Results 191 to 200 of about 28,387 (241)
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Obstetrics and Gynecology Clinics of North America, 1989
Carbapenems and penems are a unique class of antibiotics. These agents have a broad spectrum of activity, with activity against aerobic and anaerobic bacteria, often including bacteria possessing multiple resistant factors.
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Carbapenems and penems are a unique class of antibiotics. These agents have a broad spectrum of activity, with activity against aerobic and anaerobic bacteria, often including bacteria possessing multiple resistant factors.
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Comparative Review of the Carbapenems
Drugs, 2007The carbapenems are beta-lactam antimicrobial agents with an exceptionally broad spectrum of activity. Older carbapenems, such as imipenem, were often susceptible to degradation by the enzyme dehydropeptidase-1 (DHP-1) located in renal tubules and required co-administration with a DHP-1 inhibitor such as cilastatin. Later additions to the class such as
George G, Zhanel +7 more
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Journal of Infection and Chemotherapy, 2018
The emergence and dissemination of antimicrobial resistance is a worldwide problem. Inappropriate antimicrobial use contributes to this resistance, and several metrics of drug usage have been used to monitor their consumption and rational use. We examined several existing drug metrics, and developed a new one, dose/duration-density (D/d2), for a the ...
Shinobu Hirayama +10 more
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The emergence and dissemination of antimicrobial resistance is a worldwide problem. Inappropriate antimicrobial use contributes to this resistance, and several metrics of drug usage have been used to monitor their consumption and rational use. We examined several existing drug metrics, and developed a new one, dose/duration-density (D/d2), for a the ...
Shinobu Hirayama +10 more
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Recent developments in carbapenems
Expert Opinion on Investigational Drugs, 2002Carbapenems are beta-lactam antibiotics characterised by the presence of a beta-lactam ring with a carbon instead of sulfone in the 4-position of the thyazolidinic moiety. The first carbapenem to be utilised in therapy was imipenem, the N-formimidoyl derivative of thienamycin.
Giovanni, Bonfiglio +2 more
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CEPHALOSPORINS, CARBAPENEMS, AND MONOBACTAMS
Infectious Disease Clinics of North America, 2000Nonpenicillin beta-lactams exhibit a variable spectrum of antimicrobial activity, have a wide range of clinical uses and a favorable safety profile. Cefepime's twice-daily dosage and increased activity against Enterobacteriaceae may offer some advantages over older cephalosporins.
L E, Asbel, M E, Levison
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Expert Opinion on Investigational Drugs, 2001
Ertapenem is a new 1-beta-methyl carbapenem, stable to dehydropeptidase, which binds preferable to penicillin-binding proteins (PBP) 2 and 3. Ertapenem has a broad antibacterial spectrum with MIC90 values < 0.5 mg/l for penicillin-susceptible Streptococcus pneumoniae, Streptococcus pyogenes, methicillin-sensitive Staphylococcus aureus, Haemophilus ...
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Ertapenem is a new 1-beta-methyl carbapenem, stable to dehydropeptidase, which binds preferable to penicillin-binding proteins (PBP) 2 and 3. Ertapenem has a broad antibacterial spectrum with MIC90 values < 0.5 mg/l for penicillin-susceptible Streptococcus pneumoniae, Streptococcus pyogenes, methicillin-sensitive Staphylococcus aureus, Haemophilus ...
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Neurotoxicity of Carbapenem Antibacterials
Drug Safety, 1996Similar to other beta-lactam antibacterials, carbapenems have a neurotoxic potential that seems to be higher than that of the penicillins and cephalosporins. Seizures have been reported in several large studies of patients treated with imipenem/cilastatin.
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Carbapenems for Surgical Prophylaxis?
New England Journal of Medicine, 2006In this issue of the Journal, Itani and colleagues1 describe a study in which 1002 patients were randomly assigned to receive either ertapenem or cefotetan in a single dose before elective colorectal surgery. Many experienced surgeons and hospital epidemiologists will probably be surprised that the overall rate of failure in the modified intention-to ...
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Bacterial Resistance to Carbapenems
1995The carbapenems have the broadest spectra of all beta-lactams but resistance still occurs, caused by target modification, impermeability or beta-lactamase production. Target modification or replacement is important in methicillin-resistant staphylococci, E. faecium and some pneumococci.
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Seminars in Pediatric Infectious Diseases, 2001
Katherine M. Knapp, B.Keith English
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Katherine M. Knapp, B.Keith English
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