Results 31 to 40 of about 15,899 (181)

Mobile Carbapenemase Genes in Pseudomonas aeruginosa [PDF]

Frontiers in Microbiology, 2021
Carbapenem-resistantPseudomonas aeruginosais one of the major concerns in clinical settings impelling a great challenge to antimicrobial therapy for patients with infections caused by the pathogen. While membrane permeability, together with derepression of the intrinsic beta-lactamase gene, is the global prevailing mechanism of carbapenem resistance ...
Eun-Jeong Yoon, Seok Hoon Jeong
openaire   +4 more sources

Carbapenemase-Producing Organisms: A Global Scourge [PDF]

Clinical Infectious Diseases, 2017
The dramatic increase in the prevalence and clinical impact of infections caused by bacteria producing carbapenemases is a global health concern. Carbapenemase production is especially problematic when encountered in members of the family Enterobacteriaceae.
Bonomo, Robert A, Burd, Eileen M, Conly, John, Limbago, Brandi M, Poirel, Laurent, Segre, Julie A, Westblade, Lars F   +6 more
openaire   +3 more sources

Carbapenemases

, 2019
Carbapenems are usually regarded as the last treatment option for serious infections caused by Gram-negative and Gram-positive microorganisms. Although they are stable to hydrolysis by most β- lactamases, their usage as the last resort antbiotics was seriously compromised by the appearance of carbapenem-hydrolyzing enzymes called carbapenemases.
Bedenić, Branka, Sardelić, Sanda
openaire   +2 more sources

Emerging carbapenemases in Gram-negative aerobes

, 2002
Carbapenemases may be defined as β-lactamases that significantly hydrolyze at least imipenem or/and meropenem. Carbapenemases involved in acquired resistance are of Ambler molecular classes A, B, and D.
L. Poirel, Nordmann, P., Poirel, L., P. Nordmann   +3 more
core   +1 more source

Carbapenemase-Producing Enterobacteriaceae in Spain in 2012 [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT We report the epidemiological impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2012. Of the 237 carbapenemases detected, 163 were from the OXA-48 group, 60 were from VIM-1, 8 were from KPC-2, 5 were from IMP, and 1 was from NDM-1.
Oteo-Iglesias, Jesus, Saez, David, Bautista, Veronica, Fernandez-Romero, Sara, Hernández-Molina, Juan Manuel, Perez-Vazquez, Maria, Aracil, Belen, Campos, Jose   +7 more
openaire   +3 more sources

Antimicrobial Sensitivity Profile and Resistance Gene Research in Escherichia coli Isolated From Water and Fish From Lagoa da Conceição, Florianópolis, SC, Brazil

Food Safety and Health, EarlyView.
This paper highlights a concerning scenario of environmental contamination by multidrug‐resistant bacteria, underscoring the need for integrated surveillance and control strategies to address antimicrobial resistance in aquatic environments within the context of One Health.
Francisco Lucas de Amorim Nascimento, Luan Amaral Alexandre, Cynthia Farias Manassi, Alice Cristina da Silva, Luísa Aimée Schmitt Lobe, Gustavo Rocha, Mateus Rocha Ribas, Victor Wolleck, Gabriele Caroline Gottschalk de Abreu, Alessandra Valéria Vortmann, Sheila Mello da Silveira, Rodrigo Barcellos Hoff, Jussara Kasuko Palmeiro, Silvani Verruck   +13 more
wiley   +1 more source

The epidemiology of carbapenemases in Latin America and the Caribbean

, 2020
Introduction: Enterobacteriaceae, Pseudomonas spp., and Acinetobacter spp. infections are major causes of morbidity and mortality, especially due to the emergence and spread of β-lactamases.
Reyes, Sergio, GUTIÉRREZ, SERGIO, Villegas, María Virginia, Escandón-Vargas, Kevin   +3 more
core   +1 more source

Genomic epidemiology and lineage‐specific risk stratification of tet(X4)‐mediated tigecycline resistance along the pork production chain: A One Health perspective

iMetaOmics, EarlyView.
Genome surveillance across a swine‐associated One Health continuum in China shows that slaughterhouses act as major enrichment nodes for tet(X4)‐mediated tigecycline resistance, driven by putative clonal transmission and stable plasmid backbones. Integrating global datasets enables lineage‐specific risk stratification, highlighting key control points ...
Qin Wang, Qiwu Yuan, Xuan Chen, Yujing Zhong, Ke Wu, Renqiao Wen, Luya Liu, Xiaoqin Wang, Cui Li, Hongning Wang, Changwei Lei   +10 more
wiley   +1 more source

An Xpert screen to identify carbapenemases

Indian Journal of Medical Microbiology, 2016
To prevent the spread of carbapenemases-producing Enterobacteriaceae (CPE) active surveillance, contact isolation and cohorting infected patients should be practiced. Rectal swabs for the Xpert MDRO-assay of 32 patients were included. 71.85% were positive for targets incorporated into the MDRO-assay; whereas 28% were phenotypically not CRE and Xpert ...
Mubin, Kazi, Chaitali, Nikam, Anjali, Shetty, Camilla, Rodrigues   +3 more
openaire   +2 more sources

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source