Results 41 to 50 of about 862,573 (173)

Structural compatibility between β‐lactams and substrate binding pockets of IMP‐1 and NDM‐1 determines the substrate spectrum

Bulletin of the Korean Chemical Society, EarlyView.
Chemical structures of three β‐lactam classes and the substrate‐binding pockets (SBPs) of B1 metallo‐β‐lactamases (MBLs) were compared. Structural compatibility between β‐lactams and MBL SBPs correlates with enzymatic activity, providing insights into the substrate spectrum of MBLs and β‐lactam resistance.
Kiwoong Kwak, Jiwon Yun, Donghyun Lee, Byung‐Jin Lee, Juyeon Lim, Jung Hun Lee, Sang Hee Lee, Soon Young Shin, Lin‐Woo Kang   +8 more
wiley   +1 more source

Prevalence of bla OXA-48 and other carbapenemase encoding genes among carbapenem-resistant Pseudomonas aeruginosa clinical isolates in Egypt

BMC Infectious Diseases
Background Resistance to carbapenem, the last line of treatment for gram-negative bacterial infections has been increasing globally and becoming a public health threat.
Wedad M. Abdelraheem, Doaa Elzaeem Ismail, Safaa S. Hammad   +2 more
doaj   +1 more source

Prevalence, Risk Factors, and Outcome of Carbapenem-resistant Acinetobacter Infections in a Community Hospital in Madinah, Saudi Arabia

Saudi Journal of Medicine and Medical Sciences
Background Acinetobacter is a Gram-negative bacterium that causes nosocomial infections, increasing healthcare costs, patient morbidity, and mortality.
Zied Gaifer, Raneem Fallatah, Alhanouf Alanazi, Raghad Alfagi, Lina Alharbi, Haitham Osman   +5 more
doaj   +1 more source

Characterisation of carbapenem-resistant Gram-negative organisms from clinical specimens in Yola, Nigeria

Journal of Global Antimicrobial Resistance, 2020
Objectives: This study aimed to identify carbapenem-resistant Gram-negative bacteria from clinical specimens of patients in Yola, Nigeria. Methods: Routine clinical specimens were screened for the presence of carbapenem-resistant Gram-negative bacteria ...
Shuwaram A. Shettima, Isabella A. Tickler, Caitlin M. dela Cruz, Fred C. Tenover   +3 more
doaj   +1 more source

Thirteen years of environmental surveillance of ESKAPE organisms and Escherichia coli in an equine hospital: Informing infection control

Equine Veterinary Journal, EarlyView.
Abstract Background Bacteria from the ESKAPE group (i.e., Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species) and Escherichia coli are frequently multidrug‐resistant and can be associated with healthcare‐associated infections, an increasing concern for veterinary ...
April Lawson, Gina Pinchbeck, Flavia Zendri, Cajsa Isgren, Jane Devaney, Fernando Malalana, Dorina Timofte   +6 more
wiley   +1 more source

Analysis of resistance genes of carbapenem-resistant Providencia rettgeri using whole genome sequencing

BMC Microbiology, 2023
Objective This study aimed to investigate the clinical infection characteristics and analyze the resistance gene carrying status of carbapenem-resistant Providencia rettgeri via whole genome sequencing (WGS). Methods Carbapenem-resistant P. rettgeri were
Mi Liu, Na Yi, Xinyi Wang, Rongrong Wang
doaj   +1 more source

Hydrogel‐Based Bioelectronics: From Therapy and Sensing to Neuromorphic Computation

FlexTech, EarlyView.
This review establishes a material–conduction–property–application framework connecting hydrogel chemistry and charge transport with therapy, sensing, closed‐loop feedback, and neuromorphic computation. ABSTRACT Bioelectronics establish bidirectional communication between living systems and electronic devices, providing an enabling platform for ...
Jianlong Hong, Jiaqi Lu, Yijun Hao, Ning Ren, Shuhan He, Haobo Qi, Jingfeng Xu, Chengkuo Lee   +7 more
wiley   +1 more source

Prevalence of carbapenem resistant isolates.

, 2018
Prevalence of carbapenem resistant isolates.
Mohamed T. Mansour (5698358), Noha A. Kamel (5698349), Mona R. El-Ansary (5698355), Wafaa N. El-tayeb (5698352), Khaled M. Aboshanab (3753061)   +4 more
core   +1 more source

Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia

iMeta, EarlyView.
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen, Xiaoling Wang, Xiang Liu, Kui Dong, Yanying Feng, Min Yuan, Shiyi Wang, Fangfang Fan, Yong Tian, Zhiming Kang, Xiushuai Du, Chaolu Hasi, Hong Lu, Wei Guan, Xu Chen, Mengyu Cheng, Wei Wei, Nan Guo, Zhiguo Liu, Xiaotong Qiu, Yiwei Shi, Kun Xiao, Yi Wang, Zhenjun Li   +23 more
wiley   +1 more source

Lactobacillus derived small RNAs protect against Klebsiella pneumoniae infection

iMeta, EarlyView.
This study reveals that plant‐derived natural products confer protection against carbapenem‐resistant Klebsiella pneumoniae (CRKP) infection via remodeling the gut microbiota, with Lactobacillus identified as the core beneficial genus. Mechanistically, Lactobacillus murinus (L.
Tingting Xu, Xiuying Tao, Dan Fang, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +5 more
wiley   +1 more source