Results 41 to 50 of about 849,115 (259)

Synergism of eravacycline combined with other antimicrobial agents against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii

Journal of Global Antimicrobial Resistance, 2022
: Objectives: This study aimed to investigate the synergistic activity of eravacycline combined with other antimicrobial agents against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii collected from China.
Yun Li, Lanqing Cui, Feng Xue, Qing Wang, Bo Zheng   +4 more
doaj   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Status of Antibiotic Susceptibility of Polymyxin B And Colistin in the Treatment of Carbapenem Resistant Gram Negative Bacterial Infections: An Observational Study

Journal of Nepal Medical Association
Introduction: The emergence and rapid spread of multidrug-resistant gram-negative bacteria is a global concern. Polymyxin B and Colistin have gained significance due to the scarcity of new antibiotics and the high morbidity and mortality associated with
Ashish Kumar Bhattarai, Khilasa Pokharel, Marina Vaidya Shrestha   +2 more
doaj   +1 more source

Carbapenem-resistant bacteria in the environment

Arhiv za higijenu rada i toksikologiju
Abstract Carbapenem-resistant bacteria (CRB) pose a significant threat to public health due to their resistance to last-resort antibiotics. Even though they are widely studied in clinical settings, much less is known about their presence in environmental compartments with multiple pathways contributing to their ...
Dadić, Blanka, Hrenović, Jasna, Ivanković, Tomislav   +2 more
openaire   +4 more sources

Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes [PDF]

Diagnostic Microbiology and Infectious Disease, 2013
The emergence of carbapenem resistance in Enterobacteriaceae is an important threat to global health. Reported outcomes of infections with carbapenem-resistant Enterobacteriaceae (CRE) are poor. Very few options remain for the treatment of these virulent organisms.
David, van Duin, Keith S, Kaye, Elizabeth A, Neuner, Robert A, Bonomo   +3 more
openaire   +2 more sources

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

IN VITRO EFFICACY OF CICLOPIROX AGAINST CARBAPENEM RESISTANT ENTEROBACTERIACEAE

Pakistan Armed Forces Medical Journal, 2021
Objective: To determine the in vitro efficacy of Ciclopirox against Carbapenem Resistant Enterobacteriaceae by determining its minimum inhibitory concentration by micro agar dilution method. Study Design: Quasi experimental study.
Maliha Ansari, Hassan Ikram, Nadia Saad, Aaminah Hanif, Aiza Sadia, Qazi Ikram Ullah   +5 more
doaj  

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Association between antibiotic consumption and the rate of carbapenem-resistant Gram-negative bacteria from China based on 153 tertiary hospitals data in 2014

Antimicrobial Resistance and Infection Control, 2018
Background This study aimed to investigate the relationship between the rate of carbapenem-resistant Gram-negative bacteria and antibiotic consumption intensity in 153 tertiary hospitals from China in 2014.
Ping Yang, Yunbo Chen, Saiping Jiang, Ping Shen, Xiaoyang Lu, Yonghong Xiao   +5 more
doaj   +1 more source