Results 41 to 50 of about 52,330 (263)

Long-Term Clinical and Ecological Impact of an Antimicrobial Stewardship Program on the Incidence of Carbapenem-Resistant Klebsiella pneumoniae Infections in a High-Endemic Hospital

Antibiotics
Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) is currently a serious global concern. Antimicrobial stewardship programs (ASPs) are one of the key strategies to overcome this resistance.
Teresa López-Viñau, Montserrat Muñoz-Rosa, Lidia Mª Ruiz-Lara, Lucrecia García-Martínez, Isabel Machuca, Irene Gracia-Ahufinger, Rafael Ruiz Montero, Juan José Castón, Ángela Cano, Elisa Ruiz-Arabi, José Ramón del Prado, Inmaculada Salcedo, Luis Martínez-Martínez, Julián Torre-Cisneros   +13 more
doaj   +1 more source

Synergistic Inhibition of MRSA by Chenodeoxycholic Acid and Carbapenem Antibiotics

Antibiotics, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) has posed a severe global health threat. In this study, we screened an antibiotic and non-antibiotic combination that provides a viable strategy to solve this issue by broadening the antimicrobial ...
Kaiyu Cui, Weifeng Yang, Shuang Liu, Dongying Li, Lu Li, Xing Ren, Yanan Sun, Gaiying He, Shuhua Ma, Jidan Zhang, Qing Wei, Yi Wang   +11 more
doaj   +1 more source

Resistance to carbapenems: mechanisms and detection methods [PDF]

, 2017
In the last two decades, carbapenems have been implemented for the treatment of infections due to last-generation cephalosporin-resistant Gram-negative infections.
Endimiani, Andrea
core   +1 more source

A Catalytic Asymmetric Route to Carbapenems

, 2016
Efficient syntheses of N-acetyl thienamycin and epithienamycin A in their readily deprotected form are reported where three contiguous stereocenters are established in a single catalytic asymmetric azetidinone-forming reaction.
Craig A. Townsend (1319868), Micah J. Bodner (1882933), Ryan M. Phelan (1617682)   +2 more
core   +1 more source

Interaction between valproic acid and carbapenems: Case series and literature review [PDF]

, 2012
Several case reports and retrospective studies have indicated that carbapenems decrease the serum concentration of valproic acid (VPA), thus decreasing its therapeutic activity.
Sun, Yi-Hsuan, Wu, Ta-Wei, Lee, Chih-Hsin, Wu, An-Jan, Lee, Ming-Chia   +4 more
core   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Breaking Through Resistance: Carbapenem-Resistant Nocardia?!—A Case Report

Medicina
Nocardia is an emerging bacterial disease that often affects patients with compromised immune systems. As the number of patients undergoing solid organ transplants continues to rise, and as more cancer survivors are treated with long-term immune ...
Vlad-Sabin Ivan, Paul-Gabriel Ciubotaru, Liviu Cirin, Florin Giru, Dan Costachescu, Daniel-Florin Lighezan, Roxana Buzas   +6 more
doaj   +1 more source

Carbapenem-Nonsusceptible Acinetobacter baumannii, 8 US Metropolitan Areas, 2012–2015

Emerging Infectious Diseases, 2018
In healthcare settings, Acinetobacter spp. bacteria commonly demonstrate antimicrobial resistance, making them a major treatment challenge. Nearly half of Acinetobacter organisms from clinical cultures in the United States are nonsusceptible to ...
Sandra N. Bulens, Sarah H. Yi, Maroya S. Walters, Jesse T. Jacob, Chris Bower, Jessica Reno, Lucy Wilson, Elisabeth Vaeth, Wendy Bamberg, Sarah J. Janelle, Ruth Lynfield, Paula Snippes Vagnone, Kristin Shaw, Marion Kainer, Daniel Muleta, Jacqueline Mounsey, Ghinwa Dumyati, Cathleen Concannon, Zintars Beldavs, P. Maureen Cassidy, Erin C. Phipps, Nicole Kenslow, Emily B. Hancock, Alexander J. Kallen   +23 more
doaj   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

Carbapenem-Resistant Gram-Negative Bacterial Infections at a Tertiary Health Care Center in Nepal: An Observational Study

Journal of Nepal Medical Association
Introduction: Carbapenems are last-resort antibiotics and are considered the drugs of choice for infections caused by multi-drug-resistant bacteria. During the last several years, there has been an alarming global increase in the detection and spread of
Dimpi Konwar, Navin Kumar Chaudhary, Poonam Yadav   +2 more
doaj   +1 more source