Results 41 to 50 of about 24,596 (232)

First report of OXA-48-producing Klebsiella pneumoniae strains in Iran

GMS Hygiene and Infection Control, 2014
[english] Carbapenem-resistant are increasingly reported worldwide and cause therapeutic problem in health care facilities. In this study 28 imipenem-resistant were examined for expression of carbapenemases by phenotypic and genotypic methods. Modified
Azimi, Leila, Nordmann, Patrice, Lari, Abdolaziz Rastegar, Bonnin, Rémy A.   +3 more
doaj   +1 more source

Klebsiella pneumoniaeCarbapenemase, Canada

Emerging Infectious Diseases, 2009
To the Editor: Carbapenems are used to treat life-threatening infections caused by extremely drug-resistant gram-negative pathogens; these drugs represent the last line of defense in the antimicrobial drug armamentarium against serious or invasive infection (1). The rapid global spread of Klebsiella pneumoniae that produces K. pneumoniae carbapenemase (
Dylan R. Pillai, Roberto G. Melano, Prasad Rawte, Stephen Lo, Nathalie Tijet, Milan Fuksa, Nancy Roda, David J. Farrell, Sigmund Krajden   +8 more
openaire   +2 more sources

WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases [PDF]

, 2017
Background: Several diazabicyclooctanes (DBOs) are under development as inhibitors of Class A and C -lactamases. Inhibition of OXA (Class D) carbapenemases is variable, with those of Acinetobacter spp. remaining notably resistant. We describe a novel DBO,
Anna Vickers, Clinical and Laboratory Standards Institute, David M. Livermore, Neil Woodford, Shazad Mushtaq   +4 more
core   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Novel Rapid Test for Detecting Carbapenemase [PDF]

Emerging Infectious Diseases, 2020
We developed a carbapenemase test based on the ability of imipenem to inhibit noncarbapenemase β-lactamases. The test uses bacterial isolates with a fluorescent β-lactamase substrate, producing objective results with 100% sensitivity and specificity in 10 minutes. The assay is inexpensive and consists of only 1 mixing step.
Yanfang Feng, Akilan Palanisami, Jerrin Kuriakose, Michael Pigula, Shoaib Ashraf, Tayyaba Hasan   +5 more
openaire   +3 more sources

High levels of cyclic di-GMP in Klebsiella pneumoniae attenuate virulence in the lung [PDF]

, 2018
The bacterial second messenger bis-(3′-5′)-cyclic dimeric GMP (c-di-GMP) has been shown to influence the expression of virulence factors in certain pathogenic bacteria, but little is known about its activity in the increasingly antibiotic-resistant ...
Hunstad, David A, Rosen, David A, Twentyman, Joy   +2 more
core   +2 more sources

Machine Learning‐Augmented Loop‐Mediated Isothermal Amplification‐Enabled Point‐of‐Care for Mpox‐Specific Detection

Advanced Intelligent Systems, EarlyView.
A low‐cost, portable point‐of‐care platform for rapid Mpox detection using loop‐mediated isothermal amplification is reported. The device integrates fluorescence readout and mobile monitoring. A machine‐learning model analyzes temperature data and correlates thermal changes with DNA concentration, enabling sensitive and reliable molecular diagnosis in ...
Nazente Atceken, Ahmed Choukri Abdullah, Olgac Ozarslan, Ziya Yıldız, Savas Tasoglu   +4 more
wiley   +1 more source

Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014. [PDF]

, 2016
In 2014, a total of 2,976 Enterobacteriaceae isolates with decreased susceptibility to carbapenems were received at the French Associated National Reference Center for Antibiotic Resistance (NRC) and were characterised for their molecular resistance ...
Cuzon, G., Dortet, L., Nordmann, P., Ponties, V.   +3 more
core   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Carbapenemase-producingEnterobacteriaceae, U.S. Rivers

Emerging Infectious Diseases, 2005
Our study was initiated by previous isolation of 30 imipenem-resistant, gram-negative rods from 7 of 16 U.S. rivers sampled from 1999 to 2001. Imipenem hydrolysis was detected in 22 of those isolates identified as Enterobacter asburiae. Random amplified polymorphism DNA analysis showed that these E. asburiae isolates were genetically indistinguishable.
Cécile Aubron, Laurent Poirel, Ronald J Ash, Patrice Nordmann   +3 more
openaire   +3 more sources