Results 51 to 60 of about 20,063 (216)

Carbapenemase-Producing Organisms: A Global Scourge [PDF]

Clinical Infectious Diseases, 2017
The dramatic increase in the prevalence and clinical impact of infections caused by bacteria producing carbapenemases is a global health concern. Carbapenemase production is especially problematic when encountered in members of the family Enterobacteriaceae.
Bonomo, Robert A, Burd, Eileen M, Conly, John, Limbago, Brandi M, Poirel, Laurent, Segre, Julie A, Westblade, Lars F   +6 more
openaire   +4 more sources

Metagenomic and culture‐based insights into host and plasmid contexts of high‐risk ARGs in poultry farm environments

iMetaOmics, EarlyView.
Shotgun metagenomics and culture‐based isolate genomics revealed position‐associated high‐risk antibiotic resistance genes (ARGs) signals across poultry manure piles and surrounding soils. Culture‐confirmed Enterobacteriaceae and IncHI2A‐related blaNDM‐5 plasmid backgrounds further highlight priority host‐ARG‐plasmid contexts for farm antimicrobial ...
Yaling Wang, Lianwei Ye, Linan He, Zhenlong Wu, Yiwen Yang, Sheng Chen   +5 more
wiley   +1 more source

Antimicrobial Resistance: Carbapenemases-producing bacteria in livestock

, 2016
Carbapenems are antibiotics authorised for the treatment of humans and categorised by the World Health Organisation as critically important antimicrobials. Antibiotics of this kind should only be administered when there are strict indications, i.e.
German Federal Institute for Risk Assessment (BfR)
core   +1 more source

A case–control study of infections caused by Klebsiella pneumoniae producing New Delhi metallo-beta-lactamase-1: Predictors and outcomes

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionInfections caused by antimicrobial-resistant bacteria are a significant cause of death worldwide, and carbapenemase-producing bacteria are the principal agents.
Eduardo Rodríguez-Noriega, Elvira Garza-González, Paola Bocanegra-Ibarias, Beatriz Alejandra Paz-Velarde, Sergio Esparza-Ahumada, Sergio Esparza-Ahumada, Esteban González-Díaz, Esteban González-Díaz, Héctor R. Pérez-Gómez, Rodrigo Escobedo-Sánchez, Gerardo León-Garnica, Gerardo León-Garnica, Rayo Morfín-Otero   +12 more
doaj   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery

, 2019
Serine and metallo-carbapenemases are a serious health concern due to their capability to hydrolyze nearly all β-lactam antibiotics. However, the molecular basis for their unique broad-spectrum substrate profile is poorly understood, particularly for ...
Orville A. Pemberton, Adam R. Renslo (114387), Xiujun Zhang (390551), Priyadarshini Jaishankar, Yu Chen, Nicholas J. Torelli (6589088), Afroza Akhtar (6589091), Orville A. Pemberton (6589094), Cody Johnson (679986), Priyadarshini Jaishankar (114359), Afroza Akhtar, Yu Chen (29959), Xiujun Zhang, Kyle DeFrees (1859197), Cody Johnson, Nicholas J. Torelli, Adam R. Renslo, Kyle DeFrees   +17 more
core   +1 more source

The epidemiology of carbapenemases in Latin America and the Caribbean

, 2020
Introduction: Enterobacteriaceae, Pseudomonas spp., and Acinetobacter spp. infections are major causes of morbidity and mortality, especially due to the emergence and spread of β-lactamases.
Reyes, Sergio, GUTIÉRREZ, SERGIO, Villegas, María Virginia, Escandón-Vargas, Kevin   +3 more
core   +1 more source

Carbapenemase-Producing Enterobacteriaceae in Spain in 2012 [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT We report the epidemiological impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2012. Of the 237 carbapenemases detected, 163 were from the OXA-48 group, 60 were from VIM-1, 8 were from KPC-2, 5 were from IMP, and 1 was from NDM-1.
Oteo-Iglesias, Jesus, Saez, David, Bautista, Veronica, Fernandez-Romero, Sara, Hernández-Molina, Juan Manuel, Perez-Vazquez, Maria, Aracil, Belen, Campos, Jose   +7 more
openaire   +3 more sources

Resistance and virulence features of hypermucoviscous Klebsiella pneumoniae from bloodstream infections: Results of a nationwide Italian surveillance study

Frontiers in Microbiology, 2022
Among Enterobacterales, Klebsiella pneumoniae (Kp) is one of the major opportunistic pathogens causing hospital-acquired infections. The most problematic phenomenon linked to Kp is related to the dissemination of multi-drug resistant (MDR) clones ...
Fabio Arena, Fabio Arena, Fabio Arena, Giulia Menchinelli, Vincenzo Di Pilato, Riccardo Torelli, Alberto Antonelli, Alberto Antonelli, Lucia Henrici De Angelis, Marco Coppi, Marco Coppi, Maurizio Sanguinetti, Maurizio Sanguinetti, Gian Maria Rossolini, Gian Maria Rossolini, Gian Maria Rossolini   +15 more
doaj   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

mLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei, Jiangqing Huang, Hailing Fang, Xinyu Wang, Gang Zhang, Chao Wang, Yuqin Song, Jie Feng   +7 more
wiley   +1 more source