Results 11 to 20 of about 15,899 (181)
The emerging NDM carbapenemases
Trends in Microbiology, 2011 Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian
Nordmann, Patrice +3 more
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To Be or Not to Be an OXA-48 Carbapenemase [PDF]
Microorganisms, 2022 Since the first description of OXA-48, more than forty variants have been recovered from Enterobacterales isolates. Whereas some OXA-48-related enzymes have been reported as conferring similar resistance patterns, namely, the hydrolysis of carbapenems and penicillins with very weak or almost no activity against expanded-spectrum cephalosporins, some ...
Laura Dabos +5 more
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Azetidinimines as carbapenemases inhibitors
, 2017 The present application relates to novel azetidinimine of formula (I). Wherein R1-R6 are as defined in claim 1. The azetidinimine of the invention are useful as antibiotics and as inhibitors of a carbapenemases. The present invention thus further relates totheir use in antibiotic therapies and their methods of synthesis.
Dodd, Robert +4 more
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Journal of Antimicrobial Chemotherapy, 2007 Carbapenems, such as imipenem and meropenem, are most often used to treat infections caused by enterobacteria that produce extended-spectrum beta-lactamases, and the emergence of enzymes capable of inactivating carbapenems would therefore limit the options for treatment.
Walther-Rasmussen, J., Høiby, N.
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Carbapenemase-Producing Enterobacteriaceae [PDF]
Seminars in Respiratory and Critical Care Medicine, 2015 Carbapenemase-producing Enterobacteriaceae (CPE) were almost nonexistent up to the 1990s, but are today encountered routinely in hospitals and other healthcare facilities in many countries including the United States. KPC-producing Klebsiella pneumoniae was the first to emerge and spread globally and is endemic in the United States, Israel, Greece, and
Doi, Yohei, Paterson, David L.
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Journal of Antimicrobial Chemotherapy, 2006 In recent years, the number of class D beta-lactamases with carbapenem-hydrolysing properties has increased substantially. Based on amino acid sequence identities, these class D or OXA-type carbapenemases are divided into eight distantly related groups, and they are only remotely related to other class D beta-lactamases.
Walther-Rasmussen, J., Høiby, Niels
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Carbapenemase-producing Klebsiella pneumoniae [PDF]
F1000Prime Reports, 2014 The continuing emergence of infections due to multidrug resistant bacteria is a serious public health problem. Klebsiella pneumoniae, which commonly acquires resistance encoded on mobile genetic elements, including ones that encode carbapenemases, is a prime example. K. pneumoniae carrying such genetic material, including both blaKPC and genes encoding
Robilotti, Elizabeth, Deresinski, Stan
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Rapid detection of carbapenemases and ESKAPEEc bacteria [PDF]
Archives of the Balkan Medical Union, 2021 Introduction. Carbapenems have been the ultimate antibiotics for the treatment of infections caused by multidrug-resistant bacteria. However, recently, carbapenems-resistant bacteria have emerged significantly. The objective of the study was the identification of ESKAPEEc bacteria and rapid detection of carbapenemase production.
Aydoğan, Okan +1 more
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Carbapenemases as factors of Resistance to Antibacterial Drugs
, 2021 Antibiotic drugs are used to treat and prevent bacterial infections around the world. The emergence and spread of bacterial resistance to carbapenems is currently a real threat that determines the need for its timely detection and suppression ...
A. V. Nevezhina
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Carbapenemases: the Versatile β-Lactamases [PDF]
Clinical Microbiology Reviews, 2007 SUMMARYCarbapenemases are β-lactamases with versatile hydrolytic capacities. They have the ability to hydrolyze penicillins, cephalosporins, monobactams, and carbapenems. Bacteria producing these β-lactamases may cause serious infections in which the carbapenemase activity renders many β-lactams ineffective.
Anne Marie, Queenan, Karen, Bush
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