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Neurotoxicity of Carbapenem Antibacterials

Drug Safety, 1996
Similar to other beta-lactam antibacterials, carbapenems have a neurotoxic potential that seems to be higher than that of the penicillins and cephalosporins. Seizures have been reported in several large studies of patients treated with imipenem/cilastatin.
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Ertapenem: a new carbapenem

Expert Opinion on Investigational Drugs, 2001
Ertapenem is a new 1-beta-methyl carbapenem, stable to dehydropeptidase, which binds preferable to penicillin-binding proteins (PBP) 2 and 3. Ertapenem has a broad antibacterial spectrum with MIC90 values < 0.5 mg/l for penicillin-susceptible Streptococcus pneumoniae, Streptococcus pyogenes, methicillin-sensitive Staphylococcus aureus, Haemophilus ...
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Carbapenems for Surgical Prophylaxis?

New England Journal of Medicine, 2006
In this issue of the Journal, Itani and colleagues1 describe a study in which 1002 patients were randomly assigned to receive either ertapenem or cefotetan in a single dose before elective colorectal surgery. Many experienced surgeons and hospital epidemiologists will probably be surprised that the overall rate of failure in the modified intention-to ...
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Bacterial Resistance to Carbapenems

1995
The carbapenems have the broadest spectra of all beta-lactams but resistance still occurs, caused by target modification, impermeability or beta-lactamase production. Target modification or replacement is important in methicillin-resistant staphylococci, E. faecium and some pneumococci.
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Carbapenems

Seminars in Pediatric Infectious Diseases, 2001
Katherine M. Knapp, B.Keith English
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A Review of Carbapenem Resistance in Enterobacterales and Its Detection Techniques

Microorganisms, 2023
Evangelyn Alocilja   +1 more
exaly  

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