Results 71 to 80 of about 52,330 (263)

Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study

Brazilian Journal of Infectious Diseases
In vitro activity of doripenem and comparator antimicrobial agents was evaluated against Gram-negative bacilli recently isolated from Brazilian private hospitals that were enrolled in the INVITA-A-DORI Brazilian Study. A total of 805 unique Gram-negative
Ana Cristina Gales, Heber D Azevedo, Rosângela Ferraz Cereda, Raquel Girardello, Danilo Elias Xavier   +4 more
doaj   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

Small, EarlyView.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen, Matteo Tollemeto, Alexander B. Cook, Claus Sternberg, Yudong Li, Claus Moser, Lars Jelsbak, Jan C. M. Van Hest, Anja Boisen, Line Hagner Nielsen   +9 more
wiley   +1 more source

Isolation of carbapenem‐resistant Pseudomonas aeruginosa and other Gram‐negative ESKAPE organisms from samples of raw‐meat diets for dogs in the UK

Veterinary Record, EarlyView.
Abstract Background Gram‐negative ESKAPE organisms are an emerging threat in veterinary medicine that also have zoonotic potential. However, little is known about the prevalence and risks of these organisms in pet food. We present the incidental finding of gram‐negative ESKAPE organisms within samples of raw meat diets for dogs in the United Kingdom ...
Genever Morgan, Nicola Williams, Jenny Llewelyn, Sam Haldenby, Gina Pinchbeck, Dorina Timofte   +5 more
wiley   +1 more source

Investigation on the Use and Preauthorization of Carbapenems at A National Hospital in Vietnam: A Cross‐Sectional Study

Pharmacology Research & Perspectives
Carbapenems, known for their broad‐spectrum activity and used as last‐line treatment for severe drug‐resistant infections, are encountering increasing resistance.
Han Ngoc Bao Pham, Nhi Truc Y. Nguyen, Nhu Quynh Tran, An Thi Thanh Nguyen, Cam Thi Le Pham, Nhan Thi Thanh Dang, Hien Thi Thu Pham, Thong Duy Vo, Mai Thi Phuong Tran, Quynh Thi Huong Bui   +9 more
doaj   +1 more source

Antibody-Mediated Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils

mBio, 2018
Carbapenem-resistant Klebsiella pneumoniae is a problem worldwide. A carbapenem-resistant K. pneumoniae lineage classified as multilocus sequence type 258 (ST258) is prominent in the health care setting in many regions of the world, including the United ...
Scott D. Kobayashi, Adeline R. Porter, Brett Freedman, Ruchi Pandey, Liang Chen, Barry N. Kreiswirth, Frank R. DeLeo   +6 more
doaj   +1 more source

Activity of carbapenems and tigecycline against ESBL-producing Escherichia coli and Klebsiella spp.

, 2018
The indiscriminate use of carbapenems in the fight against multidrug resistant Gram-negative bacteria leads to the emergence of resistance to these antimicrobial agents.
Fernando Ferrugem, Renan V. Schmidt, Daniel Prá, Jorge André Horta, Renan V. Schmidt (5110937), Caio Fernando de Oliveira (5110925), Fernando Ferrugem (5110928), Daniel Prá (5110931), Jorge André Horta (5110934), Caio Fernando de Oliveira   +9 more
core   +1 more source

Evolutionary and Epidemiological Characterization of Multidrug‐Resistant Escherichia coli Isolated From Pangolins in China

Integrative Zoology, EarlyView.
ABSTRACT Malayan pangolin populations have fallen to a critically endangered level, and illegal trafficking of wild pangolins is a global problem. Little is known about antimicrobial‐resistant bacteria (MDRB) harbored by pangolins, although pangolins are frequently consumed as food or used in traditional medicine. In this study, we report for the first
Yawen Wang, Xue Wang, Jianan Zhao, Jun Zeng, Shijia Hu, Fang Ji, Guoying Dong, Hongxuan He, Chengmin Wang   +8 more
wiley   +1 more source

Prevalence of carbapenem resistance genes in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii from meat samples [PDF]

Medical Laboratory Journal
Background: Infections caused by bacteria transmitted from food, including carbapenem-resistant Enterobacteriaceae, Pseudomonas aeruginosa (P. aeruginosa), and Acinetobacter baumannii (A.
Maryam Rezaeian, Laleh Hoveida
doaj  

Horizontally Acquired Quorum-Sensing Regulators Recruited by the PhoP Regulatory Network Expand the Host Adaptation Repertoire in the Phytopathogen Pectobacterium brasiliense

mSystems, 2020
In this study, we examine the impact of transcriptional network rearrangements driven by horizontal gene acquisition in PhoP and SlyA regulons using as a case study a phytopathosystem comprised of potato tubers and the soft-rot pathogen Pectobacterium ...
Daniel Bellieny-Rabelo, Ntombikayise Precious Nkomo, Divine Yufetar Shyntum, Lucy Novungayo Moleleki   +3 more
doaj   +1 more source