Results 11 to 20 of about 24,917 (198)

Rapidly spreading Enterobacterales with OXA-48-like carbapenemases

Journal of Clinical Microbiology
Enterobacterales (mostly Klebsiella pneumoniae, Escherichia coli) with OXA-48-like carbapenemases (e.g., OXA-48, -181, -232, -244) are undermining the global efficiency of carbapenem therapy. In the Middle East, North Africa, and some European countries,
Gisele Peirano, Johann D. D. Pitout
doaj   +3 more sources

Detection of rare carbapenemases in Enterobacterales—comparison of two colorimetric and three CIM-based carbapenemase assays

Microbiology Spectrum
Rapid and reliable detection of carbapenemase-producing Enterobacterales (CPE) is crucial for prompt treatment and infection control. Most assays target the primary four enzymes (KPC, OXA-48-like, VIM, and NDM), often missing less common variants (e.g ...
Lukas Schaffarczyk, Janina Noster, Yvonne Stelzer, Janko Sattler, Sören Gatermann, Axel Hamprecht   +5 more
doaj   +3 more sources

Phenotypic and Genotypic Features of Klebsiella pneumoniae Harboring Carbapenemases in Egypt: OXA-48-Like Carbapenemases as an Investigated Model

Antibiotics, 2020
This study aimed at the characterization of carbapenem-resistant Klebsiella pneumoniae isolates focusing on typing of the blaOXA-48-like genes. Additionally, the correlation between the resistance pattern and biofilm formation capacity of the carbapenem ...
Amani El Kholy, Abeer Abdulall, Mahmoud M Tawfick   +2 more
exaly   +3 more sources

Carbapenemases as factors of Resistance to Antibacterial Drugs [PDF]

Acta Biomedica Scientifica, 2021
Antibiotic drugs are used to treat and prevent bacterial infections around the world. The emergence and spread of  bacterial resistance to carbapenems is currently a real threat that determines the need for its timely detection and  suppression ...
A. V. Nevezhina
doaj   +2 more sources

Genetic Diversity, Biochemical Properties, and Detection Methods of Minor Carbapenemases in Enterobacterales

Frontiers in Medicine, 2021
Gram-negative bacteria, especially Enterobacterales, have emerged as major players in antimicrobial resistance worldwide. Resistance may affect all major classes of anti-gram-negative agents, becoming multidrug resistant or even pan-drug resistant ...
Rémy A. Bonnin, Rémy A. Bonnin, Rémy A. Bonnin, Agnès B. Jousset, Agnès B. Jousset, Agnès B. Jousset, Agnès B. Jousset, Cécile Emeraud, Cécile Emeraud, Cécile Emeraud, Cécile Emeraud, Saoussen Oueslati, Saoussen Oueslati, Laurent Dortet, Laurent Dortet, Laurent Dortet, Laurent Dortet, Thierry Naas, Thierry Naas, Thierry Naas, Thierry Naas   +20 more
doaj   +2 more sources

Molecular diversity of extended-spectrum β-lactamases and carbapenemases, and antimicrobial resistance

Journal of Intensive Care, 2020
Along with the recent spread of multidrug-resistant bacteria, outbreaks of extended-spectrum β-lactamase (ESBL) and carbapenemase-producing bacteria present a serious challenge to clinicians.
Teiji Sawa, Kunihiko Kooguchi, Kiyoshi Moriyama   +2 more
doaj   +2 more sources

The Global Ascendency of OXA-48-Type Carbapenemases

Clinical Microbiology Reviews, 2019
Surveillance studies have shown that OXA-48-like carbapenemases are the most common carbapenemases in Enterobacterales in certain regions of the world and are being introduced on a regular basis into regions of nonendemicity, where they are responsible ...
Yasufumi Matsumura, Marleen Kock, Johann Pitout   +2 more
exaly   +2 more sources

The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

Antibiotics, 2020
Carbapenemases are β-lactamases belonging to different Ambler classes (A, B, D) and can be encoded by both chromosomal and plasmid-mediated genes.
Dalal Hammoudi Halat, Carole Ayoub Moubareck   +1 more
exaly   +2 more sources

The emerging NDM carbapenemases

Trends in Microbiology, 2011
Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian
Nordmann, Patrice, Poirel, Laurent, Walsh, Timothy R, Livermore, David M   +3 more
openaire   +6 more sources

Emergence and Spread of Enterobacterales with Multiple Carbapenemases after COVID-19 Pandemic

Pathogens, 2023
Resistance to carbapenems in Enterobacterales has become a matter of the highest concern in the last decade. Recently, Enterobacterales harboring multiple carbapenemases were detected in three hospital centers in Croatia and in the outpatient setting ...
Dijana Varda Brkic, Branka Bedenić, Andrea Grisold   +2 more
exaly   +2 more sources