Results 61 to 70 of about 53,901 (244)

Structural compatibility between β‐lactams and substrate binding pockets of IMP‐1 and NDM‐1 determines the substrate spectrum

open access: yesBulletin of the Korean Chemical Society, EarlyView.
Chemical structures of three β‐lactam classes and the substrate‐binding pockets (SBPs) of B1 metallo‐β‐lactamases (MBLs) were compared. Structural compatibility between β‐lactams and MBL SBPs correlates with enzymatic activity, providing insights into the substrate spectrum of MBLs and β‐lactam resistance.
Kiwoong Kwak   +8 more
wiley   +1 more source

The Risk Factors of Carbapenem-Resistant Klebsiella pneumoniae Infection: A Single-Center Chinese Retrospective Study

open access: yesInfection and Drug Resistance, 2022
Lei Wang, Xiao-Dong Yuan, Ting Pang, Shu-Hong Duan Department of Infectious Diseases, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of ChinaCorrespondence: Shu-Hong Duan, Department of Infectious Diseases ...
Wang L, Yuan XD, Pang T, Duan SH
doaj  

Thirteen years of environmental surveillance of ESKAPE organisms and Escherichia coli in an equine hospital: Informing infection control

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Bacteria from the ESKAPE group (i.e., Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species) and Escherichia coli are frequently multidrug‐resistant and can be associated with healthcare‐associated infections, an increasing concern for veterinary ...
April Lawson   +6 more
wiley   +1 more source

Resistance to carbapenems: mechanisms and detection methods [PDF]

open access: yes, 2017
In the last two decades, carbapenems have been implemented for the treatment of infections due to last-generation cephalosporin-resistant Gram-negative infections.
Endimiani, Andrea
core   +1 more source

Molecular Characterization of Klebsiella pneumoniae Clinical Isolates with Elevated Resistance to Carbapenems

open access: yes, 2017
Background:Emergence of carbapenems-resistantK. pneumoniaerepresents a serious challenge for antimicrobial therapy.Objective:The aim of this research is to determine different mechanisms mediating the emergence ofK.
Mona Shaaban, Rasha Barwa
core   +1 more source

Modulation of the Specificity of Carbapenems and Diazabicyclooctanes for Selective Activity against Mycobacterium tuberculosis

open access: yes, 2022
Treatment of multidrug-resistant tuberculosis with combinations of carbapenems and β-lactamase inhibitors carries risks for dysbiosis and for the development of resistances in the intestinal microbiota. Using Escherichia coli
Michel Arthur   +21 more
core   +1 more source

Phenotypic detection of Metallo- and AmpC β-lactamases producing strains of P. aeruginosa in the state of Himachal Pradesh (India) [PDF]

open access: yesAl Ameen Journal of Medical Sciences, 2015
Background: A prospective study was undertaken to detect metallo-β-lactamases (MBLs) and AmpC β-lactamases in Pseudomonas aeruginosa isolates recovered from patients at Indira Gandhi Medical College, Shimla (H.P).
Naveen Minhas, Prakash Chand Sharma
doaj  

Hydrogel‐Based Bioelectronics: From Therapy and Sensing to Neuromorphic Computation

open access: yesFlexTech, EarlyView.
This review establishes a material–conduction–property–application framework connecting hydrogel chemistry and charge transport with therapy, sensing, closed‐loop feedback, and neuromorphic computation. ABSTRACT Bioelectronics establish bidirectional communication between living systems and electronic devices, providing an enabling platform for ...
Jianlong Hong   +7 more
wiley   +1 more source

Piperacillin-tazobactam as alternative to carbapenems for ICU patients

open access: yes, 2017
Several studies suggest that alternatives to carbapenems, and particulary beta-lactam/beta-lactamase inhibitor combinations, can be used for therapy of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE)-related infections in non-ICU ...
Zahar, Jean-Ralph   +9 more
core   +1 more source

Carbapenem-sparing beta-lactam/beta-lactamase inhibitors versus carbapenems for bloodstream infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae: a systematic review and meta-analysis

open access: yes, 2023
Objectives: Bloodstream infections (BSIs) caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) have become a worldwide public health threat, and beta-lactam/beta-lactamase inhibitor combinations (BLBLIs) are considered as one
Qinyan Xiao   +6 more
core   +1 more source

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