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Among the many different structurally distinct classes of beta-lactams, the carbapenem class is regarded as that which is most potent and which has the widest spectrum of antimicrobial activity. Rapidly bactericidal, and demonstrating time-dependent killing, carbapenemes have a spectrum of antimicrobial activity that includes Gram-positive and Gram ...
Shah, P.M.
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New developments in carbapenems [PDF]
Antibiotic resistance among Gram-negative pathogens in hospitals is a growing threat to patients and is driving the increased use of carbapenems. Carbapenems are potent members of the beta-lactam family of antibiotics, with a history of safety and efficacy for serious infections that exceeds 20 years. Original and review articles were identified from a
Kattan, J.N. +2 more
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Carbapenem Resistance: A Review [PDF]
Carbapenem resistance is a major and an on-going public health problem globally. It occurs mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, and may be intrinsic or mediated by ...
Francis S. Codjoe, Eric S. Donkor
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Medication errors associated with carbapenems [PDF]
Purpose. The purpose of this study was to discover the prevalence and types of medication errors associated with the use of carbapenems. Materials and methods.
A. V. Kuz’mina +3 more
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Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae. [PDF]
OBJECTIVES: To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae. METHODS: MICs were determined using the broth microdilution method.
Hu, Y, Coates, A
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Long-term carbapenems antimicrobial stewardship program [PDF]
: Objective. To evaluate clinical and antibiotic resistance impact of carbapenems stewardship programs. Methods: descriptive study, pre-post-intervention, between January 2012 and December 2019; 350-bed teaching hospital. Prospective audit and feedback
Álvarez Díaz, Hortensia +5 more
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JMM Profile: Carbapenems: a broad-spectrum antibiotic [PDF]
Carbapenems are potent members of the β-lactam family that inhibit bacterial cell-wall biosynthesis inhibitors . They are highly effective against Gram-negative and Gram-positive drug-resistant infections .
Armstrong, Tom +2 more
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Archive of carbapenems containing sub-folders named after each compound and its net charge. Every compound's folder contains a total of 20 files distributed into three sub-directories reporting QM (QM/), FF (FF/), and MD (MD ...
Giuliano Malloci (2060875) +5 more
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Monooxygenases and Antibiotic Resistance: A Focus on Carbapenems [PDF]
Carbapenems are a group of broad-spectrum beta-lactam antibiotics that in many cases are the last effective defense against infections caused by multidrug-resistant bacteria, such as some strains of Klebsiella pneumoniae, Escherichia coli, Pseudomonas ...
Loqui, Davide +5 more
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In clinical settings, rapid and accurate diagnosis of antibiotic resistance is essential for the efficient treatment of bacterial infections. Conventional methods for antibiotic resistance testing are time consuming, while molecular methods such as PCR ...
Wei Liu +9 more
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