbi, Anil Poudel, Anwar Kalalah, Patrick Kelly, Yi Yang, Andrew M. Adamu, Salem T. Daniel, Alex A. Adikwu, Chinedu A. Akwuobu, Paul O. Abba, Levi M. Mamfe, Nanven A. Maurice, Mohammed I. Adah, Olivia Lockyear, Patrick Butaye, Patrick Butaye, Chengming Wang   +17 more
doaj   +1 more source

Mechanisms of carbapenem resistance: exploring the complexities [PDF]

JAC-Antimicrobial Resistance, 2019
Graphical Abstract.
openaire   +2 more sources

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source