Results 41 to 50 of about 17,864 (222)

Carbapenemases

, 2019
Carbapenems are usually regarded as the last treatment option for serious infections caused by Gram-negative and Gram-positive microorganisms. Although they are stable to hydrolysis by most β- lactamases, their usage as the last resort antbiotics was seriously compromised by the appearance of carbapenem-hydrolyzing enzymes called carbapenemases.
Bedenić, Branka, Sardelić, Sanda
openaire   +2 more sources

Detection and Characterization of Carbapenemase-Producing Escherichia coli and Klebsiella pneumoniae from Hospital Effluents of Ouagadougou, Burkina Faso

Antibiotics, 2023
Hospital wastewater is a recognized reservoir for resistant Gram-negative bacteria. This study aimed to screen for carbapenemase-producing Escherichia coli and Klebsiella pneumoniae and their resistance determinants in two hospital effluents of ...
Alix Bénédicte Kagambèga, René Dembélé, Léa Bientz, Fatima M’Zali, Laure Mayonnove, Alassane Halawen Mohamed, Hiliassa Coulibaly, Nicolas Barro, Véronique Dubois   +8 more
doaj   +1 more source

Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery [PDF]

, 2019
Serine and metallo-carbapenemases are a serious health concern due to their capability to hydrolyze nearly all β-lactam antibiotics. However, the molecular basis for their unique broad-spectrum substrate profile is poorly understood, particularly for ...
Orville A. Pemberton, Adam R. Renslo (114387), Xiujun Zhang (390551), Priyadarshini Jaishankar, Yu Chen, Nicholas J. Torelli (6589088), Afroza Akhtar (6589091), Orville A. Pemberton (6589094), Cody Johnson (679986), Priyadarshini Jaishankar (114359), Afroza Akhtar, Yu Chen (29959), Xiujun Zhang, Kyle DeFrees (1859197), Cody Johnson, Nicholas J. Torelli, Adam R. Renslo, Kyle DeFrees   +17 more
core   +1 more source

Carbapenemase-Producing Organisms: A Global Scourge [PDF]

Clinical Infectious Diseases, 2017
The dramatic increase in the prevalence and clinical impact of infections caused by bacteria producing carbapenemases is a global health concern. Carbapenemase production is especially problematic when encountered in members of the family Enterobacteriaceae.
Bonomo, Robert A, Burd, Eileen M, Conly, John, Limbago, Brandi M, Poirel, Laurent, Segre, Julie A, Westblade, Lars F   +6 more
openaire   +4 more sources

Structure-Function Relationships of Class D Carbapenemases [PDF]

, 2016
Class D carbapenemases, also known as Carbapenem-Hydrolyzing class D β-Lactamases (CHDLs) are of increasingly high clinical relevance, as they have been found in various important human pathogens, such as Acinetobacter baumannii and Klebsiella pneumoniae
MANGANI, STEFANO, Mangani, S., Docquier, Jean-Denis, DOCQUIER, JEAN DENIS   +3 more
core   +1 more source

First report of OXA-48-producing Klebsiella pneumoniae strains in Iran

GMS Hygiene and Infection Control, 2014
[english] Carbapenem-resistant are increasingly reported worldwide and cause therapeutic problem in health care facilities. In this study 28 imipenem-resistant were examined for expression of carbapenemases by phenotypic and genotypic methods. Modified
Azimi, Leila, Nordmann, Patrice, Lari, Abdolaziz Rastegar, Bonnin, Rémy A.   +3 more
doaj   +1 more source

Carbapenemase-Producing Enterobacteriaceae in Spain in 2012 [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT We report the epidemiological impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2012. Of the 237 carbapenemases detected, 163 were from the OXA-48 group, 60 were from VIM-1, 8 were from KPC-2, 5 were from IMP, and 1 was from NDM-1.
Oteo-Iglesias, Jesus, Saez, David, Bautista, Veronica, Fernandez-Romero, Sara, Hernández-Molina, Juan Manuel, Perez-Vazquez, Maria, Aracil, Belen, Campos, Jose   +7 more
openaire   +3 more sources

Antimicrobial Sensitivity Profile and Resistance Gene Research in Escherichia coli Isolated From Water and Fish From Lagoa da Conceição, Florianópolis, SC, Brazil

Food Safety and Health, EarlyView.
This paper highlights a concerning scenario of environmental contamination by multidrug‐resistant bacteria, underscoring the need for integrated surveillance and control strategies to address antimicrobial resistance in aquatic environments within the context of One Health.
Francisco Lucas de Amorim Nascimento, Luan Amaral Alexandre, Cynthia Farias Manassi, Alice Cristina da Silva, Luísa Aimée Schmitt Lobe, Gustavo Rocha, Mateus Rocha Ribas, Victor Wolleck, Gabriele Caroline Gottschalk de Abreu, Alessandra Valéria Vortmann, Sheila Mello da Silveira, Rodrigo Barcellos Hoff, Jussara Kasuko Palmeiro, Silvani Verruck   +13 more
wiley   +1 more source

A case–control study of infections caused by Klebsiella pneumoniae producing New Delhi metallo-beta-lactamase-1: Predictors and outcomes

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionInfections caused by antimicrobial-resistant bacteria are a significant cause of death worldwide, and carbapenemase-producing bacteria are the principal agents.
Eduardo Rodríguez-Noriega, Elvira Garza-González, Paola Bocanegra-Ibarias, Beatriz Alejandra Paz-Velarde, Sergio Esparza-Ahumada, Sergio Esparza-Ahumada, Esteban González-Díaz, Esteban González-Díaz, Héctor R. Pérez-Gómez, Rodrigo Escobedo-Sánchez, Gerardo León-Garnica, Gerardo León-Garnica, Rayo Morfín-Otero   +12 more
doaj   +1 more source

Interpretation of Key Updates in the 36th Edition of Clinical and Laboratory Standards Institute M100 Standard

iLABMED, EarlyView.
ABSTRACT The Clinical and Laboratory Standards Institute M100 document serves as a cornerstone standard for clinical microbiology laboratories in China. Maintaining the scientific rigor of its predecessors, the 36th edition incorporates updated epidemiological cutoff values, pharmacokinetic/pharmacodynamic data, and clinical efficacy evidence to revise
Kanghong Xu, Qi Wang, Hui Wang
wiley   +1 more source